Basic Information:

  VIRBase ID:  

HHID00005297

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          CREBRF:  NM_001168394     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	CREBRF
miRBase Accession/Entrez ID	MIMAT0000458	153222
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C5orf41//LRF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CREBRF	chr5:172487333(+) A-I      ncRNA chr5:172487431(+) A-I      ncRNA chr5:172487434(+) A-I      ncRNA chr5:172487334(+) A-I      ncRNA chr5:172487367(+) A-I      ncRNA chr5:172487399(+) A-I      ncRNA chr5:172487408(+) A-I      ncRNA chr5:172487423(+) A-I      ncRNA chr5:172487424(+) A-I      ncRNA chr5:172516088(+) A-I      intronic chr5:172516062(+) A-I      intronic chr5:172516061(+) A-I      intronic chr5:172514715(+) A-I      intronic chr5:172514605(+) A-I      intronic chr5:172514468(+) A-I      intronic chr5:172514467(+) A-I      intronic chr5:172514446(+) A-I      intronic chr5:172514349(+) A-I      intronic chr5:172513897(+) A-I      intronic chr5:172512208(+) A-I      intronic chr5:172512135(+) A-I      intronic chr5:172510059(+) A-I      intronic chr5:172510042(+) A-I      intronic chr5:172510027(+) A-I      intronic chr5:172509862(+) A-I      intronic chr5:172509861(+) A-I      intronic chr5:172509724(+) A-I      intronic chr5:172509701(+) A-I      intronic chr5:172509048(+) A-I      intronic chr5:172508808(+) A-I      intronic chr5:172508802(+) A-I      intronic chr5:172504593(+) A-I      intronic chr5:172504579(+) A-I      intronic chr5:172504521(+) A-I      intronic chr5:172504113(+) A-I      intronic chr5:172504112(+) A-I      intronic chr5:172504108(+) A-I      intronic chr5:172504086(+) A-I      intronic chr5:172504077(+) A-I      intronic chr5:172504076(+) A-I      intronic chr5:172504072(+) A-I      intronic chr5:172503997(+) A-I      intronic chr5:172503594(+) A-I      intronic chr5:172503578(+) A-I      intronic chr5:172503570(+) A-I      intronic chr5:172503558(+) A-I      intronic chr5:172502995(+) A-I      intronic chr5:172502974(+) A-I      intronic chr5:172501886(+) A-I      intronic chr5:172501768(+) A-I      intronic chr5:172501096(+) A-I      intronic chr5:172500721(+) A-I      intronic chr5:172499631(+) A-I      intronic chr5:172498803(+) A-I      intronic chr5:172498456(+) A-I      intronic chr5:172497130(+) A-I      intronic chr5:172497096(+) A-I      intronic chr5:172497060(+) A-I      intronic chr5:172497059(+) A-I      intronic chr5:172496444(+) A-I      intronic chr5:172495981(+) A-I      intronic chr5:172495977(+) A-I      intronic chr5:172495968(+) A-I      intronic chr5:172495964(+) A-I      intronic chr5:172495873(+) A-I      intronic chr5:172495862(+) A-I      intronic chr5:172495843(+) A-I      intronic chr5:172494991(+) A-I      intronic chr5:172494882(+) A-I      intronic chr5:172494825(+) A-I      intronic chr5:172491895(+) A-I      intronic chr5:172491490(+) A-I      intronic chr5:172491487(+) A-I      intronic chr5:172487514(+) A-I      intronic chr5:172556968(+) A-I      intronic chr5:172501174(+) A-I      intronic chr5:172501184(+) A-I      intronic chr5:172501185(+) A-I      intronic chr5:172501210(+) A-I      intronic chr5:172501216(+) A-I      intronic chr5:172506346(+) A-I      intronic chr5:172506355(+) A-I      intronic chr5:172506372(+) A-I      intronic chr5:172506378(+) A-I      intronic chr5:172506381(+) A-I      intronic chr5:172506391(+) A-I      intronic chr5:172508812(+) A-I      intronic chr5:172508819(+) A-I      intronic chr5:172508825(+) A-I      intronic chr5:172508827(+) A-I      intronic chr5:172516121(+) A-I      intronic chr5:172516129(+) A-I      intronic chr5:172516130(+) A-I      intronic chr5:172516140(+) A-I      intronic chr5:172552792(+) A-I      intronic chr5:172552817(+) A-I      intronic chr5:172552851(+) A-I      intronic chr5:172557073(+) A-I      intronic chr5:172557048(+) A-I      intronic chr5:172557025(+) A-I      intronic chr5:172557013(+) A-I      intronic chr5:172508721(+) A-I      intronic chr5:172556673(+) A-I      intronic chr5:172556585(+) A-I      