Basic Information:

  VIRBase ID:  

HHID00005305

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PRAG1:  NM_001369759     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PRAG1
miRBase Accession/Entrez ID	MIMAT0000458	157285
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NACK//PEAK2//PRAGMIN//SGK223

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRAG1	chr8:8189898(-) A-I      intronic chr8:8199876(-) A-I      intronic chr8:8223388(-) A-I      intronic chr8:8223387(-) A-I      intronic chr8:8223384(-) A-I      intronic chr8:8223372(-) A-I      intronic chr8:8202875(-) A-I      intronic chr8:8203189(-) A-I      intronic chr8:8211317(-) A-I      intronic chr8:8206910(-) A-I      intronic chr8:8205597(-) A-I      intronic chr8:8203187(-) A-I      intronic chr8:8203181(-) A-I      intronic chr8:8199984(-) A-I      intronic chr8:8199820(-) A-I      intronic chr8:8199633(-) A-I      intronic chr8:8203199(-) A-I      intronic chr8:8211297(-) A-I      intronic chr8:8223364(-) A-I      intronic chr8:8199564(-) A-I      intronic chr8:8199539(-) A-I      intronic chr8:8199525(-) A-I      intronic chr8:8199457(-) A-I      intronic chr8:8207711(-) A-I      intronic chr8:8189882(-) A-I      intronic chr8:8187806(-) A-I      intronic chr8:8186691(-) A-I      intronic chr8:8183316(-) A-I      intronic chr8:8183305(-) A-I      intronic chr8:8180910(-) A-I      intronic chr8:8179877(-) A-I      intronic chr8:8179874(-) A-I      intronic chr8:8199837(-) A-I      intronic chr8:8223287(-) A-I      intronic chr8:8223028(-) A-I      intronic chr8:8223016(-) A-I      intronic chr8:8222973(-) A-I      intronic chr8:8222867(-) A-I      intronic chr8:8214000(-) A-I      intronic chr8:8213927(-) A-I      intronic chr8:8211319(-) A-I      intronic chr8:8225269(-) A-I      intronic chr8:8225263(-) A-I      intronic chr8:8209873(-) A-I      intronic chr8:8211285(-) A-I      intronic chr8:8207809(-) A-I      intronic chr8:8209840(-) A-I      intronic chr8:8209841(-) A-I      intronic chr8:8233314(-) A-I      intronic chr8:8233278(-) A-I      intronic chr8:8229787(-) A-I      intronic chr8:8229773(-) A-I      intronic chr8:8229237(-) A-I      intronic chr8:8209890(-) A-I      intronic chr8:8209905(-) A-I      intronic chr8:8229113(-) A-I      intronic chr8:8229054(-) A-I      intronic chr8:8179782(-) A-I      intronic chr8:8229025(-) A-I      intronic chr8:8229012(-) A-I      intronic chr8:8228978(-) A-I      intronic chr8:8228949(-) A-I      intronic chr8:8228947(-) A-I      intronic chr8:8228945(-) A-I      intronic chr8:8228888(-) A-I      intronic chr8:8228646(-) A-I      intronic chr8:8228590(-) A-I      intronic chr8:8225430(-) A-I      intronic chr8:8225429(-) A-I      intronic chr8:8225338(-) A-I      intronic chr8:8225329(-) A-I      intronic chr8:8225326(-) A-I      intronic chr8:8225255(-) A-I      intronic chr8:8225234(-) A-I      intronic chr8:8225230(-) A-I      intronic chr8:8225191(-) A-I      intronic chr8:8225165(-) A-I      intronic chr8:8224922(-) A-I      intronic chr8:8224862(-) A-I      intronic chr8:8207698(-) A-I      intronic chr8:8223864(-) A-I      intronic chr8:8224811(-) A-I      intronic chr8:8224808(-) A-I      intronic chr8:8224781(-) A-I      intronic chr8:8224338(-) A-I      intronic chr8:8224111(-) A-I      intronic chr8:8224086(-) A-I      intronic chr8:8224073(-) A-I      intronic chr8:8223939(-) A-I      intronic chr8:8223892(-) A-I      intronic chr8:8223427(-) A-I      intronic chr8:8229831(-) A-I      intronic chr8:8192432(-) A-I      intronic chr8:8223413(-) A-I      intronic chr8:8225391(-) A-I      intronic chr8:8223967(-) A-I      intronic chr8:8224229(-) A-I      intronic chr8:8225173(-) A-I      intronic chr8:8229372(-) A-I      intronic chr8:8224363(-) A-I      intronic chr8:8199778(-) A-I      intronic chr8:8181024(-) A-I      intronic chr8:8224089(-) A-I      