Detail Information

Basic Information:


  VIRBase ID:  

HHID00005461

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           VGLL3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p VGLL3
miRBase
Accession/Entrez ID		 MIMAT0000458 389136
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - VGL-3//VGL3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VGLL3
chr3:87023442(-) A-I      intronic
chr3:87023379(-) A-I      intronic
chr3:87023439(-) A-I      intronic
chr3:87023472(-) A-I      intronic
chr3:87023482(-) A-I      intronic
chr3:87023392(-) A-I      intronic
chr3:87023457(-) A-I      intronic
chr3:87004568(-) A-I      intronic
chr3:87023432(-) A-I      intronic
chr3:87023428(-) A-I      intronic
chr3:87023423(-) A-I      intronic
chr3:87023364(-) A-I      intronic
chr3:87023446(-) A-I      intronic
chr3:87023496(-) A-I      intronic
chr3:87023365(-) A-I      intronic
chr3:87023396(-) A-I      intronic
chr3:87023373(-) A-I      intronic
chr3:86988583(-) A-I      3'UTR
chr3:86988609(-) A-I      3'UTR
chr3:87023477(-) A-I      intronic
chr3:86993598(-) A-I      3'UTR
chr3:87011911(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VGLL3
chr3:86987686-86987687(-) m6A 3'UTR       24981863//22575960//22608085
chr3:86987724-86987725(-) m6A 3'UTR       24981863//22575960//22608085
chr3:86987785-86987786(-) m6A 3'UTR       22575960//22608085
chr3:86987797-86987798(-) m6A 3'UTR       22575960//22608085
chr3:86995998-86995999(-) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085
chr3:86996059-86996060(-) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085
chr3:86996083-86996084(-) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085
chr3:86996171-86996172(-) m6A 3'UTR       24209618//24981863//26404942//22575960//22608085
chr3:86996201-86996202(-) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr3:87017768-87017769(-) m6A CDS       24209618//24981863//22575960
chr3:87017775-87017776(-) m6A CDS       24209618//24981863//22575960
chr3:87017827-87017828(-) m6A CDS       24209618//24981863//22575960
chr3:87017832-87017833(-) m6A CDS       24209618//24981863//22575960
chr3:87018093-87018094(-) m6A CDS       24284625//24209618//24981863//22575960
chr3:87018109-87018110(-) m6A CDS       24284625//24209618//25456834//24981863//22575960
chr3:87018154-87018155(-) m6A CDS       24209618//24981863//22575960
chr3:87018222-87018223(-) m6A CDS       24209618//22575960
chr3:87027766-87027767(-) m6A CDS       24209618//25456834//24981863//22575960
chr3:87027788-87027789(-) m6A CDS       24209618//25456834//24981863//22575960
chr3:87027851-87027852(-) m6A CDS//intron       25456834//24981863//22575960
chr3:87027892-87027893(-) m6A CDS//intron       25456834
chr3:87027920-87027921(-) m6A CDS//intron       22575960
chr3:87040024-87040025(-) m6A 5'UTR       22575960
chr3:87040126-87040127(-) m6A 5'UTR       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
VGLL3
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: VGLL3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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