intronic chr5:172556571(+) A-I      intronic chr5:172556567(+) A-I      intronic chr5:172556560(+) A-I      intronic chr5:172554713(+) A-I      intronic chr5:172554708(+) A-I      intronic chr5:172554692(+) A-I      intronic chr5:172554691(+) A-I      intronic chr5:172554683(+) A-I      intronic chr5:172554482(+) A-I      intronic chr5:172552806(+) A-I      intronic chr5:172552773(+) A-I      intronic chr5:172552769(+) A-I      intronic chr5:172552639(+) A-I      intronic chr5:172551305(+) A-I      intronic chr5:172544840(+) A-I      intronic chr5:172544831(+) A-I      intronic chr5:172544807(+) A-I      intronic chr5:172544302(+) A-I      intronic chr5:172544200(+) A-I      intronic chr5:172544198(+) A-I      intronic chr5:172538504(+) A-I      intronic chr5:172534935(+) A-I      intronic chr5:172534850(+) A-I      intronic chr5:172534797(+) A-I      intronic chr5:172533882(+) A-I      intronic chr5:172533330(+) A-I      intronic chr5:172533322(+) A-I      intronic chr5:172533312(+) A-I      intronic chr5:172532719(+) A-I      intronic chr5:172532628(+) A-I      intronic chr5:172532499(+) A-I      intronic chr5:172532488(+) A-I      intronic chr5:172531576(+) A-I      intronic chr5:172531415(+) A-I      intronic chr5:172528089(+) A-I      intronic chr5:172520755(+) A-I      intronic chr5:172520741(+) A-I      intronic chr5:172520646(+) A-I      intronic chr5:172520645(+) A-I      intronic chr5:172518886(+) A-I      3'UTR chr5:172518885(+) A-I      3'UTR chr5:172494948(+) A-I      intronic chr5:172544236(+) A-I      intronic chr5:172499418(+) A-I      intronic chr5:172503512(+) A-I      intronic chr5:172557910(+) A-I      intronic chr5:172491901(+) A-I      intronic chr5:172531452(+) A-I      intronic chr5:172554602(+) A-I      intronic chr5:172490765(+) A-I      intronic chr5:172545833(+) A-I      intronic chr5:172544120(+) A-I      intronic chr5:172544126(+) A-I      intronic chr5:172504525(+) A-I      intronic chr5:172511922(+) A-I      intronic chr5:172510046(+) A-I      intronic chr5:172495817(+) A-I      intronic chr5:172495928(+) A-I      intronic chr5:172498993(+) A-I      intronic chr5:172501155(+) A-I      intronic chr5:172504457(+) A-I      intronic chr5:172496366(+) A-I      intronic chr5:172512209(+) A-I      intronic chr5:172534704(+) A-I      intronic chr5:172532588(+) A-I      intronic chr5:172556678(+) A-I      intronic chr5:172556581(+) A-I      intronic chr5:172556929(+) A-I      intronic chr5:172509672(+) A-I      intronic chr5:172497037(+) A-I      intronic chr5:172509991(+) A-I      intronic chr5:172496378(+) A-I      intronic chr5:172544127(+) A-I      intronic chr5:172551430(+) A-I      intronic chr5:172504465(+) A-I      intronic chr5:172508747(+) A-I      intronic chr5:172496957(+) A-I      intronic chr5:172535087(+) A-I      intronic chr5:172504008(+) A-I      intronic chr5:172497105(+) A-I      intronic chr5:172508737(+) A-I      intronic chr5:172498881(+) A-I      intronic chr5:172494745(+) A-I      intronic chr5:172487990(+) A-I      intronic chr5:172532600(+) A-I      intronic chr5:172503609(+) A-I      intronic chr5:172504162(+) A-I      intronic chr5:172503709(+) A-I      intronic chr5:172528265(+) A-I      intronic chr5:172504024(+) A-I      intronic chr5:172503606(+) A-I      intronic chr5:172509829(+) A-I      intronic chr5:172512585(+) A-I      intronic chr5:172519041(+) A-I      3'UTR chr5:172518912(+) A-I      3'UTR chr5:172508654(+) A-I      intronic chr5:172533282(+) A-I      intronic chr5:172531500(+) A-I      intronic chr5:172504150(+) A-I      intronic chr5:172531521(+) A-I      intronic chr5:172551513(+) A-I      intronic chr5:172553409(+) A-I      intronic chr5:172501147(+) A-I      intronic chr5:172532651(+) A-I      intronic chr5:172508761(+) A-I      intronic chr5:172488110(+) A-I      intronic chr5:172499188(+) A-I      intronic chr5:172498872(+) A-I      intronic chr5:172528113(+) A-I      intronic chr5:172544298(+) A-I      intronic chr5:172553406(+) A-I      intronic chr5:172544110(+) A-I      intronic chr5:172504021(+) A-I      intronic