Basic Information:

  VIRBase ID:  

HHID00005992

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-519e-3p:  MIMAT0002829          AK3:  NM_001199855     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-519e-3p	AK3
miRBase Accession/Entrez ID	MIMAT0002829	50808
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AK3L1//AK6//AKL3L//AKL3L1//FIX

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-519e-3p	rs1320260913 chr19:53680012    T/TA rs748109530 chr19:53680008    G/A rs756692397 chr19:53679994    T/C rs762638742 chr19:53679970    CTTTCTGTTTGAAAGAAAACAAAGTGCCTCCTTTTAGAGTG/C rs778834695 chr19:53679997    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AK3	chr9:4725162(-) A-I      intronic chr9:4728485(-) A-I      intronic chr9:4728463(-) A-I      intronic chr9:4728459(-) A-I      intronic chr9:4728439(-) A-I      intronic chr9:4728414(-) A-I      intronic chr9:4725515(-) A-I      intronic chr9:4725281(-) A-I      intronic chr9:4725218(-) A-I      intronic chr9:4725188(-) A-I      intronic chr9:4721231(-) A-I      intronic chr9:4716940(-) A-I      intronic chr9:4716881(-) A-I      intronic chr9:4716809(-) A-I      intronic chr9:4738255(-) A-I      intronic chr9:4716764(-) A-I      intronic chr9:4715661(-) A-I      intronic chr9:4715036(-) A-I      intronic chr9:4733067(-) A-I      intronic chr9:4733065(-) A-I      intronic chr9:4728488(-) A-I      intronic chr9:4732976(-) A-I      intronic chr9:4732221(-) A-I      intronic chr9:4732186(-) A-I      intronic chr9:4732046(-) A-I      intronic chr9:4736058(-) A-I      intronic chr9:4732026(-) A-I      intronic chr9:4732012(-) A-I      intronic chr9:4732010(-) A-I      intronic chr9:4715510(-) A-I      intronic chr9:4715592(-) A-I      intronic chr9:4715600(-) A-I      intronic chr9:4730565(-) A-I      intronic chr9:4730553(-) A-I      intronic chr9:4736793(-) A-I      intronic chr9:4729262(-) A-I      intronic chr9:4729261(-) A-I      intronic chr9:4735570(-) A-I      intronic chr9:4729214(-) A-I      intronic chr9:4729048(-) A-I      intronic chr9:4732950(-) A-I      intronic chr9:4725139(-) A-I      intronic chr9:4724775(-) A-I      intronic chr9:4715623(-) A-I      intronic chr9:4739809(-) A-I      intronic chr9:4738242(-) A-I      intronic chr9:4725152(-) A-I      intronic chr9:4725085(-) A-I      intronic chr9:4725044(-) A-I      intronic chr9:4724741(-) A-I      intronic chr9:4724667(-) A-I      intronic chr9:4724631(-) A-I      intronic chr9:4721623(-) A-I      intronic chr9:4721603(-) A-I      intronic chr9:4721572(-) A-I      intronic chr9:4715618(-) A-I      intronic chr9:4721321(-) A-I      intronic chr9:4739812(-) A-I      intronic chr9:4738326(-) A-I      intronic chr9:4739339(-) A-I      intronic chr9:4739328(-) A-I      intronic chr9:4739301(-) A-I      intronic chr9:4739221(-) A-I      intronic chr9:4738992(-) A-I      intronic chr9:4738952(-) A-I      intronic chr9:4738951(-) A-I      intronic chr9:4738942(-) A-I      intronic chr9:4738398(-) A-I      intronic chr9:4738379(-) A-I      intronic chr9:4738369(-) A-I      intronic chr9:4738361(-) A-I      intronic chr9:4738344(-) A-I      intronic chr9:4738261(-) A-I      intronic chr9:4738238(-) A-I      intronic chr9:4737732(-) A-I      intronic chr9:4737705(-) A-I      intronic chr9:4737693(-) A-I      intronic chr9:4737516(-) A-I      intronic chr9:4736857(-) A-I      intronic chr9:4736855(-) A-I      intronic chr9:4736817(-) A-I      intronic chr9:4736799(-) A-I      intronic chr9:4736788(-) A-I      intronic chr9:4736775(-) A-I      intronic