Basic Information:

  VIRBase ID:  

HHID00005387

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          CNEP1R1:  NR_104042     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	CNEP1R1
miRBase Accession/Entrez ID	MIMAT0000458	255919
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C16orf69//NEP1-R1//NEP1R1//TMEM188//TMP125

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CNEP1R1	chr16:50068985(+) A-I      intronic chr16:50066683(+) A-I      intronic chr16:50067687(+) A-I      intronic chr16:50067720(+) A-I      intronic chr16:50067763(+) A-I      intronic chr16:50068768(+) A-I      intronic chr16:50068770(+) A-I      intronic chr16:50066701(+) A-I      intronic chr16:50067740(+) A-I      intronic chr16:50060725(+) A-I      intronic chr16:50069001(+) A-I      intronic chr16:50061499(+) A-I      intronic chr16:50062024(+) A-I      intronic chr16:50066730(+) A-I      intronic chr16:50066734(+) A-I      intronic chr16:50062021(+) A-I      intronic chr16:50066754(+) A-I      intronic chr16:50062133(+) A-I      intronic chr16:50062140(+) A-I      intronic chr16:50067654(+) A-I      intronic chr16:50068653(+) A-I      intronic chr16:50062003(+) A-I      intronic chr16:50061172(+) A-I      intronic chr16:50062061(+) A-I      intronic chr16:50062132(+) A-I      intronic chr16:50062081(+) A-I      intronic chr16:50062055(+) A-I      intronic chr16:50060644(+) A-I      intronic chr16:50060738(+) A-I      intronic chr16:50061298(+) A-I      intronic chr16:50062052(+) A-I      intronic chr16:50061995(+) A-I      intronic chr16:50060796(+) A-I      intronic chr16:50067632(+) A-I      intronic chr16:50061204(+) A-I      intronic chr16:50061943(+) A-I      intronic chr16:50060670(+) A-I      intronic chr16:50061889(+) A-I      intronic chr16:50062008(+) A-I      intronic chr16:50060710(+) A-I      intronic chr16:50068667(+) A-I      intronic chr16:50067520(+) A-I      intronic chr16:50060829(+) A-I      intronic chr16:50061157(+) A-I      intronic chr16:50061565(+) A-I      intronic chr16:50060617(+) A-I      intronic chr16:50062072(+) A-I      intronic chr16:50062034(+) A-I      intronic chr16:50061272(+) A-I      intronic chr16:50061243(+) A-I      intronic chr16:50060721(+) A-I      intronic chr16:50068648(+) A-I      intronic chr16:50067924(+) A-I      intronic chr16:50067519(+) A-I      intronic chr16:50062092(+) A-I      intronic chr16:50060622(+) A-I      intronic chr16:50061449(+) A-I      intronic chr16:50061242(+) A-I      intronic chr16:50061998(+) A-I      intronic chr16:50061899(+) A-I      intronic chr16:50062146(+) A-I      intronic chr16:50068692(+) A-I      intronic chr16:50061494(+) A-I      intronic chr16:50069008(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CNEP1R1	chr16:50062140(+) A-I intron -    22327324 chr16:50069772(+) A-I intron -    21960545 chr16:50061298(+) A-G intron -    22484847 chr16:50062140(+) A-G intron -    22484847 chr16:50067654(+) A-G intron -    22484847 chr16:50070116(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CNEP1R1	chr16:50059190-50059191(+) m6A 5'UTR//exon       24981863 chr16:50059230-50059231(+) m6A CDS//exon       24981863 chr16:50069335-50069336(+) m6A 3'UTR//CDS       24981863 chr16:50069347-50069348(+) m6A 3'UTR//CDS       24981863 chr16:50069392-50069393(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	CNEP1R1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: CNEP1R1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).