Basic Information:

  VIRBase ID:  

HHID00005483

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PALM2AKAP2:  NM_007203     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PALM2AKAP2
miRBase Accession/Entrez ID	MIMAT0000458	445815
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AKAP-2//AKAP-KL//AKAP2//AKAPKL//MISP2//PALM2//PALM2-AKAP2//PRKA2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PALM2AKAP2	chr9:112781507(+) A-I      intronic chr9:112801043(+) A-I      intronic chr9:112781465(+) A-I      intronic chr9:112801054(+) A-I      intronic chr9:112801100(+) A-I      intronic chr9:112801101(+) A-I      intronic chr9:112801035(+) A-I      intronic chr9:112788460(+) A-I      intronic chr9:112801106(+) A-I      intronic chr9:112781658(+) A-I      intronic chr9:112801444(+) A-I      intronic chr9:112781610(+) A-I      intronic chr9:112780071(+) A-I      intronic chr9:112780115(+) A-I      intronic chr9:112780137(+) A-I      intronic chr9:112801110(+) A-I      intronic chr9:112781670(+) A-I      intronic chr9:112801127(+) A-I      intronic chr9:112804583(+) A-I      intronic chr9:112781470(+) A-I      intronic chr9:112781480(+) A-I      intronic chr9:112801133(+) A-I      intronic chr9:112801033(+) A-I      intronic chr9:112801032(+) A-I      intronic chr9:112801018(+) A-I      intronic chr9:112801470(+) A-I      intronic chr9:112800478(+) A-I      intronic chr9:112800370(+) A-I      intronic chr9:112781499(+) A-I      intronic chr9:112781506(+) A-I      intronic chr9:112800362(+) A-I      intronic chr9:112800345(+) A-I      intronic chr9:112795131(+) A-I      intronic chr9:112795111(+) A-I      intronic chr9:112789293(+) A-I      intronic chr9:112789275(+) A-I      intronic chr9:112789264(+) A-I      intronic chr9:112789248(+) A-I      intronic chr9:112785672(+) A-I      intronic chr9:112785651(+) A-I      intronic chr9:112780242(+) A-I      intronic chr9:112780217(+) A-I      intronic chr9:112780111(+) A-I      intronic chr9:112780108(+) A-I      intronic chr9:112759371(+) A-I      intronic chr9:112718129(+) A-I      intronic chr9:112781676(+) A-I      intronic chr9:112793411(+) A-I      intronic chr9:112809022(+) A-I      intronic chr9:112785675(+) A-I      intronic chr9:112793477(+) A-I      intronic chr9:112794581(+) A-I      intronic chr9:112746025(+) A-I      intronic chr9:112781343(+) A-I      intronic chr9:112800964(+) A-I      intronic chr9:112780740(+) A-I      intronic chr9:112786025(+) A-I      intronic chr9:112781357(+) A-I      intronic chr9:112745986(+) A-I      intronic chr9:112781361(+) A-I      intronic chr9:112781452(+) A-I      intronic chr9:112785723(+) A-I      intronic chr9:112746700(+) A-I      intronic chr9:112780704(+) A-I      intronic chr9:112786117(+) A-I      intronic chr9:112800359(+) A-I      intronic chr9:112781334(+) A-I      intronic chr9:112799537(+) A-I      intronic chr9:112781426(+) A-I      intronic chr9:112795136(+) A-I      intronic chr9:112786138(+) A-I      intronic chr9:112799681(+) A-I      intronic chr9:112798379(+) A-I      intronic chr9:112746030(+) A-I      intronic chr9:112733921(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	PALM2AKAP2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PALM2AKAP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).