Basic Information:

  VIRBase ID:  

HHID00005517

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PHOSPHO2-KLHL23:  NR_144936     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PHOSPHO2-KLHL23
miRBase Accession/Entrez ID	MIMAT0000458	100526832
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PHOSPHO2-KLHL23	chr2:170559819(+) A-I intron -    15258596 chr2:170559835(+) A-I intron -    15258596 chr2:170559843(+) A-I intron -    15258596 chr2:170606427(+) A-I exon 3'UTR    15342557 chr2:170606467(+) A-I exon 3'UTR    15342557 chr2:170606527(+) A-I exon 3'UTR    15342557 chr2:170606588(+) A-I exon 3'UTR    15342557 chr2:170606724(+) A-I exon 3'UTR    15342557 chr2:170607750(+) A-I exon 3'UTR    15342557 chr2:170566019(+) A-I intron -    22327324 chr2:170558876(+) A-I intron -    21960545 chr2:170559002(+) A-I intron -    21960545 chr2:170559738(+) A-I intron -    21960545 chr2:170558928(+) A-I intron -    21960545 chr2:170565983(+) A-I intron -    21960545 chr2:170560885(+) A-G intron -    22484847 chr2:170562760(+) A-G intron -    22484847 chr2:170558876(+) A-G intron -    22484847 chr2:170558963(+) A-G intron -    22484847 chr2:170558969(+) A-G intron -    22484847 chr2:170558976(+) A-G intron -    22484847 chr2:170559003(+) A-G intron -    22484847 chr2:170559843(+) A-G intron -    22484847 chr2:170559852(+) A-G intron -    22484847 chr2:170559858(+) A-G intron -    22484847 chr2:170562041(+) A-G intron -    22484847 chr2:170563216(+) A-G intron -    22484847 chr2:170563553(+) A-G intron -    22484847 chr2:170566019(+) A-G intron -    22484847 chr2:170566020(+) A-G intron -    22484847 chr2:170566081(+) A-G intron -    22484847 chr2:170566097(+) A-G intron -    22484847 chr2:170566200(+) A-G intron -    22484847 chr2:170566217(+) A-G intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PHOSPHO2-KLHL23

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).