Basic Information:

  VIRBase ID:  

HHID00006776

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          ARPC5:  NM_001270439     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	ARPC5
miRBase Accession/Entrez ID	MIMAT0004490	10092
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARC16//dJ127C7.3//p16-Arc

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARPC5	chr1:183596201-183596202(-) m6A 3'UTR//exon//intron       26404942 chr1:183596206-183596207(-) m6A 3'UTR//exon//intron       26404942 chr1:183596230-183596231(-) m6A 3'UTR//exon//intron       26404942 chr1:183596607-183596608(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596613-183596614(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596674-183596675(-) m6A CDS//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183599692-183599693(-) m6A CDS//exon       26404942 chr1:183599770-183599771(-) m6A CDS//exon       27773536//22575960 chr1:183599823-183599824(-) m6A exon//intron       27773536//22575960 chr1:183599840-183599841(-) m6A exon//intron       27773536 chr1:183599915-183599916(-) m6A exon//intron       - chr1:183599952-183599953(-) m6A exon//intron       27773535 chr1:183599961-183599962(-) m6A exon//intron       27773535 chr1:183600079-183600080(-) m6A exon//intron       27773535 chr1:183600118-183600119(-) m6A exon//intron       27773535 chr1:183602204-183602205(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602250-183602251(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602283-183602284(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602351-183602352(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602401-183602402(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602428-183602429(-) m6A exon//intron       25456834//27773536 chr1:183603045-183603046(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603053-183603054(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603087-183603088(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604666-183604667(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604711-183604712(-) m1A CDS       26863196//26863410 chr1:183604729-183604730(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:183604783-183604784(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ARPC5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: ARPC5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).