Basic Information:

  VIRBase ID:  

HHID00006401

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519e-3p:  MIMAT0002829          MXRA7:  NM_001008528     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519e-3p	MXRA7
miRBase Accession/Entrez ID	MIMAT0002829	439921
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519e-3p	rs1320260913 chr19:53680012    T/TA rs748109530 chr19:53680008    G/A rs756692397 chr19:53679994    T/C rs762638742 chr19:53679970    CTTTCTGTTTGAAAGAAAACAAAGTGCCTCCTTTTAGAGTG/C rs778834695 chr19:53679997    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MXRA7	chr17:74686927(-) A-I      intronic chr17:74703508(-) A-I      intronic chr17:74703665(-) A-I      intronic chr17:74673192(-) A-I      3'UTR chr17:74698481(-) A-I      intronic chr17:74698497(-) A-I      intronic chr17:74692055(-) A-I      intronic chr17:74692069(-) A-I      intronic chr17:74692053(-) A-I      intronic chr17:74688382(-) A-I      intronic chr17:74698478(-) A-I      intronic chr17:74692049(-) A-I      intronic chr17:74685969(-) A-I      intronic chr17:74685970(-) A-I      intronic chr17:74685971(-) A-I      intronic chr17:74686918(-) A-I      intronic chr17:74692478(-) A-I      intronic chr17:74692535(-) A-I      intronic chr17:74690793(-) A-I      intronic chr17:74689405(-) A-I      intronic chr17:74689410(-) A-I      intronic chr17:74689464(-) A-I      intronic chr17:74689484(-) A-I      intronic chr17:74690788(-) A-I      intronic chr17:74690765(-) A-I      intronic chr17:74689840(-) A-I      intronic chr17:74689828(-) A-I      intronic chr17:74689702(-) A-I      intronic chr17:74689495(-) A-I      intronic chr17:74690671(-) A-I      intronic chr17:74692534(-) A-I      intronic chr17:74690841(-) A-I      intronic chr17:74690837(-) A-I      intronic chr17:74690836(-) A-I      intronic chr17:74690835(-) A-I      intronic chr17:74690806(-) A-I      intronic chr17:74689402(-) A-I      intronic chr17:74692508(-) A-I      intronic chr17:74692399(-) A-I      intronic chr17:74692077(-) A-I      intronic chr17:74692065(-) A-I      intronic chr17:74692562(-) A-I      intronic chr17:74692033(-) A-I      intronic chr17:74691983(-) A-I      intronic chr17:74691074(-) A-I      intronic chr17:74690856(-) A-I      intronic chr17:74690852(-) A-I      intronic chr17:74698785(-) A-I      intronic chr17:74688614(-) A-I      intronic chr17:74698546(-) A-I      intronic chr17:74698540(-) A-I      intronic chr17:74698538(-) A-I      intronic chr17:74698466(-) A-I      intronic chr17:74698458(-) A-I      intronic chr17:74696326(-) A-I      intronic chr17:74696222(-) A-I      intronic chr17:74688608(-) A-I      intronic chr17:74688607(-) A-I      intronic chr17:74688508(-) A-I      intronic chr17:74688412(-) A-I      intronic chr17:74696217(-) A-I      intronic chr17:74688253(-) A-I      intronic chr17:74688215(-) A-I      intronic chr17:74686934(-) A-I      intronic chr17:74686922(-) A-I      intronic chr17:74686913(-) A-I      intronic chr17:74686905(-) A-I      intronic chr17:74695441(-) A-I      intronic chr17:74686887(-) A-I      intronic chr17:74686562(-) A-I      intronic chr17:74686540(-) A-I      intronic chr17:74685877(-) A-I      intronic chr17:74685441(-) A-I      intronic chr17:74685388(-) A-I      intronic chr17:74685350(-) A-I      intronic chr17:74695088(-) A-I      intronic chr17:74695084(-) A-I      intronic chr17:74694953(-) A-I      intronic chr17:74694913(-) A-I      intronic chr17:74694902(-) A-I      intronic chr17:74694881(-) A-I      intronic chr17:74694835(-) A-I      intronic chr17:74686901(-) A-I      intronic chr17:74685283(-) A-I      intronic chr17:74688404(-) A-I      intronic chr17:74672745(-) A-I      3'UTR chr17:74673118(-) A-I      3'UTR chr17:74672883(-) A-I      3'UTR chr17:74673207(-) A-I      3'UTR