Detail Information

Basic Information:


  VIRBase ID:  

HHID00006871

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:           LRP12:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19a-5p LRP12
miRBase
Accession/Entrez ID		 MIMAT0004490 29967
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MIG13A//ST7

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19a-5p
rs1162564162 chr13:91350912    A/G
rs1170543143 chr13:91350916    T/C
rs1388542964 chr13:91350918    G/C
rs1403138754 chr13:91350923    A/C
rs1442807536 chr13:91350921    C/G
rs764765453 chr13:91350924    CAAG/C
rs1051963210 chr13:91350909    T/C
rs756288295 chr13:91350905    G/A
rs780315531 chr13:91350911    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRP12
chr8:105563830(-) A-I      intronic
chr8:105523357(-) A-I      intronic
chr8:105523332(-) A-I      intronic
chr8:105556112(-) A-I      intronic
chr8:105561854(-) A-I      intronic
chr8:105523423(-) A-I      intronic
chr8:105524462(-) A-I      intronic
chr8:105561911(-) A-I      intronic
chr8:105524397(-) A-I      intronic
chr8:105561089(-) A-I      intronic
chr8:105560934(-) A-I      intronic
chr8:105524463(-) A-I      intronic
chr8:105561859(-) A-I      intronic
chr8:105560935(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRP12
chr8:105501915-105501916(-) m6A 3'UTR//exon       27773535
chr8:105502047-105502048(-) m6A 3'UTR//exon       27773535
chr8:105502825-105502826(-) m6A 3'UTR//exon       24981863//27773535
chr8:105502964-105502965(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503059-105503060(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503071-105503072(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503101-105503102(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503126-105503127(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503206-105503207(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503222-105503223(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503335-105503336(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503513-105503514(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:105503569-105503570(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr8:105503669-105503670(-) m6A CDS//exon       24209618//24981863//22608085
chr8:105509400-105509401(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509439-105509440(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509557-105509558(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509735-105509736(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509864-105509865(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509910-105509911(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:105509949-105509950(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:105510021-105510022(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:105510054-105510055(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:105510290-105510291(-) m6A CDS//exon       24209618
chr8:105518064-105518065(-) m6A exon//intron       27773535
chr8:105518085-105518086(-) m6A exon//intron       27773535
chr8:105518094-105518095(-) m6A exon//intron       27773535
chr8:105518999-105519000(-) m6A exon//intron       27773535
chr8:105519053-105519054(-) m6A exon//intron       27773535
chr8:105519067-105519068(-) m6A exon//intron       27773535
chr8:105519079-105519080(-) m6A exon//intron       27773535
chr8:105519099-105519100(-) m6A exon//intron       27773535
chr8:105521290-105521291(-) m6A CDS//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
LRP12
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19a-5p
Interactor2: LRP12

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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