Basic Information:

  VIRBase ID:  

HHID00006696

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          TFAM:  NR_073073     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	TFAM
miRBase Accession/Entrez ID	MIMAT0004490	7019
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MTDPS15//MTTF1//MTTFA//TCF6//TCF6L1//TCF6L2//TCF6L3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TFAM	chr10:60152699(+) A-I      intronic chr10:60153399(+) A-I      intronic chr10:60153410(+) A-I      intronic chr10:60152641(+) A-I      intronic chr10:60153561(+) A-I      intronic chr10:60153445(+) A-I      intronic chr10:60152568(+) A-I      intronic chr10:60153470(+) A-I      intronic chr10:60153528(+) A-I      intronic chr10:60157650(+) A-I      3'UTR chr10:60152547(+) A-I      intronic chr10:60152892(+) A-I      intronic chr10:60153552(+) A-I      intronic chr10:60152646(+) A-I      intronic chr10:60153570(+) A-I      intronic chr10:60152553(+) A-I      intronic chr10:60153612(+) A-I      intronic chr10:60153469(+) A-I      intronic chr10:60152633(+) A-I      intronic chr10:60152619(+) A-I      intronic chr10:60153462(+) A-I      intronic chr10:60153580(+) A-I      intronic chr10:60152897(+) A-I      intronic chr10:60153461(+) A-I      intronic chr10:60152564(+) A-I      intronic chr10:60157781(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TFAM	chr10:60147998-60147999(+) m6A CDS//exon       24981863 chr10:60148494-60148495(+) m6A CDS//exon       24981863//27773535 chr10:60148541-60148542(+) m6A CDS//exon       27773535 chr10:60150544-60150545(+) m6A CDS//exon//intron       27773535 chr10:60150553-60150554(+) m6A CDS//exon//intron       27773535 chr10:60154129-60154130(+) m6A CDS//exon       27773535 chr10:60154142-60154143(+) m6A CDS//exon       27773535 chr10:60154259-60154260(+) m6A CDS//intron       24981863 chr10:60154717-60154718(+) m6A CDS//exon       24981863//27773535 chr10:60154752-60154753(+) m6A CDS//exon       24981863//27773535 chr10:60154803-60154804(+) m6A CDS//exon       24981863//27773535 chr10:60154877-60154878(+) m6A 3'UTR//exon       24981863//26404942 chr10:60154936-60154937(+) m6A 3'UTR//exon       24284625//24981863//26404942//22608085 chr10:60154973-60154974(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr10:60155004-60155005(+) m6A 3'UTR       24981863//26404942//22608085 chr10:60155026-60155027(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr10:60155046-60155047(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr10:60155111-60155112(+) m6A 3'UTR       24981863//27773535//22608085 chr10:60155163-60155164(+) Y 3'UTR       26075521 chr10:60158622-60158623(+) m6A 3'UTR       24981863//27773535 chr10:60158649-60158650(+) m6A 3'UTR       24981863//27773535 chr10:60158677-60158678(+) m6A 3'UTR       24981863//27773535 chr10:60158702-60158703(+) m6A 3'UTR       24981863//27773535 chr10:60158767-60158768(+) m6A 3'UTR       27773535 chr10:60158814-60158815(+) m6A 3'UTR       27773535 chr10:60158866-60158867(+) m6A 3'UTR       27773535 chr10:60158940-60158941(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TFAM	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: TFAM

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).