intronic chr8:8229755(-) A-I      intronic chr8:8229375(-) A-I      intronic chr8:8228565(-) A-I      intronic chr8:8229141(-) A-I      intronic chr8:8186674(-) A-I      intronic chr8:8199946(-) A-I      intronic chr8:8229264(-) A-I      intronic chr8:8229310(-) A-I      intronic chr8:8199625(-) A-I      intronic chr8:8213958(-) A-I      intronic chr8:8205538(-) A-I      intronic chr8:8223088(-) A-I      intronic chr8:8228944(-) A-I      intronic chr8:8228492(-) A-I      intronic chr8:8229324(-) A-I      intronic chr8:8228570(-) A-I      intronic chr8:8187825(-) A-I      intronic chr8:8229367(-) A-I      intronic chr8:8231058(-) A-I      intronic chr8:8224002(-) A-I      intronic chr8:8223018(-) A-I      intronic chr8:8180982(-) A-I      intronic chr8:8225254(-) A-I      intronic chr8:8229228(-) A-I      intronic chr8:8184920(-) A-I      intronic chr8:8228953(-) A-I      intronic chr8:8228539(-) A-I      intronic chr8:8228443(-) A-I      intronic chr8:8206921(-) A-I      intronic chr8:8223972(-) A-I      intronic chr8:8184901(-) A-I      intronic chr8:8223994(-) A-I      intronic chr8:8223080(-) A-I      intronic chr8:8211247(-) A-I      intronic chr8:8213953(-) A-I      intronic chr8:8211292(-) A-I      intronic chr8:8222883(-) A-I      intronic chr8:8186849(-) A-I      intronic chr8:8229258(-) A-I      intronic chr8:8183317(-) A-I      intronic chr8:8199817(-) A-I      intronic chr8:8211320(-) A-I      intronic chr8:8223444(-) A-I      intronic chr8:8229274(-) A-I      intronic chr8:8224917(-) A-I      intronic chr8:8228552(-) A-I      intronic chr8:8228540(-) A-I      intronic chr8:8224291(-) A-I      intronic chr8:8213930(-) A-I      intronic chr8:8228530(-) A-I      intronic chr8:8224892(-) A-I      intronic chr8:8223954(-) A-I      intronic chr8:8185072(-) A-I      intronic chr8:8225295(-) A-I      intronic chr8:8184974(-) A-I      intronic chr8:8225452(-) A-I      intronic chr8:8228905(-) A-I      intronic chr8:8225325(-) A-I      intronic chr8:8186743(-) A-I      intronic chr8:8224817(-) A-I      intronic chr8:8228489(-) A-I      intronic chr8:8229763(-) A-I      intronic chr8:8228948(-) A-I      intronic chr8:8223374(-) A-I      intronic chr8:8211271(-) A-I      intronic chr8:8231133(-) A-I      intronic chr8:8224468(-) A-I      intronic chr8:8223990(-) A-I      intronic chr8:8213983(-) A-I      intronic chr8:8199565(-) A-I      intronic chr8:8199392(-) A-I      intronic chr8:8225322(-) A-I      intronic chr8:8189939(-) A-I      intronic chr8:8228434(-) A-I      intronic chr8:8229047(-) A-I      intronic chr8:8186746(-) A-I      intronic chr8:8224852(-) A-I      intronic chr8:8181113(-) A-I      intronic chr8:8229304(-) A-I      intronic chr8:8224367(-) A-I      intronic chr8:8186876(-) A-I      intronic chr8:8224855(-) A-I      intronic chr8:8206794(-) A-I      intronic chr8:8222935(-) A-I      intronic chr8:8205684(-) A-I      intronic chr8:8223488(-) A-I      intronic chr8:8199535(-) A-I      intronic chr8:8228941(-) A-I      intronic chr8:8228915(-) A-I      intronic chr8:8224062(-) A-I      intronic chr8:8224332(-) A-I      intronic chr8:8185026(-) A-I      intronic chr8:8178873(-) A-I      intronic chr8:8224278(-) A-I      intronic chr8:8228569(-) A-I      intronic chr8:8225302(-) A-I      intronic chr8:8225362(-) A-I      intronic chr8:8185080(-) A-I      intronic chr8:8179861(-) A-I      intronic chr8:8228960(-) A-I      intronic chr8:8186787(-) A-I      intronic chr8:8178729(-) A-I      intronic chr8:8199560(-) A-I      intronic chr8:8228499(-) A-I      intronic chr8:8199847(-) A-I      intronic chr8:8224364(-) A-I      intronic chr8:8224393(-) A-I      intronic chr8:8181043(-) A-I      intronic chr8:8223057(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	PRAG1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PRAG1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).