Detail Information

Basic Information:


  VIRBase ID:  

HHID00005454

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           ZC3H6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p ZC3H6
miRBase
Accession/Entrez ID		 MIMAT0000458 376940
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ZC3HDC6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZC3H6
chr2:113077730(+) A-I      intronic
chr2:113077566(+) A-I      intronic
chr2:113077540(+) A-I      intronic
chr2:113077695(+) A-I      intronic
chr2:113043337(+) A-I      intronic
chr2:113096626(+) A-I      3'UTR
chr2:113096598(+) A-I      3'UTR
chr2:113043083(+) A-I      intronic
chr2:113096586(+) A-I      3'UTR
chr2:113043075(+) A-I      intronic
chr2:113043063(+) A-I      intronic
chr2:113043035(+) A-I      intronic
chr2:113043361(+) A-I      intronic
chr2:113043342(+) A-I      intronic
chr2:113066535(+) A-I      intronic
chr2:113066518(+) A-I      intronic
chr2:113066447(+) A-I      intronic
chr2:113045364(+) A-I      intronic
chr2:113043418(+) A-I      intronic
chr2:113043373(+) A-I      intronic
chr2:113043367(+) A-I      intronic
chr2:113043352(+) A-I      intronic
chr2:113043351(+) A-I      intronic
chr2:113043132(+) A-I      intronic
chr2:113043038(+) A-I      intronic
chr2:113042973(+) A-I      intronic
chr2:113036125(+) A-I      intronic
chr2:113045386(+) A-I      intronic
chr2:113084294(+) A-I      intronic
chr2:113084293(+) A-I      intronic
chr2:113077205(+) A-I      intronic
chr2:113077112(+) A-I      intronic
chr2:113077013(+) A-I      intronic
chr2:113070362(+) A-I      intronic
chr2:113086293(+) A-I      intronic
chr2:113085560(+) A-I      intronic
chr2:113085531(+) A-I      intronic
chr2:113066514(+) A-I      intronic
chr2:113055536(+) A-I      intronic
chr2:113056600(+) A-I      intronic
chr2:113043051(+) A-I      intronic
chr2:113066531(+) A-I      intronic
chr2:113055545(+) A-I      intronic
chr2:113045253(+) A-I      intronic
chr2:113070184(+) A-I      intronic
chr2:113066192(+) A-I      intronic
chr2:113066054(+) A-I      intronic
chr2:113070237(+) A-I      intronic
chr2:113043163(+) A-I      intronic
chr2:113076801(+) A-I      intronic
chr2:113073266(+) A-I      intronic
chr2:113096654(+) A-I      3'UTR
chr2:113095314(+) A-I      3'UTR
chr2:113095779(+) A-I      3'UTR
chr2:113036096(+) A-I      intronic
chr2:113076867(+) A-I      intronic
chr2:113077058(+) A-I      intronic
chr2:113043463(+) A-I      intronic
chr2:113076990(+) A-I      intronic
chr2:113055572(+) A-I      intronic
chr2:113087837(+) A-I      intronic
chr2:113043209(+) A-I      intronic
chr2:113068851(+) A-I      intronic
chr2:113076989(+) A-I      intronic
chr2:113043014(+) A-I      intronic
chr2:113066209(+) A-I      intronic
chr2:113076810(+) A-I      intronic
chr2:113066127(+) A-I      intronic
chr2:113070168(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZC3H6
chr2:113045253(+) A-G intron -    22484847
chr2:113047339(+) T-G intron -    22484847
chr2:113047340(+) G-T intron -    22484847
chr2:113047341(+) A-T intron -    22484847
chr2:113076810(+) A-G intron -    22484847
chr2:113082887(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZC3H6
chr2:113033311-113033312(+) m6A 5'UTR       22608085
chr2:113033535-113033536(+) m6A 5'UTR       27773536//22608085
chr2:113033569-113033570(+) m6A 5'UTR       24981863//27773535//27773536//22608085
chr2:113033578-113033579(+) m6A CDS       24981863//27773535//27773536//22608085
chr2:113033585-113033586(+) m6A CDS       24981863//27773535//27773536//22608085
chr2:113057548-113057549(+) m6A CDS//exon       24981863//27773535//22608085
chr2:113057599-113057600(+) m6A CDS//exon       24981863//27773535//22608085
chr2:113060836-113060837(+) m6A CDS//exon       24981863//27773535//22608085
chr2:113060861-113060862(+) m6A CDS//exon       24981863
chr2:113082700-113082701(+) m6A CDS       24981863//22608085
chr2:113082730-113082731(+) m6A CDS       24981863//22608085
chr2:113088649-113088650(+) m6A CDS       24284625//24981863//27773535//22608085
chr2:113088660-113088661(+) m6A CDS       24284625//24981863//27773535//22608085
chr2:113088670-113088671(+) m6A CDS       24284625//24981863//27773535//22608085
chr2:113088702-113088703(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088726-113088727(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088752-113088753(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088778-113088779(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088794-113088795(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088834-113088835(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr2:113088945-113088946(+) m6A CDS       24284625//24209618//24981863//22608085
chr2:113088987-113088988(+) m6A CDS       24284625//24209618//24981863//22608085
chr2:113089065-113089066(+) m6A CDS       24284625//24981863//22608085
chr2:113089088-113089089(+) m6A CDS       24284625//24981863//22608085
chr2:113089104-113089105(+) m6A CDS       24284625//24981863//22608085
chr2:113089119-113089120(+) m6A CDS       24284625//24981863//22608085
chr2:113089142-113089143(+) m6A CDS       24284625//24981863//22608085
chr2:113089167-113089168(+) m6A CDS       24284625//24981863//22608085
chr2:113089319-113089320(+) m6A CDS       24284625//24981863//22608085
chr2:113089338-113089339(+) m6A CDS       24284625//24981863//22608085
chr2:113089349-113089350(+) m6A CDS       24284625//24981863//22608085
chr2:113089386-113089387(+) m6A CDS       24284625//24981863//22608085
chr2:113089419-113089420(+) m6A CDS       24284625//24981863//22608085
chr2:113089499-113089500(+) m6A CDS       24284625//24981863//22608085
chr2:113089531-113089532(+) m6A CDS       24284625//24981863//22608085
chr2:113089575-113089576(+) m6A CDS       24284625//24981863//22608085
chr2:113089606-113089607(+) m6A CDS       24284625//24981863//22608085
chr2:113089703-113089704(+) m6A CDS       24284625//25456834//24981863//22608085
chr2:113089712-113089713(+) m6A CDS       24284625//25456834//24981863//22608085
chr2:113089750-113089751(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr2:113089755-113089756(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr2:113089788-113089789(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr2:113089959-113089960(+) m6A CDS//intron       -
chr2:113096692-113096693(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
ZC3H6
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: ZC3H6

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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