Basic Information:

  VIRBase ID:  

HHID00005290

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          KLHL23:  NM_144711     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	KLHL23
miRBase Accession/Entrez ID	MIMAT0000458	151230
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DITHP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHL23	chr2:170560901(+) A-I      intronic chr2:170560869(+) A-I      intronic chr2:170560861(+) A-I      intronic chr2:170559714(+) A-I      intronic chr2:170559710(+) A-I      intronic chr2:170559695(+) A-I      intronic chr2:170559693(+) A-I      intronic chr2:170559692(+) A-I      intronic chr2:170559690(+) A-I      intronic chr2:170560897(+) A-I      intronic chr2:170559688(+) A-I      intronic chr2:170559671(+) A-I      intronic chr2:170559654(+) A-I      intronic chr2:170603727(+) A-I      intronic chr2:170603696(+) A-I      intronic chr2:170603670(+) A-I      intronic chr2:170601210(+) A-I      intronic chr2:170581346(+) A-I      intronic chr2:170581338(+) A-I      intronic chr2:170581327(+) A-I      intronic chr2:170581324(+) A-I      intronic chr2:170581321(+) A-I      intronic chr2:170566060(+) A-I      intronic chr2:170566055(+) A-I      intronic chr2:170559880(+) A-I      intronic chr2:170559834(+) A-I      intronic chr2:170558962(+) A-I      intronic chr2:170558961(+) A-I      intronic chr2:170559724(+) A-I      intronic chr2:170559725(+) A-I      intronic chr2:170559726(+) A-I      intronic chr2:170559729(+) A-I      intronic chr2:170560865(+) A-I      intronic chr2:170560968(+) A-I      intronic chr2:170560961(+) A-I      intronic chr2:170560945(+) A-I      intronic chr2:170560935(+) A-I      intronic chr2:170560934(+) A-I      intronic chr2:170560913(+) A-I      intronic chr2:170560911(+) A-I      intronic chr2:170601186(+) A-I      intronic chr2:170581926(+) A-I      intronic chr2:170581914(+) A-I      intronic chr2:170581913(+) A-I      intronic chr2:170577468(+) A-I      intronic chr2:170601636(+) A-I      intronic chr2:170563068(+) A-I      intronic chr2:170562045(+) A-I      intronic chr2:170560065(+) A-I      intronic chr2:170560053(+) A-I      intronic chr2:170559021(+) A-I      intronic chr2:170558975(+) A-I      intronic chr2:170558935(+) A-I      intronic chr2:170558898(+) A-I      intronic chr2:170601540(+) A-I      intronic chr2:170601834(+) A-I      intronic chr2:170601835(+) A-I      intronic chr2:170601850(+) A-I      intronic chr2:170563619(+) A-I      intronic chr2:170601876(+) A-I      intronic chr2:170601896(+) A-I      intronic chr2:170582390(+) A-I      intronic chr2:170601610(+) A-I      intronic chr2:170585478(+) A-I      intronic chr2:170586638(+) A-I      intronic chr2:170603695(+) A-I      intronic chr2:170603703(+) A-I      intronic chr2:170603801(+) A-I      intronic chr2:170601837(+) A-I      intronic chr2:170559858(+) A-I      intronic chr2:170559843(+) A-I      intronic chr2:170601902(+) A-I      intronic chr2:170566193(+) A-I      intronic chr2:170601187(+) A-I      intronic chr2:170562009(+) A-I      intronic chr2:170581886(+) A-I      intronic chr2:170563626(+) A-I      intronic chr2:170558876(+) A-I      intronic chr2:170562105(+) A-I      intronic chr2:170559852(+) A-I      intronic chr2:170603688(+) A-I      intronic chr2:170559002(+) A-I      intronic chr2:170558969(+) A-I      intronic chr2:170566217(+) A-I      intronic chr2:170601468(+) A-I      intronic chr2:170604378(+) A-I      intronic chr2:170601968(+) A-I      intronic chr2:170558928(+) A-I      intronic chr2:170601143(+) A-I      