Basic Information:

  VIRBase ID:  

HHID00006681

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          SH3GL2:  NM_003026     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	SH3GL2
miRBase Accession/Entrez ID	MIMAT0004490	6456
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CNSA2//EEN-B1//SH3D2A//SH3P4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SH3GL2	chr9:17675782(+) A-I      intronic chr9:17581796(+) A-I      intronic chr9:17675785(+) A-I      intronic chr9:17675784(+) A-I      intronic chr9:17590960(+) A-I      intronic chr9:17590881(+) A-I      intronic chr9:17747869(+) A-I      intronic chr9:17755535(+) A-I      intronic chr9:17768101(+) A-I      intronic chr9:17758457(+) A-I      intronic chr9:17718605(+) A-I      intronic chr9:17605186(+) A-I      intronic chr9:17605071(+) A-I      intronic chr9:17605034(+) A-I      intronic chr9:17784898(+) A-I      intronic chr9:17692523(+) A-I      intronic chr9:17758481(+) A-I      intronic chr9:17587711(+) A-I      intronic chr9:17587139(+) A-I      intronic chr9:17587035(+) A-I      intronic chr9:17768249(+) A-I      intronic chr9:17587023(+) A-I      intronic chr9:17676451(+) A-I      intronic chr9:17699042(+) A-I      intronic chr9:17605051(+) A-I      intronic chr9:17784912(+) A-I      intronic chr9:17587755(+) A-I      intronic chr9:17758349(+) A-I      intronic chr9:17758413(+) A-I      intronic chr9:17752546(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SH3GL2	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: SH3GL2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).