Basic Information:

  VIRBase ID:  

HHID00007213

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          CEP85L:  NM_001178035     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	CEP85L
miRBase Accession/Entrez ID	MIMAT0004490	387119
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	bA57K17.2//C6orf204//LIS10//NY-BR-15

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEP85L	chr6:118898517(-) A-I      intronic chr6:118993074(-) A-I      intronic chr6:118993062(-) A-I      intronic chr6:118993056(-) A-I      intronic chr6:118993014(-) A-I      intronic chr6:118848345(-) A-I      intronic chr6:118848343(-) A-I      intronic chr6:118848337(-) A-I      intronic chr6:118848270(-) A-I      intronic chr6:118848263(-) A-I      intronic chr6:118848217(-) A-I      intronic chr6:118836262(-) A-I      intronic chr6:118836229(-) A-I      intronic chr6:118835684(-) A-I      intronic chr6:118835656(-) A-I      intronic chr6:118993067(-) A-I      intronic chr6:118835655(-) A-I      intronic chr6:118835612(-) A-I      intronic chr6:118835605(-) A-I      intronic chr6:118835471(-) A-I      intronic chr6:118835437(-) A-I      intronic chr6:118817656(-) A-I      intronic chr6:119025865(-) A-I      intronic chr6:119028370(-) A-I      intronic chr6:119020371(-) A-I      intronic chr6:119028630(-) A-I      intronic chr6:119028632(-) A-I      intronic chr6:118969251(-) A-I      intronic chr6:118978700(-) A-I      intronic chr6:119020556(-) A-I      intronic chr6:119017376(-) A-I      intronic chr6:119020381(-) A-I      intronic chr6:118995651(-) A-I      intronic chr6:118993847(-) A-I      intronic chr6:118993781(-) A-I      intronic chr6:118993760(-) A-I      intronic chr6:118993756(-) A-I      intronic chr6:118993737(-) A-I      intronic chr6:118993360(-) A-I      intronic chr6:118848410(-) A-I      intronic chr6:118993037(-) A-I      intronic chr6:118992938(-) A-I      intronic chr6:118992935(-) A-I      intronic chr6:118992921(-) A-I      intronic chr6:118992866(-) A-I      intronic chr6:118986717(-) A-I      intronic chr6:118986710(-) A-I      intronic chr6:118986698(-) A-I      intronic chr6:118986660(-) A-I      intronic chr6:119017348(-) A-I      intronic chr6:118986610(-) A-I      intronic chr6:118983630(-) A-I      intronic chr6:118983527(-) A-I      intronic chr6:118982253(-) A-I      intronic chr6:118982111(-) A-I      intronic chr6:118982091(-) A-I      intronic chr6:118978771(-) A-I      intronic chr6:118978598(-) A-I      intronic chr6:118968820(-) A-I      intronic chr6:118968800(-) A-I      intronic chr6:118968798(-) A-I      intronic chr6:118968797(-) A-I      intronic chr6:118968718(-) A-I      intronic chr6:118958617(-) A-I      intronic chr6:118958616(-) A-I      intronic chr6:118953424(-) A-I      intronic chr6:118953389(-) A-I      intronic chr6:118953386(-) A-I      intronic chr6:118953291(-) A-I      intronic chr6:118953276(-) A-I      intronic chr6:118929601(-) A-I      intronic chr6:118929546(-) A-I      intronic chr6:118900354(-) A-I      intronic chr6:118900338(-) A-I      intronic chr6:118995654(-) A-I      intronic chr6:119005672(-) A-I      intronic chr6:119017322(-) A-I      intronic chr6:119020954(-) A-I      intronic chr6:119020969(-) A-I      intronic chr6:119020973(-) A-I      intronic chr6:119020986(-) A-I      intronic chr6:119020996(-) A-I      intronic chr6:119021125(-) A-I      intronic chr6:119023975(-) A-I      intronic chr6:119023992(-) A-I      intronic chr6:119024001(-) A-I      intronic chr6:119025772(-) A-I      intronic chr6:118900323(-) A-I      intronic chr6:118900320(-) A-I      intronic chr6:119025828(-) A-I      intronic chr6:119025847(-) A-I      intronic chr6:118900253(-) A-I      intronic chr6:118900252(-) A-I      intronic chr6:118900236(-) A-I      intronic chr6:118900232(-) A-I      intronic chr6:118899869(-) A-I      intronic chr6:118899726(-) A-I      intronic chr6:118899710(-) A-I      intronic chr6:118899660(-) A-I      intronic chr6:118894186(-) A-I      intronic chr6:118893683(-) A-I      intronic chr6:118893158(-) A-I      intronic chr6:118893087(-) A-I      intronic chr6:118890357(-) A-I      intronic chr6:118890331(-) A-I      intronic chr6:118875444(-) A-I      intronic chr6:118866566(-) A-I      intronic chr6:118848405(-) A-I      intronic chr6:118985213(-) A-I      intronic chr6:118875606(-) A-I      intronic chr6:118825280(-) A-I      intronic chr6:118821298(-) A-I      intronic chr6:119020611(-) A-I      intronic chr6:118866688(-) A-I      