chr5:172504216(+) A-I      intronic chr5:172496949(+) A-I      intronic chr5:172499161(+) A-I      intronic chr5:172509769(+) A-I      intronic chr5:172538411(+) A-I      intronic chr5:172556608(+) A-I      intronic chr5:172501904(+) A-I      intronic chr5:172514291(+) A-I      intronic chr5:172551411(+) A-I      intronic chr5:172491480(+) A-I      intronic chr5:172495954(+) A-I      intronic chr5:172557660(+) A-I      intronic chr5:172556677(+) A-I      intronic chr5:172496454(+) A-I      intronic chr5:172501081(+) A-I      intronic chr5:172504475(+) A-I      intronic chr5:172556467(+) A-I      intronic chr5:172503648(+) A-I      intronic chr5:172534852(+) A-I      intronic chr5:172509867(+) A-I      intronic chr5:172547567(+) A-I      intronic chr5:172528121(+) A-I      intronic chr5:172512586(+) A-I      intronic chr5:172509805(+) A-I      intronic chr5:172498825(+) A-I      intronic chr5:172498804(+) A-I      intronic chr5:172502969(+) A-I      intronic chr5:172494016(+) A-I      intronic chr5:172533898(+) A-I      intronic chr5:172556554(+) A-I      intronic chr5:172552972(+) A-I      intronic chr5:172534848(+) A-I      intronic chr5:172497027(+) A-I      intronic chr5:172534898(+) A-I      intronic chr5:172494803(+) A-I      intronic chr5:172504011(+) A-I      intronic chr5:172545964(+) A-I      intronic chr5:172499700(+) A-I      intronic chr5:172487495(+) A-I      intronic chr5:172556653(+) A-I      intronic chr5:172498937(+) A-I      intronic chr5:172501824(+) A-I      intronic chr5:172498954(+) A-I      intronic chr5:172510048(+) A-I      intronic chr5:172514130(+) A-I      intronic chr5:172553324(+) A-I      intronic chr5:172487462(+) A-I      intronic chr5:172551502(+) A-I      intronic chr5:172503704(+) A-I      intronic chr5:172503684(+) A-I      intronic chr5:172497143(+) A-I      intronic chr5:172496439(+) A-I      intronic chr5:172499420(+) A-I      intronic chr5:172509735(+) A-I      intronic chr5:172509725(+) A-I      intronic chr5:172494081(+) A-I      intronic chr5:172544268(+) A-I      intronic chr5:172512111(+) A-I      intronic chr5:172535044(+) A-I      intronic chr5:172553283(+) A-I      intronic chr5:172503592(+) A-I      intronic chr5:172505612(+) A-I      intronic chr5:172556539(+) A-I      intronic chr5:172503544(+) A-I      intronic chr5:172527049(+) A-I      intronic chr5:172556994(+) A-I      intronic chr5:172509791(+) A-I      intronic chr5:172494953(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CREBRF	chr5:172496431(+) A-I intron -    21960545 chr5:172499641(+) A-I intron -    21960545 chr5:172487462(+) A-G intron -    22484847 chr5:172487495(+) A-G intron -    22484847 chr5:172488069(+) T-C intron -    22484847 chr5:172490495(+) T-C intron -    22484847 chr5:172494016(+) A-G intron -    22484847 chr5:172494745(+) A-G intron -    22484847 chr5:172495928(+) A-G intron -    22484847 chr5:172496366(+) A-G intron -    22484847 chr5:172496378(+) A-G intron -    22484847 chr5:172496431(+) A-G intron -    22484847 chr5:172496439(+) A-G intron -    22484847 chr5:172496957(+) A-G intron -    22484847 chr5:172497015(+) A-G intron -    22484847 chr5:172497027(+) A-G intron -    22484847 chr5:172497037(+) A-G intron -    22484847 chr5:172497039(+) A-G intron -    22484847 chr5:172497131(+) A-G intron -    22484847 chr5:172497143(+) A-G intron -    22484847 chr5:172497158(+) A-G intron -    22484847 chr5:172499161(+) A-G intron -    22484847 chr5:172499188(+) A-G intron -    22484847 chr5:172499244(+) A-G intron -    22484847 chr5:172499632(+) A-G intron -    22484847 chr5:172499646(+) A-G intron -    22484847 chr5:172499652(+) A-G intron -    22484847 chr5:172501824(+) A-G intron -    22484847 chr5:172503544(+) A-G intron -    22484847 chr5:172503593(+) A-G intron -    22484847 chr5:172503609(+) A-G intron -    22484847 chr5:172503638(+) A-G intron -    22484847 chr5:172503648(+) A-G intron -    22484847 chr5:172503652(+) A-G intron -    22484847 chr5:172503704(+) A-G intron -    22484847 chr5:172503709(+) A-G intron -    22484847 chr5:172503716(+) A-G intron -    22484847 