chr9:4736690(-) A-I      intronic chr9:4736077(-) A-I      intronic chr9:4735893(-) A-I      intronic chr9:4735885(-) A-I      intronic chr9:4735742(-) A-I      intronic chr9:4735741(-) A-I      intronic chr9:4735716(-) A-I      intronic chr9:4735701(-) A-I      intronic chr9:4735647(-) A-I      intronic chr9:4735178(-) A-I      intronic chr9:4735151(-) A-I      intronic chr9:4710346(-) A-I      3'UTR chr9:4710304(-) A-I      3'UTR chr9:4710316(-) A-I      3'UTR chr9:4710305(-) A-I      3'UTR chr9:4710379(-) A-I      3'UTR chr9:4710380(-) A-I      3'UTR chr9:4710801(-) A-I      3'UTR chr9:4710788(-) A-I      3'UTR chr9:4710894(-) A-I      3'UTR chr9:4725604(-) A-I      5'UTR chr9:4710675(-) A-I      3'UTR chr9:4710403(-) A-I      3'UTR chr9:4710241(-) A-I      3'UTR chr9:4725552(-) A-I      5'UTR chr9:4710255(-) A-I      3'UTR chr9:4710280(-) A-I      3'UTR chr9:4728519(-) A-I      intronic chr9:4738360(-) A-I      intronic chr9:4735515(-) A-I      intronic chr9:4737672(-) A-I      intronic chr9:4715678(-) A-I      intronic chr9:4732204(-) A-I      intronic chr9:4737529(-) A-I      intronic chr9:4735871(-) A-I      intronic chr9:4739444(-) A-I      intronic chr9:4725510(-) A-I      intronic chr9:4721340(-) A-I      intronic chr9:4737504(-) A-I      intronic chr9:4732983(-) A-I      intronic chr9:4732938(-) A-I      intronic chr9:4721158(-) A-I      intronic chr9:4729738(-) A-I      intronic chr9:4736738(-) A-I      intronic chr9:4716822(-) A-I      intronic chr9:4730503(-) A-I      intronic chr9:4738940(-) A-I      intronic chr9:4735958(-) A-I      intronic chr9:4730517(-) A-I      intronic chr9:4739016(-) A-I      intronic chr9:4735575(-) A-I      intronic chr9:4732200(-) A-I      intronic chr9:4736033(-) A-I      intronic chr9:4736052(-) A-I      intronic chr9:4725075(-) A-I      intronic chr9:4730597(-) A-I      intronic chr9:4732078(-) A-I      intronic chr9:4729703(-) A-I      intronic chr9:4725289(-) A-I      intronic chr9:4721185(-) A-I      intronic chr9:4721303(-) A-I      intronic chr9:4729149(-) A-I      intronic chr9:4729213(-) A-I      intronic chr9:4728379(-) A-I      intronic chr9:4736774(-) A-I      intronic chr9:4721255(-) A-I      intronic chr9:4728778(-) A-I      intronic chr9:4729589(-) A-I      intronic chr9:4739345(-) A-I      intronic chr9:4716831(-) A-I      intronic chr9:4715103(-) A-I      intronic chr9:4715555(-) A-I      intronic chr9:4715136(-) A-I      intronic chr9:4729148(-) A-I      intronic chr9:4739848(-) A-I      intronic chr9:4729252(-) A-I      intronic chr9:4729765(-) A-I      intronic chr9:4714974(-) A-I      intronic chr9:4738400(-) A-I      intronic chr9:4739801(-) A-I      intronic chr9:4736905(-) A-I      intronic chr9:4732071(-) A-I      intronic chr9:4739845(-) A-I      intronic chr9:4729139(-) A-I      intronic chr9:4732943(-) A-I      intronic chr9:4725206(-) A-I      intronic chr9:4729283(-) A-I      intronic chr9:4728509(-) A-I      intronic chr9:4737535(-) A-I      intronic chr9:4737636(-) A-I      intronic chr9:4729705(-) A-I      intronic chr9:4737656(-) A-I      intronic chr9:4739473(-) A-I      intronic chr9:4738946(-) A-I      intronic chr9:4715617(-) A-I      intronic chr9:4738982(-) A-I      intronic chr9:4737592(-) A-I      intronic chr9:4729613(-) A-I      intronic chr9:4721281(-) A-I      intronic chr9:4735598(-) A-I      intronic chr9:4728408(-) A-I      intronic chr9:4732052(-) A-I      intronic chr9:4738826(-) A-I      intronic chr9:4735131(-) A-I      intronic chr9:4735897(-) A-I      intronic chr9:4730546(-) A-I      intronic