chr17:74673203(-) A-I      3'UTR chr17:74672857(-) A-I      3'UTR chr17:74673336(-) A-I      3'UTR chr17:74673183(-) A-I      3'UTR chr17:74672763(-) A-I      3'UTR chr17:74672665(-) A-I      3'UTR chr17:74672696(-) A-I      3'UTR chr17:74673305(-) A-I      3'UTR chr17:74672762(-) A-I      3'UTR chr17:74673274(-) A-I      3'UTR chr17:74672682(-) A-I      3'UTR chr17:74673145(-) A-I      3'UTR chr17:74673239(-) A-I      3'UTR chr17:74673130(-) A-I      3'UTR chr17:74672679(-) A-I      3'UTR chr17:74673265(-) A-I      3'UTR chr17:74672588(-) A-I      3'UTR chr17:74673212(-) A-I      3'UTR chr17:74673226(-) A-I      3'UTR chr17:74673225(-) A-I      3'UTR chr17:74673218(-) A-I      3'UTR chr17:74672736(-) A-I      3'UTR chr17:74672733(-) A-I      3'UTR chr17:74672723(-) A-I      3'UTR chr17:74672701(-) A-I      3'UTR chr17:74690751(-) A-I      intronic chr17:74685863(-) A-I      intronic chr17:74685378(-) A-I      intronic chr17:74690668(-) A-I      intronic chr17:74685421(-) A-I      intronic chr17:74696232(-) A-I      intronic chr17:74685300(-) A-I      intronic chr17:74685832(-) A-I      intronic chr17:74685878(-) A-I      intronic chr17:74689785(-) A-I      intronic chr17:74688432(-) A-I      intronic chr17:74695404(-) A-I      intronic chr17:74694916(-) A-I      intronic chr17:74703512(-) A-I      intronic chr17:74690983(-) A-I      intronic chr17:74688214(-) A-I      intronic chr17:74692354(-) A-I      intronic chr17:74686047(-) A-I      intronic chr17:74694969(-) A-I      intronic chr17:74689406(-) A-I      intronic chr17:74691060(-) A-I      intronic chr17:74690740(-) A-I      intronic chr17:74699187(-) A-I      intronic chr17:74685814(-) A-I      intronic chr17:74700704(-) A-I      intronic chr17:74694942(-) A-I      intronic chr17:74685309(-) A-I      intronic chr17:74694982(-) A-I      intronic chr17:74686574(-) A-I      intronic chr17:74700684(-) A-I      intronic chr17:74685448(-) A-I      intronic chr17:74695427(-) A-I      intronic chr17:74695326(-) A-I      intronic chr17:74685341(-) A-I      intronic chr17:74695292(-) A-I      intronic chr17:74694943(-) A-I      intronic chr17:74688599(-) A-I      intronic chr17:74689295(-) A-I      intronic chr17:74673242(-) A-I      3'UTR chr17:74685264(-) A-I      intronic chr17:74690757(-) A-I      intronic chr17:74685470(-) A-I      intronic chr17:74690828(-) A-I      intronic chr17:74685310(-) A-I      intronic chr17:74695406(-) A-I      intronic chr17:74685257(-) A-I      intronic chr17:74685923(-) A-I      intronic chr17:74695407(-) A-I      intronic chr17:74685945(-) A-I      intronic chr17:74673292(-) A-I      3'UTR chr17:74673246(-) A-I      3'UTR chr17:74695410(-) A-I      intronic chr17:74673360(-) A-I      3'UTR chr17:74692175(-) A-I      intronic chr17:74685464(-) A-I      intronic chr17:74700815(-) A-I      intronic chr17:74694901(-) A-I      intronic chr17:74698790(-) A-I      intronic chr17:74699167(-) A-I      intronic chr17:74691982(-) A-I      intronic chr17:74688281(-) A-I      intronic chr17:74673262(-) A-I      3'UTR chr17:74685337(-) A-I      intronic chr17:74685897(-) A-I      intronic chr17:74698858(-) A-I      intronic chr17:74672594(-) A-I      3'UTR chr17:74686011(-) A-I      intronic chr17:74673234(-) A-I      3'UTR chr17:74695352(-) A-I      intronic chr17:74700059(-) A-I      intronic chr17:74690779(-) A-I      intronic chr17:74688237(-) A-I      intronic chr17:74692009(-) A-I      intronic chr17:74686091(-) A-I      intronic chr17:74688338(-) A-I      intronic chr17:74685442(-) A-I      intronic chr17:74685859(-) A-I      intronic chr17:74685981(-) A-I      intronic chr17:74698407(-) A-I      intronic chr17:74673209(-) A-I      3'UTR chr17:74695405(-) A-I      intronic chr17:74691939(-) A-I      intronic chr17:74685872(-) A-I      intronic chr17:74685270(-) A-I      