Basic Information:

  VIRBase ID:  

HHID00005309

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PABIR2:  NM_001331089     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PABIR2
miRBase Accession/Entrez ID	MIMAT0000458	159090
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM122B//SPACIA2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PABIR2	chrX:133911701(-) A-I      intronic chrX:133911699(-) A-I      intronic chrX:133911641(-) A-I      intronic chrX:133911493(-) A-I      intronic chrX:133911474(-) A-I      intronic chrX:133911444(-) A-I      intronic chrX:133911312(-) A-I      intronic chrX:133911986(-) A-I      intronic chrX:133912117(-) A-I      intronic chrX:133912118(-) A-I      intronic chrX:133912126(-) A-I      intronic chrX:133913331(-) A-I      intronic chrX:133913415(-) A-I      intronic chrX:133912020(-) A-I      intronic chrX:133918776(-) A-I      intronic chrX:133920950(-) A-I      intronic chrX:133920940(-) A-I      intronic chrX:133920798(-) A-I      intronic chrX:133919668(-) A-I      intronic chrX:133919568(-) A-I      intronic chrX:133918757(-) A-I      intronic chrX:133918678(-) A-I      intronic chrX:133918676(-) A-I      intronic chrX:133918593(-) A-I      intronic chrX:133918412(-) A-I      intronic chrX:133917655(-) A-I      intronic chrX:133913116(-) A-I      intronic chrX:133912982(-) A-I      intronic chrX:133912878(-) A-I      intronic chrX:133912533(-) A-I      intronic chrX:133912488(-) A-I      intronic chrX:133912477(-) A-I      intronic chrX:133912475(-) A-I      intronic chrX:133912439(-) A-I      intronic chrX:133912385(-) A-I      intronic chrX:133912369(-) A-I      intronic chrX:133912278(-) A-I      intronic chrX:133911784(-) A-I      intronic chrX:133911782(-) A-I      intronic chrX:133911718(-) A-I      intronic chrX:133911704(-) A-I      intronic chrX:133913337(-) A-I      intronic chrX:133911717(-) A-I      intronic chrX:133912136(-) A-I      intronic chrX:133911957(-) A-I      intronic chrX:133912099(-) A-I      intronic chrX:133913319(-) A-I      intronic chrX:133918735(-) A-I      intronic chrX:133918779(-) A-I      intronic chrX:133918765(-) A-I      intronic chrX:133918383(-) A-I      intronic chrX:133909301(-) A-I      intronic chrX:133913410(-) A-I      intronic chrX:133911656(-) A-I      intronic chrX:133912007(-) A-I      intronic chrX:133921197(-) A-I      intronic chrX:133911992(-) A-I      intronic chrX:133912422(-) A-I      intronic chrX:133913335(-) A-I      intronic chrX:133912052(-) A-I      intronic chrX:133911754(-) A-I      intronic chrX:133911374(-) A-I      intronic chrX:133911499(-) A-I      intronic chrX:133913399(-) A-I      intronic chrX:133912190(-) A-I      intronic chrX:133921419(-) A-I      intronic chrX:133912142(-) A-I      intronic chrX:133911520(-) A-I      intronic chrX:133912009(-) A-I      intronic chrX:133911434(-) A-I      intronic chrX:133912141(-) A-I      intronic chrX:133913347(-) A-I      intronic chrX:133920426(-) A-I      intronic chrX:133921409(-) A-I      intronic chrX:133918431(-) A-I      intronic chrX:133913229(-) A-I      intronic chrX:133912061(-) A-I      intronic chrX:133918681(-) A-I      intronic chrX:133912079(-) A-I      intronic chrX:133918064(-) A-I      intronic chrX:133921913(-) A-I      intronic chrX:133917937(-) A-I      intronic chrX:133918605(-) A-I      intronic chrX:133911650(-) A-I      intronic chrX:133911473(-) A-I      intronic chrX:133912139(-) A-I      intronic chrX:133914547(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	PABIR2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PABIR2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).