Basic Information:

  VIRBase ID:  

HHID00007129

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          MANEAL:  NM_152496     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	MANEAL
miRBase Accession/Entrez ID	MIMAT0004490	149175
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MANEAL	chr1:38263517(+) A-I      intronic chr1:38263243(+) A-I      intronic chr1:38263068(+) A-I      intronic chr1:38263538(+) A-I      intronic chr1:38263282(+) A-I      intronic chr1:38263556(+) A-I      intronic chr1:38263355(+) A-I      intronic chr1:38263380(+) A-I      intronic chr1:38263657(+) A-I      intronic chr1:38267271(+) A-I      3'UTR chr1:38264510(+) A-I      intronic chr1:38263498(+) A-I      intronic chr1:38263417(+) A-I      intronic chr1:38267110(+) A-I      3'UTR chr1:38262826(+) A-I      intronic chr1:38263456(+) A-I      intronic chr1:38263057(+) A-I      intronic chr1:38263464(+) A-I      intronic chr1:38263385(+) A-I      intronic chr1:38267100(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MANEAL	chr1:38259955-38259956(+) m6A CDS       22575960 chr1:38260164-38260165(+) m6A CDS       24209618 chr1:38260230-38260231(+) m6A CDS       24284625 chr1:38260254-38260255(+) m6A CDS       24284625 chr1:38260353-38260354(+) m6A CDS       24284625 chr1:38261492-38261493(+) m6A CDS       24284625 chr1:38265273-38265274(+) m6A 3'UTR//CDS//intron       24284625//22608085 chr1:38265516-38265517(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:38265534-38265535(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:38265591-38265592(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:38265612-38265613(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:38265761-38265762(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:38265783-38265784(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:38266110-38266111(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:38266141-38266142(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:38266171-38266172(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:38266327-38266328(+) m6A 3'UTR       24284625//24981863//22608085 chr1:38266339-38266340(+) m6A 3'UTR       24284625//24981863 chr1:38266354-38266355(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	MANEAL	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: MANEAL

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).