intronic chr17:74685348(-) A-I      intronic chr17:74695325(-) A-I      intronic chr17:74696248(-) A-I      intronic chr17:74686054(-) A-I      intronic chr17:74688396(-) A-I      intronic chr17:74690887(-) A-I      intronic chr17:74688351(-) A-I      intronic chr17:74686024(-) A-I      intronic chr17:74690914(-) A-I      intronic chr17:74689293(-) A-I      intronic chr17:74685248(-) A-I      intronic chr17:74689387(-) A-I      intronic chr17:74685363(-) A-I      intronic chr17:74686010(-) A-I      intronic chr17:74689805(-) A-I      intronic chr17:74690735(-) A-I      intronic chr17:74700675(-) A-I      intronic chr17:74685932(-) A-I      intronic chr17:74686895(-) A-I      intronic chr17:74698366(-) A-I      intronic chr17:74699501(-) A-I      intronic chr17:74686898(-) A-I      intronic chr17:74698812(-) A-I      intronic chr17:74689384(-) A-I      intronic chr17:74689463(-) A-I      intronic chr17:74685402(-) A-I      intronic chr17:74695076(-) A-I      intronic chr17:74695416(-) A-I      intronic chr17:74685944(-) A-I      intronic chr17:74679403(-) A-I      intronic chr17:74689223(-) A-I      intronic chr17:74695431(-) A-I      intronic chr17:74685304(-) A-I      intronic chr17:74692094(-) A-I      intronic chr17:74703471(-) A-I      intronic chr17:74690832(-) A-I      intronic chr17:74695455(-) A-I      intronic chr17:74689885(-) A-I      intronic chr17:74699607(-) A-I      intronic chr17:74699458(-) A-I      intronic chr17:74698507(-) A-I      intronic chr17:74688403(-) A-I      intronic chr17:74689693(-) A-I      intronic chr17:74692012(-) A-I      intronic chr17:74688433(-) A-I      intronic chr17:74685277(-) A-I      intronic chr17:74685357(-) A-I      intronic chr17:74695501(-) A-I      intronic chr17:74695034(-) A-I      intronic chr17:74696223(-) A-I      intronic chr17:74690827(-) A-I      intronic chr17:74688228(-) A-I      intronic chr17:74671903(-) A-I      3'UTR chr17:74673291(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MXRA7	chr17:74671903(-) A-I exon 3'UTR    15342557 chr17:74685248(-) A-I intron -    15342557 chr17:74685257(-) A-I intron -    15342557 chr17:74685264(-) A-I intron -    15342557 chr17:74685270(-) A-I intron -    15342557 chr17:74685277(-) A-I intron -    15342557 chr17:74685300(-) A-I intron -    15342557 chr17:74685309(-) A-I intron -    15342557 chr17:74685310(-) A-I intron -    15342557 chr17:74685348(-) A-I intron -    15342557 chr17:74685357(-) A-I intron -    15342557 chr17:74685363(-) A-I intron -    15342557 chr17:74685378(-) A-I intron -    15342557 chr17:74685402(-) A-I intron -    15342557 chr17:74685421(-) A-I intron -    15342557 chr17:74685442(-) A-I intron -    15342557 chr17:74685464(-) A-I intron -    15342557 chr17:74685470(-) A-I intron -    15342557 chr17:74685863(-) A-I intron -    15342557 chr17:74685872(-) A-I intron -    15342557 chr17:74685878(-) A-I intron -    15342557 chr17:74685897(-) A-I intron -    15342557 chr17:74685923(-) A-I intron -    15342557 chr17:74685932(-) A-I intron -    15342557 chr17:74685944(-) A-I intron -    15342557 chr17:74685945(-) A-I intron -    15342557 chr17:74685981(-) A-I intron -    15342557 chr17:74686010(-) A-I intron -    15342557 chr17:74686011(-) A-I intron -    15342557 chr17:74686024(-) A-I intron -    15342557 chr17:74686047(-) A-I intron -    15342557 chr17:74686054(-) A-I intron -    15342557 chr17:74686091(-) A-I intron -    15342557 chr17:74673246(-) A-I exon 3'UTR    21960545 chr17:74673291(-) A-I exon 3'UTR    21960545 chr17:74673292(-) A-I exon 3'UTR    21960545 chr17:74672619(-) A-I exon 3'UTR    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MXRA7	chr17:74668654-74668655(-) m6A 3'UTR       22608085 chr17:74668707-74668708(-) m6A 3'UTR       25456834//24981863//22608085 chr17:74668826-74668827(-) m6A 