intronic chr6:119024083(-) A-I      intronic chr6:118890422(-) A-I      intronic chr6:118817655(-) A-I      intronic chr6:118900239(-) A-I      intronic chr6:118924264(-) A-I      intronic chr6:118985254(-) A-I      intronic chr6:119003066(-) A-I      intronic chr6:119025724(-) A-I      intronic chr6:118968814(-) A-I      intronic chr6:118899809(-) A-I      intronic chr6:118875214(-) A-I      intronic chr6:118835625(-) A-I      intronic chr6:118982229(-) A-I      intronic chr6:118848423(-) A-I      intronic chr6:118983610(-) A-I      intronic chr6:118899792(-) A-I      intronic chr6:119025766(-) A-I      intronic chr6:118899719(-) A-I      intronic chr6:118836059(-) A-I      intronic chr6:118821418(-) A-I      intronic chr6:118848173(-) A-I      intronic chr6:118890287(-) A-I      intronic chr6:119025771(-) A-I      intronic chr6:118993853(-) A-I      intronic chr6:118836173(-) A-I      intronic chr6:119025914(-) A-I      intronic chr6:119020558(-) A-I      intronic chr6:118893157(-) A-I      intronic chr6:118900325(-) A-I      intronic chr6:119028442(-) A-I      intronic chr6:118983553(-) A-I      intronic chr6:118929469(-) A-I      intronic chr6:118983659(-) A-I      intronic chr6:118819409(-) A-I      intronic chr6:118953352(-) A-I      intronic chr6:118948279(-) A-I      intronic chr6:118992976(-) A-I      intronic chr6:119028495(-) A-I      intronic chr6:118983571(-) A-I      intronic chr6:119020523(-) A-I      intronic chr6:118985196(-) A-I      intronic chr6:118848283(-) A-I      intronic chr6:118983436(-) A-I      intronic chr6:118875585(-) A-I      intronic chr6:119023995(-) A-I      intronic chr6:119023961(-) A-I      intronic chr6:118958604(-) A-I      intronic chr6:118894142(-) A-I      intronic chr6:118983611(-) A-I      intronic chr6:118883790(-) A-I      intronic chr6:118983569(-) A-I      intronic chr6:118982249(-) A-I      intronic chr6:118821301(-) A-I      intronic chr6:118985161(-) A-I      intronic chr6:118985241(-) A-I      intronic chr6:118817682(-) A-I      intronic chr6:118899638(-) A-I      intronic chr6:118924108(-) A-I      intronic chr6:119024037(-) A-I      intronic chr6:118983510(-) A-I      intronic chr6:118890469(-) A-I      intronic chr6:119024096(-) A-I      intronic chr6:119024047(-) A-I      intronic chr6:118899651(-) A-I      intronic chr6:118819422(-) A-I      intronic chr6:119023915(-) A-I      intronic chr6:118805396(-) A-I      intronic chr6:118968728(-) A-I      intronic chr6:118790983(-) A-I      intronic chr6:118993338(-) A-I      intronic chr6:119011207(-) A-I      intronic chr6:118900158(-) A-I      intronic chr6:118848346(-) A-I      intronic chr6:118899713(-) A-I      intronic chr6:118890393(-) A-I      intronic chr6:119028429(-) A-I      intronic chr6:118820635(-) A-I      intronic chr6:118993923(-) A-I      intronic chr6:118900197(-) A-I      intronic chr6:118983434(-) A-I      intronic chr6:118982320(-) A-I      intronic chr6:119023909(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CEP85L	chr6:118983659(-) A-I intron -    22327324 chr6:118818152(-) G-A intron -    22484847 chr6:119007784(-) A-G intron -    22484847 chr6:118810156(-) A-C intron -    22484847 chr6:118817738(-) C-T intron -    22484847 chr6:118835625(-) A-G intron -    22484847 chr6:118835707(-) C-T intron -    22484847 chr6:118836173(-) A-G intron -    22484847 chr6:118848346(-) A-G intron -    22484847 chr6:118856156(-) G-A intron -    22484847 chr6:118890422(-) A-G intron -    22484847 chr6:118893157(-) A-G intron -    22484847 chr6:118893251(-) A-G intron -    22484847 chr6:118894142(-) A-G intron -    22484847 chr6:118899651(-) A-G intron -    22484847 chr6:118899713(-) A-G intron -    22484847 chr6:118899719(-) A-G intron -    22484847 chr6:118899792(-) A-G intron -    22484847 chr6:118899809(-) A-G intron -    22484847 chr6:118900158(-) A-G intron -    22484847 chr6:118900197(-) A-G intron -    22484847 chr6:118900239(-) A-G intron -    22484847 chr6:118900241(-) A-G intron -    22484847 chr6:118900325(-) A-G intron -    22484847 chr6:118916030(-) G-T intron -    22484847 chr6:118929469(-) A-G intron -    22484847 chr6:118949799(-) T-G intron -    22484847 chr6:118949800(-) T-G intron -    22484847 chr6:118949804(-) G-T intron -    22484847 chr6:118953321(-) A-G intron -    22484847 chr6:118953352(-) A-G intron -    22484847 chr6:118953427(-) A-G intron -    22484847 chr6:118968649(-) A-G intron -    22484847 chr6:118968728(-) A-G intron -    22484847 chr6:118968814(-) A-G