Basic Information:

  VIRBase ID:  

HHID00005488

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          C18orf32:  NM_001199346     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	C18orf32
miRBase Accession/Entrez ID	MIMAT0000458	497661
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C18orf32	chr18:47012219(-) A-I      intronic chr18:47012202(-) A-I      intronic chr18:47008917(-) A-I      intronic chr18:47008905(-) A-I      intronic chr18:47008909(-) A-I      intronic chr18:47011800(-) A-I      intronic chr18:47008969(-) A-I      intronic chr18:47011802(-) A-I      intronic chr18:47009071(-) A-I      intronic chr18:47009088(-) A-I      intronic chr18:47009229(-) A-I      intronic chr18:47011842(-) A-I      intronic chr18:47009385(-) A-I      intronic chr18:47008864(-) A-I      intronic chr18:47009313(-) A-I      intronic chr18:47010455(-) A-I      intronic chr18:47010387(-) A-I      intronic chr18:47009342(-) A-I      intronic chr18:47012116(-) A-I      intronic chr18:47009265(-) A-I      intronic chr18:47008931(-) A-I      intronic chr18:47011287(-) A-I      intronic chr18:47009351(-) A-I      intronic chr18:47012103(-) A-I      intronic chr18:47009333(-) A-I      intronic chr18:47010308(-) A-I      intronic chr18:47008997(-) A-I      intronic chr18:47012264(-) A-I      intronic chr18:47012195(-) A-I      intronic chr18:47011389(-) A-I      intronic chr18:47010861(-) A-I      intronic chr18:47009089(-) A-I      intronic chr18:47012015(-) A-I      intronic chr18:47009455(-) A-I      intronic chr18:47009450(-) A-I      intronic chr18:47009345(-) A-I      intronic chr18:47012265(-) A-I      intronic chr18:47009372(-) A-I      intronic chr18:47008836(-) A-I      intronic chr18:47012180(-) A-I      intronic chr18:47011752(-) A-I      intronic chr18:47011290(-) A-I      intronic chr18:47008842(-) A-I      intronic chr18:47012080(-) A-I      intronic chr18:47008934(-) A-I      intronic chr18:47009297(-) A-I      intronic chr18:47009433(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C18orf32	chr18:47008621-47008622(-) m6A 3'UTR       24981863//22608085 chr18:47008675-47008676(-) m6A 3'UTR       24284625//24981863//28052920//22608085 chr18:47008696-47008697(-) m6A 3'UTR       24284625//24981863//28052920//22608085 chr18:47008718-47008719(-) m6A CDS       24284625//24981863//28052920//22608085 chr18:47008747-47008748(-) m6A CDS       24284625//24981863//28052920//22608085 chr18:47008772-47008773(-) m6A CDS       24284625//24981863//22608085 chr18:47009960-47009961(-) m6A CDS       24284625//24981863//22608085 chr18:47009975-47009976(-) m6A CDS       24284625//24981863//22608085 chr18:47013605-47013606(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	C18orf32	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: C18orf32

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).