Detail Information

Basic Information:


  VIRBase ID:  

HHID00006692

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:           MAP3K7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-19a-5p MAP3K7
miRBase
Accession/Entrez ID		 MIMAT0004490 6885
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CSCF//FMD2//MEKK7//TAK1//TGF1a

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-19a-5p
rs1162564162 chr13:91350912    A/G
rs1170543143 chr13:91350916    T/C
rs1388542964 chr13:91350918    G/C
rs1403138754 chr13:91350923    A/C
rs1442807536 chr13:91350921    C/G
rs764765453 chr13:91350924    CAAG/C
rs1051963210 chr13:91350909    T/C
rs756288295 chr13:91350905    G/A
rs780315531 chr13:91350911    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAP3K7
chr6:91285975(-) A-I      intronic
chr6:91288122(-) A-I      intronic
chr6:91288126(-) A-I      intronic
chr6:91296044(-) A-I      intronic
chr6:91292687(-) A-I      intronic
chr6:91285994(-) A-I      intronic
chr6:91285993(-) A-I      intronic
chr6:91286079(-) A-I      intronic
chr6:91288030(-) A-I      intronic
chr6:91288057(-) A-I      intronic
chr6:91288158(-) A-I      intronic
chr6:91288187(-) A-I      intronic
chr6:91288189(-) A-I      intronic
chr6:91288197(-) A-I      intronic
chr6:91288213(-) A-I      intronic
chr6:91290290(-) A-I      intronic
chr6:91290311(-) A-I      intronic
chr6:91292605(-) A-I      intronic
chr6:91292694(-) A-I      intronic
chr6:91295902(-) A-I      intronic
chr6:91296045(-) A-I      intronic
chr6:91288164(-) A-I      intronic
chr6:91296028(-) A-I      intronic
chr6:91285973(-) A-I      intronic
chr6:91290318(-) A-I      intronic
chr6:91241421(-) A-I      intronic
chr6:91286020(-) A-I      intronic
chr6:91290312(-) A-I      intronic
chr6:91292833(-) A-I      intronic
chr6:91288131(-) A-I      intronic
chr6:91237189(-) A-I      intronic
chr6:91288190(-) A-I      intronic
chr6:91241427(-) A-I      intronic
chr6:91288132(-) A-I      intronic
chr6:91285961(-) A-I      intronic
chr6:91241527(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MAP3K7
chr6:91288236(-) A-I intron -    21960545
chr6:91235141(-) G-T intron -    22484847
chr6:91241421(-) A-G intron -    22484847
chr6:91285961(-) A-G intron -    22484847
chr6:91286020(-) A-G intron -    22484847
chr6:91286095(-) A-G intron -    22484847
chr6:91288131(-) A-G intron -    22484847
chr6:91288132(-) A-G intron -    22484847
chr6:91288152(-) G-A intron -    22484847
chr6:91288190(-) A-G intron -    22484847
chr6:91288236(-) A-G intron -    22484847
chr6:91290318(-) A-G intron -    22484847
chr6:91292833(-) A-G intron -    22484847
chr6:91254873(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAP3K7
chr6:91225007-91225008(-) m6A 3'UTR       27773535
chr6:91225016-91225017(-) m6A 3'UTR       27773535
chr6:91225060-91225061(-) m6A 3'UTR       27773535//22608085
chr6:91225249-91225250(-) m6A 3'UTR       24981863//27773535//22608085
chr6:91225286-91225287(-) m6A 3'UTR       24981863//27773535//22608085
chr6:91225417-91225418(-) m6A 3'UTR//exon       27773535
chr6:91225476-91225477(-) m6A 3'UTR//exon       27773535
chr6:91225537-91225538(-) m6A 3'UTR//exon       27773535
chr6:91225547-91225548(-) m6A 3'UTR//exon       27773535
chr6:91225573-91225574(-) m6A 3'UTR//exon       27773535
chr6:91225654-91225655(-) m6A 3'UTR//exon       27773535//22608085
chr6:91225713-91225714(-) m6A 3'UTR//exon       27773535//22608085
chr6:91225764-91225765(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr6:91225848-91225849(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr6:91225879-91225880(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr6:91225897-91225898(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr6:91225911-91225912(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr6:91225959-91225960(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr6:91225972-91225973(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:91226048-91226049(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr6:91226156-91226157(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:91226179-91226180(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:91226209-91226210(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr6:91226270-91226271(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr6:91226307-91226308(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr6:91226330-91226331(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr6:91226361-91226362(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91226376-91226377(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91226381-91226382(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91226393-91226394(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr6:91228193-91228194(-) m6A CDS//exon//intron       24284625//27773535//22608085
chr6:91228233-91228234(-) m6A CDS//exon//intron       27773535
chr6:91228261-91228262(-) m6A CDS//exon//intron       27773535
chr6:91233414-91233415(-) m6A CDS//exon       27773535
chr6:91233451-91233452(-) m6A CDS//exon       27773535
chr6:91246064-91246065(-) m6A CDS//exon       27773535
chr6:91246069-91246070(-) m6A CDS//exon       27773535
chr6:91246086-91246087(-) m6A CDS//exon       27773535
chr6:91246112-91246113(-) m6A CDS//exon       27773535
chr6:91263221-91263222(-) Gm CDS       -
chr6:91296709-91296710(-) m6A 5'UTR       24981863//27371828//27773536
chr6:91296761-91296762(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-19a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MAP3K7
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-19a-5p
Interactor2: MAP3K7

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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