intron -    22484847 chr6:118982229(-) A-G intron -    22484847 chr6:118982249(-) A-G intron -    22484847 chr6:118982320(-) A-G intron -    22484847 chr6:118982321(-) A-G intron -    22484847 chr6:118983436(-) A-G intron -    22484847 chr6:118983510(-) A-G intron -    22484847 chr6:118983553(-) A-G intron -    22484847 chr6:118983569(-) A-G intron -    22484847 chr6:118983610(-) A-G intron -    22484847 chr6:118983611(-) A-G intron -    22484847 chr6:118983659(-) A-G intron -    22484847 chr6:118992944(-) A-G intron -    22484847 chr6:118993015(-) A-G intron -    22484847 chr6:118993292(-) A-G intron -    22484847 chr6:118993443(-) A-G intron -    22484847 chr6:118993812(-) A-G intron -    22484847 chr6:118993853(-) A-G intron -    22484847 chr6:119011944(-) A-G intron -    22484847 chr6:119012713(-) C-T intron -    22484847 chr6:119020399(-) A-G intron -    22484847 chr6:119020558(-) A-G intron -    22484847 chr6:119020611(-) A-G intron -    22484847 chr6:119023909(-) A-G intron -    22484847 chr6:119023915(-) A-G intron -    22484847 chr6:119023925(-) A-G intron -    22484847 chr6:119023961(-) A-G intron -    22484847 chr6:119024037(-) A-G intron -    22484847 chr6:119024047(-) A-G intron -    22484847 chr6:119024083(-) A-G intron -    22484847 chr6:119024096(-) A-G intron -    22484847 chr6:119025766(-) A-G intron -    22484847 chr6:119025771(-) A-G intron -    22484847 chr6:119025929(-) A-G intron -    22484847 chr6:119028495(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CEP85L	chr6:118786586-118786587(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr6:118786595-118786596(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr6:118786610-118786611(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr6:118786623-118786624(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr6:118786640-118786641(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr6:118786683-118786684(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr6:118786707-118786708(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr6:118786724-118786725(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr6:118790393-118790394(-) m6A CDS       24981863//27773535//27371828//22608085 chr6:118790415-118790416(-) m6A CDS       27773535//27371828//22608085 chr6:118790444-118790445(-) m6A CDS       24981863//27773535//27371828//22608085 chr6:118790457-118790458(-) m6A CDS       24981863//27773535//27371828//22608085 chr6:118791777-118791778(-) m6A CDS       24981863//27773535//22608085 chr6:118801076-118801077(-) m6A CDS       27773535 chr6:118801569-118801570(-) m6A CDS       27773535 chr6:118801582-118801583(-) m6A CDS       27773535 chr6:118801612-118801613(-) m6A CDS       27773535 chr6:118802996-118802997(-) m6A CDS       24981863//27773535 chr6:118803033-118803034(-) m6A CDS       24981863//27773535 chr6:118804930-118804931(-) m6A CDS       27773535 chr6:118804956-118804957(-) m6A CDS       27773535 chr6:118804961-118804962(-) m6A CDS       27773535 chr6:118844996-118844997(-) m6A CDS       27773535 chr6:118886722-118886723(-) m6A CDS//exon       27773535 chr6:118886795-118886796(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr6:118886825-118886826(-) m6A CDS//exon       24284625//24981863//27773535//22608085 chr6:118886892-118886893(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr6:118886953-118886954(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118886964-118886965(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118886995-118886996(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr6:118887031-118887032(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr6:118887067-118887068(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr6:118887119-118887120(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118887228-118887229(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118887265-118887266(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118887274-118887275(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118887286-118887287(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118887307-118887308(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118887317-118887318(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:118887372-118887373(-) m6A CDS//exon       24284625//25456834//24981863//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CEP85L	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: CEP85L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).