3'UTR       24981863//22608085 chr17:74668948-74668949(-) m6A 3'UTR       22608085 chr17:74669026-74669027(-) m6A 3'UTR       22608085 chr17:74669060-74669061(-) m6A 3'UTR       22608085 chr17:74669183-74669184(-) m6A 3'UTR       24209618//25456834//22608085 chr17:74669243-74669244(-) m6A 3'UTR       25456834//24981863//22608085 chr17:74669529-74669530(-) m6A 3'UTR       22608085 chr17:74669583-74669584(-) m6A 3'UTR       22608085 chr17:74669848-74669849(-) m6A 3'UTR       27773535 chr17:74669890-74669891(-) m6A 3'UTR       24981863//27773535 chr17:74669928-74669929(-) m6A 3'UTR       24981863//27773535 chr17:74670059-74670060(-) m6A 3'UTR       24981863//27773535 chr17:74670104-74670105(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr17:74670155-74670156(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr17:74670199-74670200(-) m6A 3'UTR       24981863//22608085 chr17:74670227-74670228(-) m6A 3'UTR       24981863//27773535//22608085 chr17:74670269-74670270(-) m6A 3'UTR       24981863//27773535//22608085 chr17:74670341-74670342(-) m6A 3'UTR       24981863//27773535 chr17:74670367-74670368(-) m6A 3'UTR       24981863//27773535 chr17:74670408-74670409(-) m6A 3'UTR       24981863 chr17:74670541-74670542(-) m6A 3'UTR       24981863 chr17:74670554-74670555(-) m6A 3'UTR       24981863 chr17:74670693-74670694(-) m6A 3'UTR       - chr17:74670808-74670809(-) m6A 3'UTR       24981863//22608085 chr17:74670827-74670828(-) m6A 3'UTR       24981863//22608085 chr17:74670834-74670835(-) m6A 3'UTR       24981863//22608085 chr17:74670925-74670926(-) m6A 3'UTR       24981863 chr17:74671026-74671027(-) m6A 3'UTR       24981863 chr17:74671109-74671110(-) m6A 3'UTR       24981863 chr17:74671144-74671145(-) m6A 3'UTR       24981863//22608085 chr17:74671150-74671151(-) m6A 3'UTR       24981863//22608085 chr17:74671171-74671172(-) m6A 3'UTR       24981863//22608085 chr17:74671230-74671231(-) m6A 3'UTR       24981863 chr17:74673204-74673205(-) m6A 3'UTR       24209618 chr17:74673668-74673669(-) m6A 3'UTR       24209618//27371828 chr17:74673739-74673740(-) m6A CDS       24209618//24981863//27773535//27371828 chr17:74673771-74673772(-) m6A CDS       24209618//24981863//27773535//27371828 chr17:74675670-74675671(-) m6A 3'UTR//intron       24209618//24981863//27773535//27371828 chr17:74676372-74676373(-) m6A 3'UTR//intron       24284625 chr17:74676443-74676444(-) m6A 3'UTR//intron       24284625 chr17:74676513-74676514(-) m6A 3'UTR//intron       24284625//22608085 chr17:74676530-74676531(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676540-74676541(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676603-74676604(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr17:74676643-74676644(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676667-74676668(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676674-74676675(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676765-74676766(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676795-74676796(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676808-74676809(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr17:74676875-74676876(-) m6A 3'UTR//intron       24284625//24981863 chr17:74681201-74681202(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//27371828 chr17:74684244-74684245(-) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536 chr17:74684357-74684358(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536 chr17:74705661-74705662(-) m6A 5'UTR//intron       24981863 chr17:74706764-74706765(-) m6A CDS       24981863 chr17:74706899-74706900(-) m6A CDS       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519e-3p	Exosome Brain tissue     23382797 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	MXRA7	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-519e-3p	