chr9:4715502(-) A-I      intronic chr9:4728495(-) A-I      intronic chr9:4738403(-) A-I      intronic chr9:4732961(-) A-I      intronic chr9:4736068(-) A-I      intronic chr9:4715670(-) A-I      intronic chr9:4729078(-) A-I      intronic chr9:4733048(-) A-I      intronic chr9:4710729(-) A-I      3'UTR chr9:4710243(-) A-I      3'UTR chr9:4710674(-) A-I      3'UTR chr9:4710802(-) A-I      3'UTR chr9:4710906(-) A-I      3'UTR chr9:4710823(-) A-I      3'UTR chr9:4710792(-) A-I      3'UTR chr9:4710902(-) A-I      3'UTR chr9:4725534(-) A-I      5'UTR chr9:4710683(-) A-I      3'UTR chr9:4725539(-) A-I      5'UTR chr9:4710828(-) A-I      3'UTR chr9:4710319(-) A-I      3'UTR chr9:4710815(-) A-I      3'UTR chr9:4725135(-) A-I      intronic chr9:4729591(-) A-I      intronic chr9:4735949(-) A-I      intronic chr9:4736929(-) A-I      intronic chr9:4728314(-) A-I      intronic chr9:4733122(-) A-I      intronic chr9:4735870(-) A-I      intronic chr9:4733052(-) A-I      intronic chr9:4739844(-) A-I      intronic chr9:4735203(-) A-I      intronic chr9:4730479(-) A-I      intronic chr9:4729183(-) A-I      intronic chr9:4715535(-) A-I      intronic chr9:4739750(-) A-I      intronic chr9:4729809(-) A-I      intronic chr9:4737552(-) A-I      intronic chr9:4730541(-) A-I      intronic chr9:4738304(-) A-I      intronic chr9:4730516(-) A-I      intronic chr9:4730534(-) A-I      intronic chr9:4724684(-) A-I      intronic chr9:4732182(-) A-I      intronic chr9:4739388(-) A-I      intronic chr9:4733076(-) A-I      intronic chr9:4738928(-) A-I      intronic chr9:4730521(-) A-I      intronic chr9:4732018(-) A-I      intronic chr9:4735546(-) A-I      intronic chr9:4738880(-) A-I      intronic chr9:4715574(-) A-I      intronic chr9:4735177(-) A-I      intronic chr9:4736826(-) A-I      intronic chr9:4738887(-) A-I      intronic chr9:4729778(-) A-I      intronic chr9:4724613(-) A-I      intronic chr9:4735952(-) A-I      intronic chr9:4725126(-) A-I      intronic chr9:4730562(-) A-I      intronic chr9:4724696(-) A-I      intronic chr9:4735670(-) A-I      intronic chr9:4729247(-) A-I      intronic chr9:4733009(-) A-I      intronic chr9:4732114(-) A-I      intronic chr9:4739822(-) A-I      intronic chr9:4729434(-) A-I      intronic chr9:4739397(-) A-I      intronic chr9:4732199(-) A-I      intronic chr9:4738268(-) A-I      intronic chr9:4737637(-) A-I      intronic chr9:4729590(-) A-I      intronic chr9:4735642(-) A-I      intronic chr9:4739466(-) A-I      intronic chr9:4735545(-) A-I      intronic chr9:4725290(-) A-I      intronic chr9:4735576(-) A-I      intronic chr9:4715523(-) A-I      intronic chr9:4736071(-) A-I      intronic chr9:4732230(-) A-I      intronic chr9:4738869(-) A-I      intronic chr9:4729203(-) A-I      intronic chr9:4736950(-) A-I      intronic chr9:4728422(-) A-I      intronic chr9:4738874(-) A-I      intronic chr9:4738438(-) A-I      intronic chr9:4733086(-) A-I      intronic chr9:4739355(-) A-I      intronic chr9:4728405(-) A-I      intronic chr9:4739782(-) A-I      intronic chr9:4724679(-) A-I      intronic chr9:4729282(-) A-I      intronic chr9:4738955(-) A-I      intronic chr9:4735184(-) A-I      intronic chr9:4738977(-) A-I      intronic chr9:4735748(-) A-I      intronic chr9:4724657(-) A-I      intronic chr9:4735682(-) A-I      intronic chr9:4733121(-) A-I      intronic chr9:4729727(-) A-I      intronic chr9:4739045(-) A-I      intronic chr9:4735932(-) A-I      intronic chr9:4735715(-) A-I      intronic chr9:4735672(-) A-I      intronic chr9:4732022(-) A-I      intronic chr9:4738857(-) A-I      intronic