Basic Information:

  VIRBase ID:  

HHID00007291

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19b-1-5p:  MIMAT0004491          CDK4:  NM_000075     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19b-1-5p	CDK4
miRBase Accession/Entrez ID	MIMAT0004491	1019
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CMM3//PSK-J3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19b-1-5p	rs1330845252 chr13:91351221    G/A rs771220050 chr13:91351229    C/T rs1259633726 chr13:91351212    T/G rs1279688822 chr13:91351213    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDK4	chr12:58144306(-) A-I      intronic chr12:58144164(-) A-I      intronic chr12:58142707(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDK4	chr12:58142491(-) G-A intron -    22484847 chr12:58143571(-) T-C intron -    22484847 chr12:58143593(-) T-C intron -    22484847 chr12:58144164(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDK4	chr12:58141854-58141855(-) m6A 3'UTR       27773535 chr12:58142034-58142035(-) m6A 3'UTR       24284625 chr12:58142039-58142040(-) m6A 3'UTR       24284625 chr12:58142255-58142256(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr12:58142987-58142988(-) Gm 3'UTR//CDS//exon       - chr12:58145029-58145030(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145039-58145040(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145047-58145048(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145053-58145054(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145096-58145097(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145194-58145195(-) m6A exon//intron       27773535 chr12:58145236-58145237(-) m6A exon//intron       27773535 chr12:58145445-58145446(-) m6A 5'UTR//CDS//exon//intron       22575960 chr12:58146013-58146014(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22575960 chr12:58146042-58146043(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19b-1-5p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	CDK4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19b-1-5p
Interactor2: CDK4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).