Iodine Green 9956454 Drug sensitive 2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive Kahalalide F 9898671 Drug resistant CID 9604911 9604911 Drug sensitive Actinomycin X4357G methoxime 9573583 Drug sensitive Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive Venenatine 73061 Drug sensitive Redoxal 72571 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive 4-(2-Naphthylamino)phenol 7141 Drug sensitive Tolonium chloride 7083 Drug sensitive Sulbentine 67686 Drug sensitive Reactive Blue 2 656725 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive Vicenistatin 6438888 Drug sensitive Verrucarin A 6326658 Drug sensitive Deferoxamine hydrochloride 62880 Drug sensitive Cytarabine 6253 Drug sensitive Bizelesin 60794 Drug sensitive Tributyrin 6050 Drug sensitive Triethylenemelamine 5799 Drug sensitive Teclothiazide potassium 56841138 Drug sensitive (3beta)-3-((4-O-beta-D Glucopyranosyl-beta-D-xylopyranosyl)oxy)-14-hydroxy-19-oxocarda-4,20(22)-dienolide 56840951 Drug sensitive Caracemide 54747 Drug sensitive 7Z-Plakortide H 5472712 Drug sensitive Artelasticin 5471311 Drug sensitive Antineoplastic-690266 5469577 Drug sensitive 3-Deazauridine 54684286 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Betuletol 5459196 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Piritrexim isethionate 54368 Drug sensitive (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Crassin, acetate 5355441 Drug sensitive Rozex 5353923 Drug sensitive MX2 hydrochloride 5351347 Drug sensitive Dihydro-5-azacytidine 5351280 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug sensitive Vorinostat 5311 Drug sensitive Improsulfan hydrochloride 5284401 Drug sensitive Kekule 499328 Drug sensitive Pyrimethamine 4993 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant 1,4-Benzoquinone 4650 Drug sensitive Melphalan 460612 Drug sensitive Aclarubicin 451415 Drug sensitive Ossirene 451379 Drug sensitive Mycophenolic acid 446541 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Isopinnatal 44558939 Drug sensitive Iproplatin 44214 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive Aminopyrimidine-CH3 406278 Drug sensitive Mechlorethamine 4033 Drug sensitive Artelastin 399488 Drug sensitive Cbz-[Lys3]-Didemnin B 398464 Drug resistant Loratadine 3957 Drug sensitive 2,5-Bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione 394347 Drug sensitive Sjg-136 393111 Drug sensitive Leflunomide 3899 Drug sensitive beta-Lapachone 3885 Drug sensitive Lapachol 3884 Drug sensitive Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant 1,3-Diphenyl-6-((triphenylphosphoranylidene)amino)-2,4(1H,3H)-pyrimidinedione 387460 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive Stereoisomer of NSC 674066-O 384359 Drug sensitive 3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Sanguilutine pseudobase 371258 Drug sensitive 1,2-Dimethyl-phenothiazone 369387 Drug sensitive 4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive Predorine 333830 Drug sensitive Rocaglamide 331783 Drug sensitive Pinafide 327045 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive Cytosine, 1beta-D-arabinofuranosyl-N(sup 4)-stearoyl- 304673 Drug sensitive Flurocitabine 3034016 Drug sensitive P-Ara-C 282479 Drug sensitive Dichloroallyl lawsone 277767 Drug sensitive 6-Bromotoyocamycin 270861 Drug sensitive 2'-Deoxy-5-(trifluoromethyl)uridine 253083 Drug sensitive 2-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol 251928 Drug sensitive 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant 9H-Purine, 6-(o-chlorobenzylthio)-9-(2-chloroethyl)- 246231 Drug sensitive 9H-Purine, 6-(benzylthio)-9-(2-chloroethyl)- 246230 Drug sensitive Antimycin A3 245869 Drug sensitive Prumycin HCl 24197905 Drug resistant Cinerubin A hcl 24196924 Drug sensitive 