Basic Information:

  VIRBase ID:  

HHID00005298

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          TMEM161B:  NM_001289008     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	TMEM161B
miRBase Accession/Entrez ID	MIMAT0000458	153396
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FLB3342//PRO1313

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM161B	chr5:87525678(-) A-I      intronic chr5:87525658(-) A-I      intronic chr5:87517234(-) A-I      intronic chr5:87507510(-) A-I      intronic chr5:87517264(-) A-I      intronic chr5:87517954(-) A-I      intronic chr5:87525740(-) A-I      intronic chr5:87530671(-) A-I      intronic chr5:87517153(-) A-I      intronic chr5:87517240(-) A-I      intronic chr5:87518024(-) A-I      intronic chr5:87528664(-) A-I      intronic chr5:87522897(-) A-I      intronic chr5:87517181(-) A-I      intronic chr5:87525684(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMEM161B	chr5:87517240(-) A-G intron -    22484847 chr5:87517264(-) A-G intron -    22484847 chr5:87525684(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM161B	chr5:87485541-87485542(-) m6A 3'UTR       27773535 chr5:87491557-87491558(-) Y 3'UTR//intron       26075521 chr5:87491917-87491918(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr5:87491951-87491952(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr5:87492079-87492080(-) Y 3'UTR//CDS//intron       26075521 chr5:87492120-87492121(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr5:87564589-87564590(-) m6A 5'UTR//exon//intron       24981863 chr5:87564611-87564612(-) m6A 5'UTR//exon       24981863 chr5:87564650-87564651(-) m6A 5'UTR//exon       24981863 chr5:87564693-87564694(-) m6A exon       25456834//24981863 chr5:87565183-87565184(-) m6A exon       24284625//24981863//22608085 chr5:87565200-87565201(-) m6A exon       24284625//24981863//22608085 chr5:87565266-87565267(-) m6A exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	TMEM161B	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: TMEM161B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).