Detail Information

Basic Information:


  VIRBase ID:  

HHID00006760

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:           BAG2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19a-5p BAG2
miRBase
Accession/Entrez ID		 MIMAT0004490 9532
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BAG-2//dJ417I1.2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19a-5p
rs1162564162 chr13:91350912    A/G
rs1170543143 chr13:91350916    T/C
rs1388542964 chr13:91350918    G/C
rs1403138754 chr13:91350923    A/C
rs1442807536 chr13:91350921    C/G
rs764765453 chr13:91350924    CAAG/C
rs1051963210 chr13:91350909    T/C
rs756288295 chr13:91350905    G/A
rs780315531 chr13:91350911    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BAG2
chr6:57046418(+) A-I      intronic
chr6:57046375(+) A-I      intronic
chr6:57046476(+) A-I      intronic
chr6:57046410(+) A-I      intronic
chr6:57046378(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BAG2
chr6:57037185-57037186(+) m6A 5'UTR       24284625//24981863//22575960
chr6:57037245-57037246(+) m6A 5'UTR       24284625//24981863//22575960
chr6:57046918-57046919(+) m6A CDS       24209618//24981863//27773535//22608085
chr6:57048605-57048606(+) m6A CDS       24209618//24981863//26404942//27773535//22608085
chr6:57048622-57048623(+) m6A CDS       24209618//24981863//26404942//27773535//22608085
chr6:57048649-57048650(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr6:57048659-57048660(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr6:57048845-57048846(+) Am CDS       -
chr6:57048877-57048878(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr6:57048899-57048900(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr6:57048952-57048953(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr6:57048995-57048996(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr6:57049156-57049157(+) m6A 3'UTR       -
chr6:57049212-57049213(+) Y 3'UTR       25219674
chr6:57049269-57049270(+) m6A 3'UTR       -
chr6:57049446-57049447(+) m6A 3'UTR       27773535
chr6:57049563-57049564(+) m6A 3'UTR       27773535
chr6:57049584-57049585(+) m6A 3'UTR       27773535
chr6:57049608-57049609(+) m6A 3'UTR       27773535
chr6:57049910-57049911(+) Y 3'UTR       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
BAG2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19a-5p
Interactor2: BAG2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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