Detail Information

Basic Information:


  VIRBase ID:  

HHID00005442

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           HCN1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p HCN1
miRBase
Accession/Entrez ID		 MIMAT0000458 348980
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BCNG-1//BCNG1//DEE24//EIEE24//GEFSP10//HAC-2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HCN1
chr5:45264129(-) A-I      intronic
chr5:45611336(-) A-I      intronic
chr5:45611333(-) A-I      intronic
chr5:45264130(-) A-I      intronic
chr5:45537751(-) A-I      intronic
chr5:45593955(-) A-I      intronic
chr5:45539643(-) A-I      intronic
chr5:45540650(-) A-I      intronic
chr5:45281965(-) A-I      intronic
chr5:45559142(-) A-I      intronic
chr5:45265128(-) A-I      intronic
chr5:45611538(-) A-I      intronic
chr5:45646614(-) A-I      intronic
chr5:45562517(-) A-I      intronic
chr5:45593956(-) A-I      intronic
chr5:45459301(-) A-I      intronic
chr5:45611470(-) A-I      intronic
chr5:45646613(-) A-I      intronic
chr5:45611249(-) A-I      intronic
chr5:45540691(-) A-I      intronic
chr5:45535592(-) A-I      intronic
chr5:45537713(-) A-I      intronic
chr5:45281828(-) A-I      intronic
chr5:45611449(-) A-I      intronic
chr5:45537778(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HCN1
chr5:45262286-45262287(-) m6A CDS       25456834
chr5:45262426-45262427(-) m6A CDS       25456834
chr5:45262459-45262460(-) m6A CDS       25456834
chr5:45262549-45262550(-) m6A CDS       25456834
chr5:45262636-45262637(-) m6A CDS       25456834
chr5:45645569-45645570(-) m6A CDS       24209618
chr5:45645624-45645625(-) m6A CDS       24209618
chr5:45695810-45695811(-) m6A CDS       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
HCN1
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: HCN1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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