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive Spongiaquinone 23424796 Drug resistant [(1S,2Z,4R,8R,9R,11R,13S)-13-Acetyloxy-1-hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] 2-methylpropanoate 23255746 Drug sensitive Amsacrine 2179 Drug sensitive Pirarubicin hydrochloride 20846247 Drug sensitive 7,8-Dihydroxyflavone 1880 Drug sensitive Sudan II 18386 Drug sensitive 4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug sensitive Azaribine 16574 Drug sensitive (2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive Methyl (3'R)-3,4',9',10-tetrahydroxy-3'-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate 137326876 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive 5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive Cysteine, S-[(4-aminocarbonyl-1H-imidazol-5-yl)azo]- 135493928 Drug sensitive Emofolin sodium 135475347 Drug sensitive 8-Azahypoxanthine 135410720 Drug sensitive Raltitrexed 135400182 Drug sensitive DTIC-Dome 135398738 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive p-Toluquinone 11122 Drug sensitive Gentian violet 11057 Drug sensitive Withajardin C 102469053 Drug sensitive (7S,9S)-7-[[(3As,4S,7aS)-1-[[(3aS,4S,7aS)-4-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-1-yl]methyl]-4-methyl-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-6-yl]oxy]-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 101713728 Drug sensitive (1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive Erigerol 101318126 Drug sensitive [(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug sensitive Tocladesine 100299 Drug sensitive (1R,2E,6R,10E,11aS,13S,14aR)-6-(2-(benzyloxy)ethyl)-1,13-dihydroxy-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one - Drug resistant 2,3-dihydro-1,2-syn-3-[phenylseleno]brefeldin a - Drug resistant 9-methoxy-5-hydroxycamptothecin - Drug resistant tp4ek - Drug resistant (Z)-N-phenyl-3-(3,4,5-trimethoxystyryl)pyridin-2-amine - Drug sensitive 1,2-naphthoquinone, 3,7-dimethyl- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive 4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug sensitive 5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug sensitive acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug sensitive b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive bersaldegenin 1,3,5-orthoacetate - Drug sensitive cis-2-hydroxymethyl-4-(5'-bromocytosin-1'-yl)-1,3-dioxolane - Drug sensitive furan-2(3h)-one, 5-(4-methylphenyl)-3,3-diphenyl- - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug sensitive phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug sensitive propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug sensitive propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive [bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive 7-propanoyltaxol - Drug sensitive Aminopterin Derivative - Drug sensitive Annamycin Liposomal - Drug sensitive antineoplastic-d665839 - Drug sensitive Camptothecin Derivative - Drug sensitive Carboxyphthalatoplatinum - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive CI-921: amsacrine derivative - Drug sensitive Indenoisoquinoline derivative - Drug sensitive insulin-methotrexate conjugate - Drug sensitive merophan - Drug sensitive mitaplatin - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive organosulfur compound - Drug sensitive trimethyl(phenylthio)stannane - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-519e-3p	Alocrest 60780 Drug interaction    RC00005536 5-Fluorouracil 3385 Drug interaction    RC00005535 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005534 Tamoxifen 2733526 Drug interaction    RC00005537

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519e-3p
Interactor2: MXRA7

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).