Basic Information:

  VIRBase ID:  

HHID00007103

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          UPRT:  NR_030774     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	UPRT
miRBase Accession/Entrez ID	MIMAT0004490	139596
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FUR1//UPP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UPRT	chrX:74522424(+) A-I      intronic chrX:74522485(+) A-I      intronic chrX:74522343(+) A-I      intronic chrX:74522474(+) A-I      intronic chrX:74522481(+) A-I      intronic chrX:74522490(+) A-I      intronic chrX:74522435(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UPRT	chrX:74493936-74493937(+) m6A 5'UTR//exon       24981863 chrX:74493962-74493963(+) m6A 5'UTR//exon       24981863 chrX:74494114-74494115(+) m6A CDS//exon       24284625//24209618//22608085 chrX:74494144-74494145(+) m6A CDS//exon       24284625//24209618//22608085 chrX:74494198-74494199(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494213-74494214(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494282-74494283(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494384-74494385(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chrX:74494391-74494392(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chrX:74494401-74494402(+) Cm CDS//exon       - chrX:74519582-74519583(+) m6A 3'UTR//CDS//exon       24981863 chrX:74519596-74519597(+) m6A 3'UTR//CDS//exon       24981863 chrX:74519689-74519690(+) m6A 3'UTR//CDS//exon       24209618 chrX:74523321-74523322(+) m6A 3'UTR//CDS//exon       24981863 chrX:74523935-74523936(+) m6A 3'UTR       - chrX:74524009-74524010(+) m6A 3'UTR       - chrX:74524035-74524036(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	UPRT	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: UPRT

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).