chr9:4728449(-) A-I      intronic chr9:4729715(-) A-I      intronic chr9:4738893(-) A-I      intronic chr9:4737632(-) A-I      intronic chr9:4725051(-) A-I      intronic chr9:4738439(-) A-I      intronic chr9:4715422(-) A-I      intronic chr9:4739061(-) A-I      intronic chr9:4739335(-) A-I      intronic chr9:4721580(-) A-I      intronic chr9:4732238(-) A-I      intronic chr9:4724773(-) A-I      intronic chr9:4721556(-) A-I      intronic chr9:4722831(-) A-I      intronic chr9:4729223(-) A-I      intronic chr9:4736848(-) A-I      intronic chr9:4729175(-) A-I      intronic chr9:4721587(-) A-I      intronic chr9:4735540(-) A-I      intronic chr9:4739389(-) A-I      intronic chr9:4721284(-) A-I      intronic chr9:4728327(-) A-I      intronic chr9:4735213(-) A-I      intronic chr9:4725121(-) A-I      intronic chr9:4738345(-) A-I      intronic chr9:4724776(-) A-I      intronic chr9:4739461(-) A-I      intronic chr9:4735927(-) A-I      intronic chr9:4739688(-) A-I      intronic chr9:4737602(-) A-I      intronic chr9:4725161(-) A-I      intronic chr9:4737582(-) A-I      intronic chr9:4715505(-) A-I      intronic chr9:4728447(-) A-I      intronic chr9:4739783(-) A-I      intronic chr9:4739351(-) A-I      intronic chr9:4736896(-) A-I      intronic chr9:4736951(-) A-I      intronic chr9:4738385(-) A-I      intronic chr9:4729181(-) A-I      intronic chr9:4736741(-) A-I      intronic chr9:4735159(-) A-I      intronic chr9:4729578(-) A-I      intronic chr9:4739387(-) A-I      intronic chr9:4736879(-) A-I      intronic chr9:4728353(-) A-I      intronic chr9:4733100(-) A-I      intronic chr9:4729217(-) A-I      intronic chr9:4728752(-) A-I      intronic chr9:4730520(-) A-I      intronic chr9:4730596(-) A-I      intronic chr9:4738233(-) A-I      intronic chr9:4728431(-) A-I      intronic chr9:4716879(-) A-I      intronic chr9:4739040(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AK3	chr9:4729148(-) A-I intron -    22327324 chr9:4729738(-) A-I intron -    22327324 chr9:4730517(-) A-I intron -    22327324 chr9:4730520(-) A-I intron -    22327324 chr9:4730596(-) A-I intron -    22327324 chr9:4735159(-) A-I intron -    22327324 chr9:4735184(-) A-I intron -    22327324 chr9:4736905(-) A-I intron -    22327324 chr9:4736928(-) A-I intron -    21960545   //22327324 chr9:4736973(-) A-I intron -    22327324 chr9:4739345(-) A-I intron -    22327324 chr9:4710815(-) A-I exon 3'UTR    22327324 chr9:4729715(-) A-I intron -    21960545 chr9:4729718(-) A-I intron -    21960545 chr9:4729719(-) A-I intron -    21960545 chr9:4729590(-) A-I intron -    21960545 chr9:4729591(-) A-I intron -    21960545 chr9:4736842(-) A-I intron -    21960545 chr9:4736929(-) A-I intron -    21960545 chr9:4738140(-) A-G intron -    22484847 chr9:4710319(-) A-G exon 3'UTR    22484847 chr9:4710815(-) A-G exon 3'UTR    22484847 chr9:4710877(-) A-G exon 3'UTR    22484847 chr9:4715527(-) A-G intron -    22484847 chr9:4715669(-) A-G intron -    22484847 chr9:4724657(-) A-G intron -    22484847 chr9:4724684(-) A-G intron -    22484847 chr9:4724773(-) A-G intron -    22484847 chr9:4725120(-) A-G intron -    22484847 chr9:4725121(-) A-G intron -    22484847 chr9:4725161(-) A-G intron -    22484847 chr9:4728326(-) A-G intron -    22484847 chr9:4728447(-) A-G intron -    22484847 chr9:4728449(-) A-G intron -    22484847 chr9:4728495(-) A-G intron -    22484847 chr9:4728557(-) A-G intron -    22484847 chr9:4729148(-) A-G intron -    22484847 chr9:4729229(-) A-G intron -    22484847 chr9:4729590(-) A-G intron -    22484847 chr9:4729591(-) A-G intron -    22484847 chr9:4729623(-) A-G intron -    22484847 chr9:4729718(-) A-G intron -    22484847 chr9:4729719(-) A-G intron -    22484847 chr9:4729732(-) A-G intron -    22484847 chr9:4729738(-) A-G intron -    22484847 chr9:4730479(-) A-G intron -    22484847 chr9:4730517(-) A-G intron -    22484847 chr9:4730521(-) A-G intron -    22484847 chr9:4730562(-) A-G intron -    22484847 chr9:4730596(-) A-G intron -    22484847 chr9:4732078(-) A-G intron -    22484847 chr9:4732182(-) A-G intron -    22484847 chr9:4732943(-) A-G intron -    22484847 chr9:4732961(-) A-G intron -    22484847 chr9:4732983(-) A-G intron -    22484847 chr9:4733122(-) A-G intron -    22484847 chr9:4735150(-) A-G intron -    22484847 chr9:4735159(-) A-G intron -    22484847 chr9:4735184(-) A-G intron -    22484847 chr9:4735715(-) A-G intron -    22484847 chr9:4736033(-) A-G intron -    22484847 chr9:4736816(-) A-G intron -    22484847 chr9:4736826(-) A-G intron -    22484847 chr9:4736894(-) A-G intron -    22484847 chr9:4736905(-) A-G intron -    22484847 chr9:4736928(-) A-G intron -    22484847 chr9:4736973(-) A-G intron -    22484847 chr9:4737535(-) A-G intron -    22484847 chr9:4737672(-) A-G intron -    22484847 chr9:4737714(-) A-G intron -    22484847 chr9:4738262(-) A-G intron -    22484847 chr9:4739335(-) A-G intron -    22484847 chr9:4739345(-) A-G intron -    22484847 chr9:4739364(-) A-G intron -    22484847 chr9:4739387(-) A-G intron -    22484847 chr9:4739458(-) A-G intron -    22484847 chr9:4739473(-) A-G intron -    22484847 chr9:4739688(-) A-G intron -    22484847 chr9:4739767(-) A-G intron -    22484847 chr9:4739807(-) A-G intron -    22484847 chr9:4739844(-) A-G intron -    22484847 chr9:4739845(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AK3	chr9:4711794-4711795(-) m6A 3'UTR       27773535 chr9:4711890-4711891(-) m6A 3'UTR       27773535 chr9:4711934-4711935(-) m6A 3'UTR       24981863//27773535 chr9:4712044-4712045(-) m6A 3'UTR       24981863//27773535 chr9:4712469-4712470(-) m6A 3'UTR       22608085 chr9:4712523-4712524(-) m6A 3'UTR       24981863//22608085 chr9:4712533-4712534(-) m6A 3'UTR       24981863//22608085 chr9:4712552-4712553(-) m6A 3'UTR       24981863//22608085 chr9:4712897-4712898(-) m6A 3'UTR       24981863//22608085 chr9:4712936-4712937(-) m6A 3'UTR       24981863//22608085 chr9:4713019-4713020(-) m6A CDS       22608085 chr9:4713058-4713059(-) m6A CDS       22608085 chr9:4740956-4740957(-) m6A CDS//intron       27773536 chr9:4740968-4740969(-) m6A CDS//intron       27773536 chr9:4741206-4741207(-) m6A 5'UTR//intron       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-519e-3p	Exosome Brain tissue     23382797 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	AK3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-519e-3p	Iodine Green 9956454 Drug sensitive 2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive Kahalalide F 9898671 Drug resistant CID 9604911 9604911 Drug sensitive Actinomycin X4357G methoxime 9573583 Drug sensitive Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive Venenatine 73061 Drug sensitive Redoxal 72571 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive 4-(2-Naphthylamino)phenol 7141 Drug sensitive Tolonium chloride 7083 Drug sensitive Sulbentine 67686 Drug sensitive Reactive Blue 2 656725 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive Vicenistatin 6438888 Drug sensitive Verrucarin A 6326658 Drug sensitive Deferoxamine hydrochloride 62880 Drug sensitive Cytarabine 6253 Drug sensitive Bizelesin 60794 Drug sensitive Tributyrin 