Detail Information

Basic Information:


  VIRBase ID:  

HHID00005398

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           TAB3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p TAB3
miRBase
Accession/Entrez ID		 MIMAT0000458 257397
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MAP3K7IP3//NAP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TAB3
chrX:30855268(-) A-I      intronic
chrX:30855271(-) A-I      intronic
chrX:30859346(-) A-I      intronic
chrX:30859390(-) A-I      intronic
chrX:30859456(-) A-I      intronic
chrX:30859488(-) A-I      intronic
chrX:30854860(-) A-I      intronic
chrX:30853021(-) A-I      intronic
chrX:30852940(-) A-I      intronic
chrX:30852923(-) A-I      intronic
chrX:30852825(-) A-I      intronic
chrX:30852776(-) A-I      intronic
chrX:30852967(-) A-I      intronic
chrX:30851214(-) A-I      intronic
chrX:30859498(-) A-I      intronic
chrX:30852778(-) A-I      intronic
chrX:30852835(-) A-I      intronic
chrX:30852806(-) A-I      intronic
chrX:30852767(-) A-I      intronic
chrX:30851259(-) A-I      intronic
chrX:30851252(-) A-I      intronic
chrX:30851216(-) A-I      intronic
chrX:30852821(-) A-I      intronic
chrX:30852803(-) A-I      intronic
chrX:30852810(-) A-I      intronic
chrX:30853015(-) A-I      intronic
chrX:30853013(-) A-I      intronic
chrX:30852986(-) A-I      intronic
chrX:30852976(-) A-I      intronic
chrX:30852962(-) A-I      intronic
chrX:30852953(-) A-I      intronic
chrX:30852952(-) A-I      intronic
chrX:30852905(-) A-I      intronic
chrX:30852886(-) A-I      intronic
chrX:30854898(-) A-I      intronic
chrX:30855196(-) A-I      intronic
chrX:30852768(-) A-I      intronic
chrX:30851180(-) A-I      intronic
chrX:30854873(-) A-I      intronic
chrX:30854848(-) A-I      intronic
chrX:30854716(-) A-I      intronic
chrX:30868729(-) A-I      intronic
chrX:30854910(-) A-I      intronic
chrX:30853022(-) A-I      intronic
chrX:30854841(-) A-I      intronic
chrX:30854788(-) A-I      intronic
chrX:30852866(-) A-I      intronic
chrX:30852849(-) A-I      intronic
chrX:30855226(-) A-I      intronic
chrX:30856323(-) A-I      intronic
chrX:30859284(-) A-I      intronic
chrX:30851692(-) A-I      intronic
chrX:30856454(-) A-I      intronic
chrX:30855330(-) A-I      intronic
chrX:30860042(-) A-I      intronic
chrX:30855345(-) A-I      intronic
chrX:30854742(-) A-I      intronic
chrX:30854756(-) A-I      intronic
chrX:30863041(-) A-I      intronic
chrX:30854757(-) A-I      intronic
chrX:30852822(-) A-I      intronic
chrX:30863055(-) A-I      intronic
chrX:30852892(-) A-I      intronic
chrX:30855277(-) A-I      intronic
chrX:30855274(-) A-I      intronic
chrX:30855403(-) A-I      intronic
chrX:30855304(-) A-I      intronic
chrX:30854908(-) A-I      intronic
chrX:30854743(-) A-I      intronic
chrX:30860158(-) A-I      intronic
chrX:30854836(-) A-I      intronic
chrX:30860912(-) A-I      intronic
chrX:30854695(-) A-I      intronic
chrX:30855343(-) A-I      intronic
chrX:30852876(-) A-I      intronic
chrX:30852830(-) A-I      intronic
chrX:30854703(-) A-I      intronic
chrX:30855445(-) A-I      intronic
chrX:30860028(-) A-I      intronic
chrX:30855451(-) A-I      intronic
chrX:30852992(-) A-I      intronic
chrX:30852770(-) A-I      intronic
chrX:30855339(-) A-I      intronic
chrX:30855344(-) A-I      intronic
chrX:30860856(-) A-I      intronic
chrX:30860090(-) A-I      intronic
chrX:30854825(-) A-I      intronic
chrX:30854755(-) A-I      intronic
chrX:30856543(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TAB3
chrX:30852892(-) A-I intron -    22327324
chrX:30854836(-) A-I intron -    21960545
chrX:30854703(-) A-G intron -    22484847
chrX:30854777(-) A-G intron -    22484847
chrX:30854836(-) A-G intron -    22484847
chrX:30854878(-) A-G intron -    22484847
chrX:30854884(-) A-G intron -    22484847
chrX:30854908(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TAB3
chrX:30845563-30845564(-) m6A 3'UTR       27773535
chrX:30845574-30845575(-) m6A 3'UTR       27773535
chrX:30845618-30845619(-) m6A 3'UTR       27773535
chrX:30845741-30845742(-) m6A 3'UTR       27773535
chrX:30845830-30845831(-) m6A 3'UTR       27773535
chrX:30845835-30845836(-) m6A 3'UTR       27773535
chrX:30846579-30846580(-) m6A 3'UTR       27773535
chrX:30846658-30846659(-) m6A 3'UTR       27773535
chrX:30847659-30847660(-) m6A 3'UTR       27773535
chrX:30847712-30847713(-) m6A 3'UTR       24981863//27773535
chrX:30847740-30847741(-) m6A 3'UTR       24981863//27773535
