Basic Information:

  VIRBase ID:  

HHID00005304

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          ATP6V0E2:  NM_001367791     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	ATP6V0E2
miRBase Accession/Entrez ID	MIMAT0000458	155066
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATP6V0E2L//C7orf32

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATP6V0E2	chr7:149573279(+) A-I      intronic chr7:149573371(+) A-I      intronic chr7:149573386(+) A-I      intronic chr7:149574444(+) A-I      intronic chr7:149574539(+) A-I      intronic chr7:149573415(+) A-I      intronic chr7:149573447(+) A-I      intronic chr7:149574413(+) A-I      intronic chr7:149574460(+) A-I      intronic chr7:149574365(+) A-I      intronic chr7:149574518(+) A-I      intronic chr7:149574471(+) A-I      intronic chr7:149574455(+) A-I      intronic chr7:149574348(+) A-I      intronic chr7:149574535(+) A-I      intronic chr7:149573283(+) A-I      intronic chr7:149574411(+) A-I      intronic chr7:149574545(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATP6V0E2	chr7:149575569(+) A-I intron -    15342557   //15258596 chr7:149575575(+) A-I intron -    15342557   //15258596 chr7:149575590(+) A-I intron -    15342557   //15258596 chr7:149575594(+) A-I intron -    15342557   //15258596 chr7:149575650(+) A-I intron -    15342557   //15258596 chr7:149575652(+) A-I intron -    15342557   //15258596 chr7:149575654(+) A-I intron -    15342557   //15258596 chr7:149575688(+) A-I intron -    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATP6V0E2	chr7:149570602-149570603(+) m6A 5'UTR       24981863//27371828//27773536//22608085 chr7:149570616-149570617(+) m6A 5'UTR       24981863//27371828//27773536//22608085 chr7:149570625-149570626(+) m6A 5'UTR       27773536//22608085 chr7:149570779-149570780(+) m6A 5'UTR       25456834//27773536 chr7:149570793-149570794(+) m6A 5'UTR       25456834//27773536 chr7:149570867-149570868(+) m6A 5'UTR       25456834 chr7:149570888-149570889(+) m6A 5'UTR       - chr7:149571090-149571091(+) m6A 5'UTR//CDS       24981863 chr7:149575795-149575796(+) m6A 3'UTR//CDS//exon//intron       - chr7:149575827-149575828(+) m6A 3'UTR//CDS//exon//intron       24284625 chr7:149575921-149575922(+) m6A 3'UTR//intron       24284625 chr7:149576273-149576274(+) m6A 3'UTR//intron       - chr7:149576480-149576481(+) m6A 3'UTR//CDS//exon       - chr7:149576750-149576751(+) m6A 3'UTR//CDS       25456834//24981863//26404942 chr7:149576771-149576772(+) m6A 3'UTR       25456834//24981863//26404942 chr7:149576855-149576856(+) m6A 3'UTR       25456834//24981863 chr7:149577392-149577393(+) m6A 3'UTR       24284625//24209618 chr7:149577532-149577533(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr7:149577746-149577747(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	ATP6V0E2	Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: ATP6V0E2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).