Detail Information

Basic Information:


  VIRBase ID:  

HHID00005333

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           DHX36:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p DHX36
miRBase
Accession/Entrez ID		 MIMAT0000458 170506
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DDX36//G4R1//MLEL1//RHAU

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DHX36
chr3:154013760(-) A-I      intronic
chr3:154013730(-) A-I      intronic
chr3:154013776(-) A-I      intronic
chr3:154014019(-) A-I      intronic
chr3:154014021(-) A-I      intronic
chr3:154014082(-) A-I      intronic
chr3:154014163(-) A-I      intronic
chr3:154014176(-) A-I      intronic
chr3:154004725(-) A-I      intronic
chr3:154014187(-) A-I      intronic
chr3:153993280(-) A-I      3'UTR
chr3:154004729(-) A-I      intronic
chr3:154013654(-) A-I      intronic
chr3:154013751(-) A-I      intronic
chr3:154013824(-) A-I      intronic
chr3:154016950(-) A-I      intronic
chr3:154016881(-) A-I      intronic
chr3:154013821(-) A-I      intronic
chr3:154002243(-) A-I      intronic
chr3:153991878(-) A-I      3'UTR
chr3:153992014(-) A-I      3'UTR
chr3:154015391(-) A-I      intronic
chr3:153996390(-) A-I      intronic
chr3:154013752(-) A-I      intronic
chr3:154016523(-) A-I      intronic
chr3:154013649(-) A-I      intronic
chr3:154013642(-) A-I      intronic
chr3:154013685(-) A-I      intronic
chr3:154017065(-) A-I      intronic
chr3:154013619(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DHX36
chr3:154013619(-) A-G intron -    22484847
chr3:154013642(-) A-G intron -    22484847
chr3:154013649(-) A-G intron -    22484847
chr3:154013745(-) A-G intron -    22484847
chr3:154013752(-) A-G intron -    22484847
chr3:154013753(-) A-G intron -    22484847
chr3:154014074(-) A-G intron -    22484847
chr3:154016523(-) A-G intron -    22484847
chr3:154016881(-) A-G intron -    22484847
chr3:154016890(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DHX36
chr3:153992184-153992185(-) m6A 3'UTR       22608085
chr3:153992205-153992206(-) m6A 3'UTR       22608085
chr3:153992275-153992276(-) m6A 3'UTR       24981863//22608085
chr3:153992303-153992304(-) m6A 3'UTR       24981863//22608085
chr3:153992309-153992310(-) m6A 3'UTR       24981863//22608085
chr3:153992315-153992316(-) m6A 3'UTR       24981863//22608085
chr3:153992346-153992347(-) m6A 3'UTR       22608085
chr3:153993528-153993529(-) m6A 3'UTR       27773535
chr3:153993553-153993554(-) m6A 3'UTR       27773535
chr3:153993576-153993577(-) m6A 3'UTR       27773535
chr3:153993823-153993824(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr3:153993867-153993868(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr3:153993873-153993874(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153993881-153993882(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153993996-153993997(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153994021-153994022(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153994032-153994033(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:153994059-153994060(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:153994083-153994084(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:153994130-153994131(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:153994363-153994364(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:154018786-154018787(-) m6A CDS       24981863//27773535
chr3:154018846-154018847(-) m6A CDS       24981863//27773535
chr3:154018894-154018895(-) m6A CDS       24981863//27773535
chr3:154018903-154018904(-) m6A CDS       24981863//27773535
chr3:154027527-154027528(-) Y CDS       26075521
chr3:154029480-154029481(-) m6A exon//intron       27773535
chr3:154032895-154032896(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154032902-154032903(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154032912-154032913(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154032961-154032962(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:154033024-154033025(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22608085
chr3:154033042-154033043(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22608085
chr3:154033889-154033890(-) Y CDS//exon       25219674
chr3:154033916-154033917(-) m6A CDS//exon       24209618//24981863//27773535//27371828
chr3:154036929-154036930(-) m1A 5'UTR//intron       26863196
chr3:154036937-154036938(-) m6A 5'UTR//intron       24209618//24981863//27773535//27371828
chr3:154041984-154041985(-) m6A CDS//exon       24209618//24981863//27773535//27371828//27773536//22575960
chr3:154041998-154041999(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr3:154042182-154042183(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr3:154042207-154042208(-) m6A 5'UTR       24284625//25456834//24981863//27773535//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
DHX36
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: DHX36

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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