chrX:30847800-30847801(-) m6A 3'UTR       24981863//27773535
chrX:30847821-30847822(-) m6A 3'UTR       24981863//27773535
chrX:30847890-30847891(-) m6A 3'UTR       27773535
chrX:30847917-30847918(-) m6A 3'UTR       27773535
chrX:30847927-30847928(-) m6A 3'UTR       27773535
chrX:30848048-30848049(-) Y 3'UTR       26075521
chrX:30848076-30848077(-) m6A 3'UTR       27773535
chrX:30848333-30848334(-) m6A 3'UTR       24981863//22608085
chrX:30848341-30848342(-) m6A 3'UTR       24981863//22608085
chrX:30849160-30849161(-) m6A 3'UTR       27773535
chrX:30849313-30849314(-) m6A 3'UTR       24981863//27773535//27371828//22608085
chrX:30849473-30849474(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chrX:30849481-30849482(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chrX:30849509-30849510(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chrX:30849640-30849641(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chrX:30849659-30849660(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chrX:30849683-30849684(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chrX:30852199-30852200(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chrX:30852259-30852260(-) m6A CDS       24284625//24981863//27773535//27371828
chrX:30852741-30852742(-) m6A 3'UTR//intron       24284625//24981863//27773535//27371828
chrX:30852747-30852748(-) m6A 3'UTR//intron       24284625//24981863//27773535//27371828
chrX:30852764-30852765(-) m6A 3'UTR//intron       24981863//27773535//27371828
chrX:30852769-30852770(-) m6A 3'UTR//intron       24981863//27773535//27371828
chrX:30852777-30852778(-) m6A 3'UTR//intron       24981863//27773535//27371828
chrX:30854447-30854448(-) m6A 3'UTR//intron       27773535
chrX:30854508-30854509(-) m6A 3'UTR//intron       27773535
chrX:30854627-30854628(-) m6A 3'UTR//intron       27773535
chrX:30854670-30854671(-) m6A 3'UTR//intron       24981863
chrX:30854840-30854841(-) m6A 3'UTR//intron       -
chrX:30861119-30861120(-) m6A 3'UTR//CDS//exon//intron       27773535
chrX:30861162-30861163(-) m6A 3'UTR//CDS//exon//intron       27773535
chrX:30861890-30861891(-) m6A 3'UTR//intron       -
chrX:30861897-30861898(-) m6A 3'UTR//intron       -
chrX:30861926-30861927(-) m6A 3'UTR//intron       -
chrX:30861942-30861943(-) m6A 3'UTR//intron       27773535
chrX:30861949-30861950(-) m6A 3'UTR//intron       27773535
chrX:30861991-30861992(-) m6A 3'UTR//intron       27773535
chrX:30862062-30862063(-) m6A 3'UTR//intron       27773535
chrX:30872338-30872339(-) m6A CDS       24284625//24981863//27773535//22608085
chrX:30872366-30872367(-) m6A CDS       24284625//24981863//27773535//22608085
chrX:30872432-30872433(-) m6A CDS       24284625//24981863//27773535//22608085
chrX:30872473-30872474(-) m6A CDS       24284625//24981863//27773535//22608085
chrX:30872524-30872525(-) m6A CDS       24284625//24981863//27773535//22608085
chrX:30872649-30872650(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30872656-30872657(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30872668-30872669(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30872755-30872756(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30872773-30872774(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30872932-30872933(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30872960-30872961(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30873055-30873056(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30873082-30873083(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30873163-30873164(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30873176-30873177(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chrX:30873288-30873289(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chrX:30873344-30873345(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chrX:30873349-30873350(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chrX:30873412-30873413(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chrX:30873436-30873437(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chrX:30873466-30873467(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chrX:30873492-30873493(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chrX:30889916-30889917(-) m6A 5'UTR       24209618
chrX:30917210-30917211(-) m6A 5'UTR       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
TAB3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: TAB3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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