Basic Information:

  VIRBase ID:  

HHID00007172

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          GPATCH11:  NM_001371859     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	GPATCH11
miRBase Accession/Entrez ID	MIMAT0004490	253635
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCDC75//CENP-Y//CENPY

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GPATCH11	chr2:37315709(+) A-I      intronic chr2:37315714(+) A-I      intronic chr2:37315855(+) A-I      intronic chr2:37315682(+) A-I      intronic chr2:37315728(+) A-I      intronic chr2:37318642(+) A-I      intronic chr2:37315854(+) A-I      intronic chr2:37316603(+) A-I      intronic chr2:37315762(+) A-I      intronic chr2:37315669(+) A-I      intronic chr2:37315862(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GPATCH11	chr2:37311688-37311689(+) m6A 5'UTR//CDS       24981863 chr2:37315534-37315535(+) m6A 5'UTR//CDS//exon       24981863 chr2:37315546-37315547(+) m1A 5'UTR//CDS//exon       26863196 chr2:37315552-37315553(+) m6A 5'UTR//CDS//exon       24981863 chr2:37316794-37316795(+) m6A CDS//intron       24981863//27773535 chr2:37316871-37316872(+) m6A CDS//intron       24981863//27773535//22608085 chr2:37316899-37316900(+) m6A CDS//intron       24981863//27773535//22608085 chr2:37316946-37316947(+) m6A CDS//intron       24981863//27773535//22608085 chr2:37317839-37317840(+) m6A CDS//intron       24981863 chr2:37317861-37317862(+) m6A CDS//intron       24981863 chr2:37319145-37319146(+) m6A CDS//exon       24981863 chr2:37319170-37319171(+) m6A CDS//exon       24981863 chr2:37321275-37321276(+) m6A CDS//exon       24981863//27773535//22608085 chr2:37321301-37321302(+) m6A CDS//exon       24981863//27773535//22608085 chr2:37323512-37323513(+) m6A 3'UTR       27773535//22608085 chr2:37323596-37323597(+) m6A 3'UTR       24981863//27773535//22608085 chr2:37323617-37323618(+) m6A 3'UTR       24981863//27773535//22575960//22608085 chr2:37323663-37323664(+) m6A 3'UTR       24981863//27773535//22608085 chr2:37323703-37323704(+) m6A 3'UTR       24981863//27773535//22608085 chr2:37323768-37323769(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	GPATCH11	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: GPATCH11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).