Basic Information:

  VIRBase ID:  

HHID00006574

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-19a-5p:  MIMAT0004490          S1PR1:  NM_001400     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-19a-5p	S1PR1
miRBase Accession/Entrez ID	MIMAT0004490	1901
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD363//CHEDG1//D1S3362//ECGF1//EDG-1//EDG1//S1P1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-19a-5p	rs1162564162 chr13:91350912    A/G rs1170543143 chr13:91350916    T/C rs1388542964 chr13:91350918    G/C rs1403138754 chr13:91350923    A/C rs1442807536 chr13:91350921    C/G rs764765453 chr13:91350924    CAAG/C rs1051963210 chr13:91350909    T/C rs756288295 chr13:91350905    G/A rs780315531 chr13:91350911    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	S1PR1	chr1:101702480-101702481(+) m6A 5'UTR       - chr1:101702499-101702500(+) m6A 5'UTR//exon       - chr1:101702535-101702536(+) m6A 5'UTR//exon       - chr1:101704658-101704659(+) m6A CDS//exon       22608085 chr1:101704667-101704668(+) m6A CDS//exon       24981863//22608085 chr1:101704677-101704678(+) m6A CDS//exon       24981863//22608085 chr1:101704727-101704728(+) m6A CDS//exon       24981863//22608085 chr1:101704756-101704757(+) m6A CDS//exon       24981863//22608085 chr1:101704811-101704812(+) m6A CDS//exon       24981863//22608085 chr1:101704989-101704990(+) m6A CDS//exon       24981863//22608085 chr1:101705087-101705088(+) m6A CDS       24981863//22608085 chr1:101705227-101705228(+) m6A CDS       24981863 chr1:101705258-101705259(+) m6A CDS       24981863 chr1:101705308-101705309(+) m6A CDS       - chr1:101705395-101705396(+) m6A CDS       - chr1:101705543-101705544(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705606-101705607(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705639-101705640(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705650-101705651(+) m6A CDS       25456834//24981863//22608085 chr1:101705690-101705691(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101705828-101705829(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101705875-101705876(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101706012-101706013(+) m6A 3'UTR       24981863 chr1:101706085-101706086(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-19a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	S1PR1	Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-19a-5p
Interactor2: S1PR1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).