chr5:172504008(+) A-G intron -    22484847 chr5:172504011(+) A-G intron -    22484847 chr5:172504021(+) A-G intron -    22484847 chr5:172504024(+) A-G intron -    22484847 chr5:172504150(+) A-G intron -    22484847 chr5:172504162(+) A-G intron -    22484847 chr5:172504216(+) A-G intron -    22484847 chr5:172504475(+) A-G intron -    22484847 chr5:172504631(+) A-G intron -    22484847 chr5:172504648(+) A-G intron -    22484847 chr5:172508776(+) A-G intron -    22484847 chr5:172508803(+) A-G intron -    22484847 chr5:172508891(+) A-G intron -    22484847 chr5:172508894(+) A-G intron -    22484847 chr5:172518906(+) A-G intron -    22484847 chr5:172520772(+) A-G intron -    22484847 chr5:172532588(+) A-G intron -    22484847 chr5:172532654(+) A-G intron -    22484847 chr5:172533282(+) A-G intron -    22484847 chr5:172533892(+) A-G intron -    22484847 chr5:172533898(+) A-G intron -    22484847 chr5:172534704(+) A-G intron -    22484847 chr5:172552925(+) A-G intron -    22484847 chr5:172553934(+) A-G intron -    22484847 chr5:172553935(+) A-G intron -    22484847 chr5:172556929(+) A-G intron -    22484847 chr5:172556994(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CREBRF	chr5:172483374-172483375(+) m6A 5'UTR       24981863 chr5:172483388-172483389(+) m6A 5'UTR       24981863 chr5:172483394-172483395(+) m6A 5'UTR//exon       24981863 chr5:172483399-172483400(+) m6A 5'UTR//exon       24981863 chr5:172483445-172483446(+) m6A 5'UTR//exon       24981863 chr5:172483450-172483451(+) m6A 5'UTR//exon       24981863 chr5:172484349-172484350(+) m6A exon//intron       24981863 chr5:172484527-172484528(+) m6A 5'UTR//exon//intron       - chr5:172484586-172484587(+) m6A 5'UTR//exon//intron       - chr5:172484599-172484600(+) m6A 5'UTR//exon//intron       - chr5:172513597-172513598(+) m6A CDS//exon       22608085 chr5:172513625-172513626(+) m6A CDS//exon       22608085 chr5:172517330-172517331(+) m6A CDS//exon       22608085 chr5:172517351-172517352(+) m6A CDS//exon       24981863//22608085 chr5:172517372-172517373(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517381-172517382(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517441-172517442(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517448-172517449(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517471-172517472(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517490-172517491(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517515-172517516(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172517587-172517588(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr5:172517618-172517619(+) m6A CDS//exon       24284625//24981863//22608085 chr5:172517673-172517674(+) m6A CDS//exon       24284625//24981863//22608085 chr5:172517749-172517750(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517777-172517778(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517799-172517800(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517830-172517831(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517858-172517859(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517879-172517880(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr5:172517969-172517970(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172518000-172518001(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:172518064-172518065(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:172518072-172518073(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:172518222-172518223(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:172518284-172518285(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:172518315-172518316(+) m6A CDS//exon       24209618//25456834//24981863//26404942//27773535//22608085 chr5:172518341-172518342(+) m1A CDS//exon       26863196 chr5:172518399-172518400(+) m6A CDS//exon       24981863//27773535//22608085 chr5:172518431-172518432(+) m6A CDS//intron       27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	CREBRF	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: CREBRF

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).