Basic Information:

  VIRBase ID:  

HHID00007163

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          CCDC107:  NM_001195200     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	CCDC107
miRBase Accession/Entrez ID	MIMAT0004490	203260
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PSEC0222

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCDC107	chr9:35660409-35660410(+) m6A CDS       - chr9:35660502-35660503(+) m6A 3'UTR//intron       24284625//24981863//27371828 chr9:35660591-35660592(+) m6A 3'UTR//CDS       24284625 chr9:35660607-35660608(+) m6A 3'UTR//CDS       24284625//27773535 chr9:35660628-35660629(+) m6A 3'UTR//CDS       24284625//24981863//27773535 chr9:35660705-35660706(+) m6A 3'UTR//intron       24284625//24981863//27773535 chr9:35660730-35660731(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr9:35660780-35660781(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:35660794-35660795(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:35660828-35660829(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:35660850-35660851(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:35660891-35660892(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:35660905-35660906(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:35660911-35660912(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:35660946-35660947(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:35660960-35660961(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:35661023-35661024(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:35661037-35661038(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:35661044-35661045(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:35661075-35661076(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:35661165-35661166(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr9:35661249-35661250(+) m6A 3'UTR       24981863 chr9:35661285-35661286(+) m6A 3'UTR       24981863 chr9:35661413-35661414(+) m6A 3'UTR       24981863 chr9:35661419-35661420(+) m6A 3'UTR       24981863 chr9:35661452-35661453(+) m6A 3'UTR       24981863 chr9:35661489-35661490(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CCDC107	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: CCDC107

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).