Basic Information:

  VIRBase ID:  

HHID00005445

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          IRF2BP2:  NM_001077397     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	IRF2BP2
miRBase Accession/Entrez ID	MIMAT0000458	359948
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CVID14

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IRF2BP2	chr1:234742686-234742687(-) m6A 3'UTR       26404942//27773535 chr1:234742769-234742770(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234742778-234742779(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234742793-234742794(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234742838-234742839(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234742862-234742863(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234742889-234742890(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234743029-234743030(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234743041-234743042(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:234743102-234743103(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:234743162-234743163(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:234743194-234743195(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:234743252-234743253(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:234743348-234743349(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:234743412-234743413(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:234743535-234743536(-) Am CDS//exon       - chr1:234743560-234743561(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085 chr1:234743589-234743590(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960 chr1:234744330-234744331(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960 chr1:234744350-234744351(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960 chr1:234744463-234744464(-) m6A CDS       24284625//24209618//25456834//28052920//27371828//27773536//22575960 chr1:234744585-234744586(-) m6A CDS       24209618//27371828//27773536//22575960 chr1:234744710-234744711(-) m6A CDS       24284625//24209618//24981863//27371828//27773536//22575960 chr1:234744971-234744972(-) m6A CDS       24209618//24981863//28052920//27371828//27773536//22575960 chr1:234745138-234745139(-) m6A CDS       24284625//24209618//24981863//28052920//27371828//27773536//22575960 chr1:234745148-234745149(-) m6A CDS       24284625//24209618//24981863//28052920//27371828//27773536//22575960 chr1:234745241-234745242(-) m6A 5'UTR       24209618//24981863//28052920//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	IRF2BP2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: IRF2BP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).