6050 Drug sensitive Triethylenemelamine 5799 Drug sensitive Teclothiazide potassium 56841138 Drug sensitive (3beta)-3-((4-O-beta-D Glucopyranosyl-beta-D-xylopyranosyl)oxy)-14-hydroxy-19-oxocarda-4,20(22)-dienolide 56840951 Drug sensitive Caracemide 54747 Drug sensitive 7Z-Plakortide H 5472712 Drug sensitive Artelasticin 5471311 Drug sensitive Antineoplastic-690266 5469577 Drug sensitive 3-Deazauridine 54684286 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive Herveline O 5459269 Drug sensitive Betuletol 5459196 Drug sensitive Cuspidatin C 5459164 Drug sensitive Thiram 5455 Drug sensitive Piritrexim isethionate 54368 Drug sensitive (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Crassin, acetate 5355441 Drug sensitive Rozex 5353923 Drug sensitive MX2 hydrochloride 5351347 Drug sensitive Dihydro-5-azacytidine 5351280 Drug sensitive 7-(3-Methoxyphenyl)-N-(pyridin-4-ylmethylideneamino)-5H-pyrrolo[3,2-d]pyrimidin-4-amine 53239944 Drug sensitive Vorinostat 5311 Drug sensitive Improsulfan hydrochloride 5284401 Drug sensitive Kekule 499328 Drug sensitive Pyrimethamine 4993 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant 1,4-Benzoquinone 4650 Drug sensitive Melphalan 460612 Drug sensitive Aclarubicin 451415 Drug sensitive Ossirene 451379 Drug sensitive Mycophenolic acid 446541 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Isopinnatal 44558939 Drug sensitive Iproplatin 44214 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive Aminopyrimidine-CH3 406278 Drug sensitive Mechlorethamine 4033 Drug sensitive Artelastin 399488 Drug sensitive Cbz-[Lys3]-Didemnin B 398464 Drug resistant Loratadine 3957 Drug sensitive 2,5-Bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione 394347 Drug sensitive Sjg-136 393111 Drug sensitive Leflunomide 3899 Drug sensitive beta-Lapachone 3885 Drug sensitive Lapachol 3884 Drug sensitive Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant 1,3-Diphenyl-6-((triphenylphosphoranylidene)amino)-2,4(1H,3H)-pyrimidinedione 387460 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive Stereoisomer of NSC 674066-O 384359 Drug sensitive 3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Sanguilutine pseudobase 371258 Drug sensitive 1,2-Dimethyl-phenothiazone 369387 Drug sensitive 4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive Predorine 333830 Drug sensitive Rocaglamide 331783 Drug sensitive Pinafide 327045 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive Cytosine, 1beta-D-arabinofuranosyl-N(sup 4)-stearoyl- 304673 Drug sensitive Flurocitabine 3034016 Drug sensitive P-Ara-C 282479 Drug sensitive Dichloroallyl lawsone 277767 Drug sensitive 6-Bromotoyocamycin 270861 Drug sensitive 2'-Deoxy-5-(trifluoromethyl)uridine 253083 Drug sensitive 2-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol 251928 Drug sensitive 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant 9H-Purine, 6-(o-chlorobenzylthio)-9-(2-chloroethyl)- 246231 Drug sensitive 9H-Purine, 6-(benzylthio)-9-(2-chloroethyl)- 246230 Drug sensitive Antimycin A3 245869 Drug sensitive Prumycin HCl 24197905 Drug resistant Cinerubin A hcl 24196924 Drug sensitive 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive Spongiaquinone 23424796 Drug resistant [(1S,2Z,4R,8R,9R,11R,13S)-13-Acetyloxy-1-hydroxy-2,11-dimethyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] 2-methylpropanoate 23255746 Drug sensitive Amsacrine 2179 Drug sensitive Pirarubicin hydrochloride 20846247 Drug sensitive 7,8-Dihydroxyflavone 1880 Drug sensitive Sudan II 18386 Drug sensitive 