Detail Information

Basic Information:


  VIRBase ID:  

HHID00006732

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:           PLPP3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19a-5p PLPP3
miRBase
Accession/Entrez ID		 MIMAT0004490 8613
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Dri42//LPP3//PAP2B//PPAP2B//VCIP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19a-5p
rs1162564162 chr13:91350912    A/G
rs1170543143 chr13:91350916    T/C
rs1388542964 chr13:91350918    G/C
rs1403138754 chr13:91350923    A/C
rs1442807536 chr13:91350921    C/G
rs764765453 chr13:91350924    CAAG/C
rs1051963210 chr13:91350909    T/C
rs756288295 chr13:91350905    G/A
rs780315531 chr13:91350911    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLPP3
chr1:57040110(-) A-I      intronic
chr1:57040092(-) A-I      intronic
chr1:57040097(-) A-I      intronic
chr1:57040178(-) A-I      intronic
chr1:57039790(-) A-I      intronic
chr1:57039745(-) A-I      intronic
chr1:57040091(-) A-I      intronic
chr1:57040180(-) A-I      intronic
chr1:57039680(-) A-I      intronic
chr1:57040201(-) A-I      intronic
chr1:57040155(-) A-I      intronic
chr1:57039681(-) A-I      intronic
chr1:57039690(-) A-I      intronic
chr1:57039701(-) A-I      intronic
chr1:57039707(-) A-I      intronic
chr1:57039725(-) A-I      intronic
chr1:57039729(-) A-I      intronic
chr1:57040141(-) A-I      intronic
chr1:57008545(-) A-I      intronic
chr1:56984441(-) A-I      intronic
chr1:56969934(-) A-I      intronic
chr1:56969717(-) A-I      intronic
chr1:56969711(-) A-I      intronic
chr1:57008546(-) A-I      intronic
chr1:56966494(-) A-I      intronic
chr1:57022504(-) A-I      intronic
chr1:56969662(-) A-I      intronic
chr1:56969560(-) A-I      intronic
chr1:56969559(-) A-I      intronic
chr1:56969217(-) A-I      intronic
chr1:56966576(-) A-I      intronic
chr1:57035117(-) A-I      intronic
chr1:57040174(-) A-I      intronic
chr1:57040131(-) A-I      intronic
chr1:57040104(-) A-I      intronic
chr1:57040103(-) A-I      intronic
chr1:57039870(-) A-I      intronic
chr1:57034983(-) A-I      intronic
chr1:57027584(-) A-I      intronic
chr1:57026649(-) A-I      intronic
chr1:57026648(-) A-I      intronic
chr1:57039630(-) A-I      intronic
chr1:57026622(-) A-I      intronic
chr1:57026573(-) A-I      intronic
chr1:57026558(-) A-I      intronic
chr1:57026541(-) A-I      intronic
chr1:57025204(-) A-I      intronic
chr1:57022551(-) A-I      intronic
chr1:57022512(-) A-I      intronic
chr1:57021428(-) A-I      intronic
chr1:57039851(-) A-I      intronic
chr1:57026563(-) A-I      intronic
chr1:57039618(-) A-I      intronic
chr1:57035124(-) A-I      intronic
chr1:57035118(-) A-I      intronic
chr1:57026639(-) A-I      intronic
chr1:57027541(-) A-I      intronic
chr1:56969261(-) A-I      intronic
chr1:57039710(-) A-I      intronic
chr1:57039842(-) A-I      intronic
chr1:57027672(-) A-I      intronic
chr1:57040066(-) A-I      intronic
chr1:57021456(-) A-I      intronic
chr1:56969663(-) A-I      intronic
chr1:57040200(-) A-I      intronic
chr1:57039834(-) A-I      intronic
chr1:56978049(-) A-I      ncRNA
chr1:56978092(-) A-I      ncRNA
chr1:56969212(-) A-I      intronic
chr1:56964484(-) A-I      intronic
chr1:56986301(-) A-I      intronic
chr1:57022474(-) A-I      intronic
chr1:57040234(-) A-I      intronic
chr1:56969556(-) A-I      intronic
chr1:56966432(-) A-I      intronic
chr1:56969338(-) A-I      intronic
chr1:56969703(-) A-I      intronic
chr1:57027442(-) A-I      intronic
chr1:57020032(-) A-I      intronic
chr1:57039685(-) A-I      intronic
chr1:56969554(-) A-I      intronic
chr1:56969634(-) A-I      intronic
chr1:56969482(-) A-I      intronic
chr1:57022531(-) A-I      intronic
chr1:56969118(-) A-I      intronic
chr1:57027586(-) A-I      intronic
chr1:57019989(-) A-I      intronic
chr1:56969117(-) A-I      intronic
chr1:56964483(-) A-I      intronic
chr1:57027542(-) A-I      intronic
chr1:56987320(-) A-I      intronic
chr1:57031367(-) A-I      intronic
chr1:56969954(-) A-I      intronic
chr1:56969116(-) A-I      intronic
chr1:57031383(-) A-I      intronic
chr1:57039749(-) A-I      intronic
chr1:57022477(-) A-I      intronic
chr1:57021401(-) A-I      intronic
chr1:57040020(-) A-I      intronic
chr1:57026792(-) A-I      intronic
chr1:56969619(-) A-I      intronic
chr1:57040127(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLPP3
chr1:56962125-56962126(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr1:56962145-56962146(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr1:56962244-56962245(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr1:56962259-56962260(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr1:56962320-56962321(-) m6A CDS//exon       24209618//24981863//26404942//27773535
chr1:56977714-56977715(-) m6A CDS//exon       27773535
chr1:56977731-56977732(-) m6A CDS//exon       27773535
chr1:57002679-57002680(-) m6A CDS//exon       27773535
chr1:57002688-57002689(-) m6A CDS//exon       27773535
chr1:57002757-57002758(-) m6A CDS//exon       27773535
chr1:57044681-57044682(-) m6A CDS//intron       27773536
chr1:57044872-57044873(-) m6A 5'UTR//exon//intron       25456834//24981863//26404942//27371828//27773536//22608085
chr1:57044930-57044931(-) m6A 5'UTR//exon//intron       25456834//24981863//26404942//27371828//27773536//22608085
chr1:57045071-57045072(-) m6A 5'UTR//exon//intron       25456834//24981863//27773536//22608085
chr1:57045226-57045227(-) m6A 5'UTR//exon//intron       24981863
chr1:57045230-57045231(-) m6A 5'UTR//exon//intron       27773535
chr1:57109157-57109158(-) m6A exon//intron       27773535
chr1:57109209-57109210(-) m6A exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PLPP3
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19a-5p
Interactor2: PLPP3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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