Basic Information:

  VIRBase ID:  

HHID00005318

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          SLFN5:  NM_001330183     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	SLFN5
miRBase Accession/Entrez ID	MIMAT0000458	162394
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLFN5	chr17:33590682(+) A-I      intronic chr17:33590643(+) A-I      intronic chr17:33590333(+) A-I      intronic chr17:33590229(+) A-I      intronic chr17:33589808(+) A-I      intronic chr17:33590295(+) A-I      intronic chr17:33590699(+) A-I      intronic chr17:33590291(+) A-I      intronic chr17:33590727(+) A-I      intronic chr17:33590691(+) A-I      intronic chr17:33590711(+) A-I      intronic chr17:33590695(+) A-I      intronic chr17:33590683(+) A-I      intronic chr17:33590692(+) A-I      intronic chr17:33590666(+) A-I      intronic chr17:33589727(+) A-I      intronic chr17:33589320(+) A-I      intronic chr17:33589680(+) A-I      intronic chr17:33578813(+) A-I      intronic chr17:33589696(+) A-I      intronic chr17:33571791(+) A-I      intronic chr17:33589870(+) A-I      intronic chr17:33571786(+) A-I      intronic chr17:33589798(+) A-I      intronic chr17:33590754(+) A-I      intronic chr17:33590738(+) A-I      intronic chr17:33578684(+) A-I      intronic chr17:33590299(+) A-I      intronic chr17:33578826(+) A-I      intronic chr17:33590181(+) A-I      intronic chr17:33578703(+) A-I      intronic chr17:33578953(+) A-I      intronic chr17:33571689(+) A-I      intronic chr17:33590770(+) A-I      intronic chr17:33589252(+) A-I      intronic chr17:33579356(+) A-I      intronic chr17:33588918(+) A-I      intronic chr17:33590772(+) A-I      intronic chr17:33588751(+) A-I      intronic chr17:33588798(+) A-I      intronic chr17:33588427(+) A-I      intronic chr17:33589756(+) A-I      intronic chr17:33590430(+) A-I      intronic chr17:33578685(+) A-I      intronic chr17:33590819(+) A-I      intronic chr17:33590219(+) A-I      intronic chr17:33589815(+) A-I      intronic chr17:33578850(+) A-I      intronic chr17:33578756(+) A-I      intronic chr17:33590686(+) A-I      intronic chr17:33589691(+) A-I      intronic chr17:33590757(+) A-I      intronic chr17:33588872(+) A-I      intronic chr17:33588472(+) A-I      intronic chr17:33590843(+) A-I      intronic chr17:33590230(+) A-I      intronic chr17:33579376(+) A-I      intronic chr17:33588492(+) A-I      intronic chr17:33590777(+) A-I      intronic chr17:33588974(+) A-I      intronic chr17:33571881(+) A-I      intronic chr17:33588597(+) A-I      intronic chr17:33590359(+) A-I      intronic chr17:33588972(+) A-I      intronic chr17:33590818(+) A-I      intronic chr17:33590440(+) A-I      intronic chr17:33590684(+) A-I      intronic chr17:33590250(+) A-I      intronic chr17:33588898(+) A-I      intronic chr17:33588794(+) A-I      intronic chr17:33588609(+) A-I      intronic chr17:33589242(+) A-I      intronic chr17:33588795(+) A-I      intronic chr17:33588775(+) A-I      intronic chr17:33589681(+) A-I      intronic chr17:33590254(+) A-I      intronic chr17:33588834(+) A-I      intronic chr17:33590774(+) A-I      intronic chr17:33579351(+) A-I      intronic chr17:33590840(+) A-I      intronic chr17:33589858(+) A-I      intronic chr17:33588830(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLFN5	chr17:33588472(+) A-G intron -    22484847 chr17:33590254(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLFN5	chr17:33570101-33570102(+) m6A 5'UTR       - chr17:33570153-33570154(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33585673-33585674(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33585737-33585738(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33585781-33585782(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:33585803-33585804(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:33585822-33585823(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:33585899-33585900(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33585986-33585987(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586016-33586017(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:33586075-33586076(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr17:33586129-33586130(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr17:33586135-33586136(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr17:33586266-33586267(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586337-33586338(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586411-33586412(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586448-33586449(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:33586658-33586659(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr17:33586671-33586672(+) m6A CDS       24284625//24209618//24981863 chr17:33586693-33586694(+) m6A CDS       24284625//24209618//24981863 chr17:33591210-33591211(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr17:33591247-33591248(+) m6A CDS//intron       24284625//24981863//22608085 chr17:33591268-33591269(+) m6A CDS//intron       24284625//24981863//22608085 chr17:33591276-33591277(+) m6A CDS//intron       24284625//24981863//22608085 chr17:33591402-33591403(+) m6A CDS//intron       24284625//24981863 chr17:33591723-33591724(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591739-33591740(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591762-33591763(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591773-33591774(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591815-33591816(+) m6A CDS//intron       24284625//22575960 chr17:33591868-33591869(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33591897-33591898(+) m6A CDS//intron       24284625//24981863//22575960 chr17:33592104-33592105(+) m6A CDS       24284625//24209618//24981863//22575960 chr17:33592130-33592131(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592143-33592144(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592153-33592154(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592209-33592210(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592241-33592242(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960 chr17:33592281-33592282(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863 chr17:33592292-33592293(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863 chr17:33592332-33592333(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr17:33592471-33592472(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592518-33592519(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592524-33592525(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592644-33592645(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592675-33592676(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592758-33592759(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960 chr17:33592876-33592877(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22575960//22608085 chr17:33592913-33592914(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33592928-33592929(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33592964-33592965(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33592978-33592979(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr17:33593073-33593074(+) m6A 3'UTR       24284625//24209618//24981863 chr17:33593100-33593101(+) m6A 3'UTR       24284625//24209618//24981863 chr17:33593144-33593145(+) m6A 3'UTR       24284625//24981863 chr17:33593152-33593153(+) m6A 3'UTR       24284625//24981863 chr17:33593280-33593281(+) m6A 3'UTR       24284625 chr17:33593314-33593315(+) m6A 3'UTR       24284625 chr17:33594757-33594758(+) m6A 3'UTR       24981863 chr17:33595353-33595354(+) m6A 3'UTR       24981863 chr17:33595402-33595403(+) m6A 3'UTR       24981863 chr17:33595433-33595434(+) m6A 3'UTR       24981863 chr17:33595440-33595441(+) m6A 3'UTR       24981863 chr17:33596511-33596512(+) m6A 3'UTR       24981863 chr17:33596547-33596548(+) m6A 3'UTR       24981863 chr17:33596618-33596619(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	SLFN5	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: SLFN5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).