4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug sensitive Azaribine 16574 Drug sensitive (2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive Methyl (3'R)-3,4',9',10-tetrahydroxy-3'-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate 137326876 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive 5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive Cysteine, S-[(4-aminocarbonyl-1H-imidazol-5-yl)azo]- 135493928 Drug sensitive Emofolin sodium 135475347 Drug sensitive 8-Azahypoxanthine 135410720 Drug sensitive Raltitrexed 135400182 Drug sensitive DTIC-Dome 135398738 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive p-Toluquinone 11122 Drug sensitive Gentian violet 11057 Drug sensitive Withajardin C 102469053 Drug sensitive (7S,9S)-7-[[(3As,4S,7aS)-1-[[(3aS,4S,7aS)-4-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-1-yl]methyl]-4-methyl-2,3a,4,6,7,7a-hexahydropyrano[4,3-d][1,3]oxazol-6-yl]oxy]-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 101713728 Drug sensitive (1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive Erigerol 101318126 Drug sensitive [(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug sensitive Tocladesine 100299 Drug sensitive (1R,2E,6R,10E,11aS,13S,14aR)-6-(2-(benzyloxy)ethyl)-1,13-dihydroxy-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one - Drug resistant 2,3-dihydro-1,2-syn-3-[phenylseleno]brefeldin a - Drug resistant 9-methoxy-5-hydroxycamptothecin - Drug resistant tp4ek - Drug resistant (Z)-N-phenyl-3-(3,4,5-trimethoxystyryl)pyridin-2-amine - Drug sensitive 1,2-naphthoquinone, 3,7-dimethyl- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive 4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive 4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive 4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug sensitive 5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 5-methoxy- - Drug sensitive acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug sensitive b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive bersaldegenin 1,3,5-orthoacetate - Drug sensitive cis-2-hydroxymethyl-4-(5'-bromocytosin-1'-yl)-1,3-dioxolane - Drug sensitive furan-2(3h)-one, 5-(4-methylphenyl)-3,3-diphenyl- - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug sensitive phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug sensitive propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug sensitive propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive [bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive 7-propanoyltaxol - Drug sensitive Aminopterin Derivative - Drug sensitive Annamycin Liposomal - Drug sensitive antineoplastic-d665839 - Drug sensitive Camptothecin Derivative - Drug sensitive Carboxyphthalatoplatinum - Drug sensitive chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive CI-921: amsacrine derivative - Drug sensitive Indenoisoquinoline derivative - Drug sensitive insulin-methotrexate conjugate - Drug sensitive merophan - Drug sensitive mitaplatin - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive organosulfur compound - Drug sensitive trimethyl(phenylthio)stannane - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-519e-3p	Alocrest 60780 Drug interaction    RC00005536 5-Fluorouracil 3385 Drug interaction    RC00005535 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005534 Tamoxifen 2733526 Drug interaction    RC00005537

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-519e-3p
Interactor2: AK3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).