Basic Information:

  VIRBase ID:  

HHID00006642

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          PHYH:  NM_001323083     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	PHYH
miRBase Accession/Entrez ID	MIMAT0004490	5264
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LN1//LNAP1//PAHX//PHYH1//RD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PHYH	chr10:13331226(-) A-I      intronic chr10:13340601(-) A-I      intronic chr10:13331248(-) A-I      intronic chr10:13335479(-) A-I      intronic chr10:13335478(-) A-I      intronic chr10:13331268(-) A-I      intronic chr10:13335378(-) A-I      intronic chr10:13331855(-) A-I      intronic chr10:13332973(-) A-I      intronic chr10:13330045(-) A-I      intronic chr10:13327244(-) A-I      intronic chr10:13335341(-) A-I      intronic chr10:13340667(-) A-I      intronic chr10:13332985(-) A-I      intronic chr10:13334676(-) A-I      intronic chr10:13332664(-) A-I      intronic chr10:13331360(-) A-I      intronic chr10:13330012(-) A-I      intronic chr10:13333768(-) A-I      intronic chr10:13335466(-) A-I      intronic chr10:13329997(-) A-I      intronic chr10:13333730(-) A-I      intronic chr10:13333635(-) A-I      intronic chr10:13332914(-) A-I      intronic chr10:13333601(-) A-I      intronic chr10:13325294(-) A-I      intronic chr10:13330665(-) A-I      intronic chr10:13330104(-) A-I      intronic chr10:13329300(-) A-I      intronic chr10:13333679(-) A-I      intronic chr10:13327383(-) A-I      intronic chr10:13333751(-) A-I      intronic chr10:13331774(-) A-I      intronic chr10:13331809(-) A-I      intronic chr10:13331334(-) A-I      intronic chr10:13327729(-) A-I      intronic chr10:13331396(-) A-I      intronic chr10:13329308(-) A-I      intronic chr10:13330097(-) A-I      intronic chr10:13331715(-) A-I      intronic chr10:13335484(-) A-I      intronic chr10:13327996(-) A-I      intronic chr10:13328546(-) A-I      intronic chr10:13337189(-) A-I      intronic chr10:13327348(-) A-I      intronic chr10:13325268(-) A-I      intronic chr10:13330672(-) A-I      intronic chr10:13331234(-) A-I      intronic chr10:13332925(-) A-I      intronic chr10:13331937(-) A-I      intronic chr10:13328615(-) A-I      intronic chr10:13330703(-) A-I      intronic chr10:13335475(-) A-I      intronic chr10:13333563(-) A-I      intronic chr10:13333577(-) A-I      intronic chr10:13333078(-) A-I      intronic chr10:13331933(-) A-I      intronic chr10:13336302(-) A-I      intronic chr10:13329227(-) A-I      intronic chr10:13331714(-) A-I      intronic chr10:13330717(-) A-I      intronic chr10:13334881(-) A-I      intronic chr10:13332660(-) A-I      intronic chr10:13333617(-) A-I      intronic chr10:13340416(-) A-I      intronic chr10:13328010(-) A-I      intronic chr10:13325093(-) A-I      intronic chr10:13333572(-) A-I      intronic chr10:13329295(-) A-I      intronic chr10:13327357(-) A-I      intronic chr10:13330714(-) A-I      intronic chr10:13320818(-) A-I      intronic chr10:13331225(-) A-I      intronic chr10:13331749(-) A-I      intronic chr10:13335707(-) A-I      intronic chr10:13340417(-) A-I      intronic chr10:13339568(-) A-I      intronic chr10:13331697(-) A-I      intronic chr10:13330798(-) A-I      intronic chr10:13336323(-) A-I      intronic chr10:13323998(-) A-I      intronic chr10:13330828(-) A-I      intronic chr10:13328131(-) A-I      intronic chr10:13331764(-) A-I      intronic chr10:13333738(-) A-I      intronic chr10:13327295(-) A-I      intronic chr10:13328614(-) A-I      intronic chr10:13330802(-) A-I      intronic chr10:13335685(-) A-I      intronic chr10:13327450(-) A-I      intronic chr10:13327620(-) A-I      intronic chr10:13330031(-) A-I      intronic chr10:13334770(-) A-I      intronic chr10:13330661(-) A-I      intronic chr10:13334682(-) A-I      intronic chr10:13335400(-) A-I      intronic chr10:13333707(-) A-I      intronic chr10:13340699(-) A-I      intronic chr10:13329176(-) A-I      intronic chr10:13324340(-) A-I      intronic chr10:13333063(-) A-I      intronic chr10:13333545(-) A-I      intronic chr10:13333752(-) A-I      intronic chr10:13335666(-) A-I      intronic chr10:13324063(-) A-I      intronic chr10:13335325(-) A-I      intronic chr10:13331876(-) A-I      intronic chr10:13331468(-) A-I      intronic chr10:13327459(-) A-I      intronic chr10:13322501(-) A-I      intronic chr10:13332840(-) A-I      intronic chr10:13332988(-) A-I      intronic chr10:13333765(-) A-I      intronic chr10:13335623(-) A-I      intronic chr10:13331228(-) A-I      intronic chr10:13333639(-) A-I      intronic chr10:13327769(-) A-I      intronic chr10:13328064(-) A-I      intronic chr10:13331729(-) A-I      intronic chr10:13333607(-) A-I      intronic chr10:13335364(-) A-I      intronic chr10:13332984(-) A-I      intronic chr10:13329923(-) A-I      intronic chr10:13334767(-) A-I      intronic chr10:13340450(-) A-I      intronic chr10:13330834(-) A-I      intronic chr10:13327457(-) A-I      intronic chr10:13327743(-) A-I      intronic chr10:13329191(-) A-I      intronic chr10:13335495(-) A-I      intronic chr10:13330613(-) A-I      intronic chr10:13331819(-) A-I      intronic chr10:13331759(-) A-I      intronic chr10:13324386(-) A-I      intronic chr10:13335684(-) A-I      intronic chr10:13335340(-) A-I      intronic chr10:13327871(-) A-I      intronic chr10:13327938(-) A-I      intronic chr10:13330770(-) A-I      intronic chr10:13331766(-) A-I      intronic chr10:13320812(-) A-I      intronic chr10:13331675(-) A-I      intronic chr10:13332975(-) A-I      intronic chr10:13328005(-) A-I      intronic chr10:13336328(-) A-I      intronic chr10:13329935(-) A-I      intronic chr10:13329173(-) A-I      intronic chr10:13333725(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PHYH	chr10:13332660(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PHYH	chr10:13330432-13330433(-) m6A CDS       - chr10:13330507-13330508(-) m6A CDS       - chr10:13344009-13344010(-) m6A 5'UTR       24981863 chr10:13344018-13344019(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PHYH	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: PHYH

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).