Basic Information:

  VIRBase ID:  

HHID00005320

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          ZNF567:  NM_001322920     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	ZNF567
miRBase Accession/Entrez ID	MIMAT0000458	163081
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF567	chr19:37182186(+) A-I      intronic chr19:37182160(+) A-I      intronic chr19:37203049(+) A-I      intronic chr19:37209326(+) A-I      intronic chr19:37209333(+) A-I      intronic chr19:37204765(+) A-I      intronic chr19:37204758(+) A-I      intronic chr19:37204757(+) A-I      intronic chr19:37209286(+) A-I      intronic chr19:37181293(+) A-I      intronic chr19:37204656(+) A-I      intronic chr19:37183342(+) A-I      intronic chr19:37183414(+) A-I      intronic chr19:37182190(+) A-I      intronic chr19:37183439(+) A-I      intronic chr19:37183330(+) A-I      intronic chr19:37184000(+) A-I      intronic chr19:37182083(+) A-I      intronic chr19:37203971(+) A-I      intronic chr19:37181294(+) A-I      intronic chr19:37209384(+) A-I      intronic chr19:37205163(+) A-I      intronic chr19:37207832(+) A-I      intronic chr19:37207991(+) A-I      intronic chr19:37209280(+) A-I      intronic chr19:37209281(+) A-I      intronic chr19:37183344(+) A-I      intronic chr19:37184059(+) A-I      intronic chr19:37207808(+) A-I      intronic chr19:37205157(+) A-I      intronic chr19:37205095(+) A-I      intronic chr19:37183952(+) A-I      intronic chr19:37181381(+) A-I      intronic chr19:37186284(+) A-I      intronic chr19:37206126(+) A-I      intronic chr19:37207990(+) A-I      intronic chr19:37183540(+) A-I      intronic chr19:37204756(+) A-I      intronic chr19:37203185(+) A-I      intronic chr19:37202074(+) A-I      intronic chr19:37183420(+) A-I      intronic chr19:37204066(+) A-I      intronic chr19:37207746(+) A-I      intronic chr19:37207911(+) A-I      intronic chr19:37185045(+) A-I      intronic chr19:37181313(+) A-I      intronic chr19:37184336(+) A-I      intronic chr19:37206102(+) A-I      intronic chr19:37204461(+) A-I      intronic chr19:37182296(+) A-I      intronic chr19:37205266(+) A-I      intronic chr19:37205189(+) A-I      intronic chr19:37207797(+) A-I      intronic chr19:37207867(+) A-I      intronic chr19:37204147(+) A-I      intronic chr19:37182084(+) A-I      intronic chr19:37203953(+) A-I      intronic chr19:37183498(+) A-I      intronic chr19:37183404(+) A-I      intronic chr19:37183325(+) A-I      intronic chr19:37181309(+) A-I      intronic chr19:37209205(+) A-I      intronic chr19:37182689(+) A-I      intronic chr19:37209130(+) A-I      intronic chr19:37181233(+) A-I      intronic chr19:37183328(+) A-I      intronic chr19:37181240(+) A-I      intronic chr19:37207914(+) A-I      intronic chr19:37182692(+) A-I      intronic chr19:37204028(+) A-I      intronic chr19:37183506(+) A-I      intronic chr19:37186448(+) A-I      intronic chr19:37182694(+) A-I      intronic chr19:37202073(+) A-I      intronic chr19:37204451(+) A-I      intronic chr19:37204158(+) A-I      intronic chr19:37202153(+) A-I      intronic chr19:37203048(+) A-I      intronic chr19:37204432(+) A-I      intronic chr19:37209140(+) A-I      intronic chr19:37202178(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF567	chr19:37181233(+) A-G intron -    22484847 chr19:37182692(+) A-G intron -    22484847 chr19:37182694(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF567	chr19:37180345-37180346(+) m6A 5'UTR//exon       25456834//24981863 chr19:37180358-37180359(+) m6A 5'UTR//exon       25456834//24981863 chr19:37185705-37185706(+) m6A 5'UTR//exon//intron       - chr19:37203741-37203742(+) m6A CDS       22608085 chr19:37209855-37209856(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209870-37209871(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209892-37209893(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209940-37209941(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209974-37209975(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37209993-37209994(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210099-37210100(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210144-37210145(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210151-37210152(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210238-37210239(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210315-37210316(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210332-37210333(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210381-37210382(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210462-37210463(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210529-37210530(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210546-37210547(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210589-37210590(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210613-37210614(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210697-37210698(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210714-37210715(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210757-37210758(+) m6A CDS//intron       24981863//22608085 chr19:37210798-37210799(+) m6A CDS//intron       24981863//22608085 chr19:37210865-37210866(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210925-37210926(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37210949-37210950(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37210966-37210967(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37211009-37211010(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211033-37211034(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211117-37211118(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211134-37211135(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211177-37211178(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211218-37211219(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr19:37211369-37211370(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr19:37211386-37211387(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr19:37211429-37211430(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr19:37211453-37211454(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211470-37211471(+) m6A CDS//intron       24209618//24981863//27773535//22608085 chr19:37211517-37211518(+) m6A CDS//intron       24981863//27773535//22608085 chr19:37211537-37211538(+) m6A CDS//intron       24981863//22608085 chr19:37211553-37211554(+) m6A CDS//intron       24981863//22608085 chr19:37211612-37211613(+) m6A 3'UTR//intron       24981863 chr19:37211644-37211645(+) m6A 3'UTR//intron       24981863 chr19:37211753-37211754(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	ZNF567	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: ZNF567

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).