intronic chr2:170563511(+) A-I      intronic chr2:170577587(+) A-I      intronic chr2:170581881(+) A-I      intronic chr2:170582608(+) A-I      intronic chr2:170594176(+) A-I      intronic chr2:170601194(+) A-I      intronic chr2:170604394(+) A-I      intronic chr2:170561900(+) A-I      intronic chr2:170603802(+) A-I      intronic chr2:170566082(+) A-I      intronic chr2:170562110(+) A-I      intronic chr2:170566025(+) A-I      intronic chr2:170566020(+) A-I      intronic chr2:170566059(+) A-I      intronic chr2:170601208(+) A-I      intronic chr2:170577459(+) A-I      intronic chr2:170566085(+) A-I      intronic chr2:170587199(+) A-I      intronic chr2:170604511(+) A-I      intronic chr2:170601319(+) A-I      intronic chr2:170558884(+) A-I      intronic chr2:170565983(+) A-I      intronic chr2:170604076(+) A-I      intronic chr2:170566226(+) A-I      intronic chr2:170603671(+) A-I      intronic chr2:170601289(+) A-I      intronic chr2:170601249(+) A-I      intronic chr2:170558903(+) A-I      intronic chr2:170566179(+) A-I      intronic chr2:170578282(+) A-I      intronic chr2:170566097(+) A-I      intronic chr2:170560098(+) A-I      intronic chr2:170559835(+) A-I      intronic chr2:170560072(+) A-I      intronic chr2:170566067(+) A-I      intronic chr2:170583459(+) A-I      intronic chr2:170559828(+) A-I      intronic chr2:170603763(+) A-I      intronic chr2:170563319(+) A-I      intronic chr2:170603754(+) A-I      intronic chr2:170558976(+) A-I      intronic chr2:170601198(+) A-I      intronic chr2:170578288(+) A-I      intronic chr2:170604549(+) A-I      intronic chr2:170563107(+) A-I      intronic chr2:170601162(+) A-I      intronic chr2:170559813(+) A-I      intronic chr2:170601274(+) A-I      intronic chr2:170566103(+) A-I      intronic chr2:170559015(+) A-I      intronic chr2:170560093(+) A-I      intronic chr2:170604026(+) A-I      intronic chr2:170601266(+) A-I      intronic chr2:170560111(+) A-I      intronic chr2:170596719(+) A-I      intronic chr2:170604377(+) A-I      intronic chr2:170604064(+) A-I      intronic chr2:170581778(+) A-I      intronic chr2:170566081(+) A-I      intronic chr2:170577581(+) A-I      intronic chr2:170562058(+) A-I      intronic chr2:170603759(+) A-I      intronic chr2:170601203(+) A-I      intronic chr2:170589310(+) A-I      intronic chr2:170562041(+) A-I      intronic chr2:170585318(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHL23	chr2:170551077-170551078(+) m6A 5'UTR       25456834//24981863//22608085 chr2:170551082-170551083(+) m6A 5'UTR       25456834//24981863//22608085 chr2:170551127-170551128(+) m6A 5'UTR       25456834//24981863 chr2:170553949-170553950(+) m6A 5'UTR       24209618 chr2:170553969-170553970(+) m6A 5'UTR       24209618 chr2:170554463-170554464(+) m6A 5'UTR//intron       25456834 chr2:170557478-170557479(+) m6A intron       22608085 chr2:170557582-170557583(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:170557613-170557614(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:170557666-170557667(+) m6A intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:170557720-170557721(+) m6A intron       24284625//24209618//24981863//22608085 chr2:170590400-170590401(+) m6A 5'UTR//intron       25456834//24981863 chr2:170590444-170590445(+) m6A 5'UTR//intron       25456834//24981863 chr2:170591538-170591539(+) m6A CDS//intron       24981863//22608085 chr2:170591605-170591606(+) m6A CDS//intron       24284625//24981863//26404942//22608085 chr2:170591760-170591761(+) m6A CDS//intron       24284625//24981863//22608085 chr2:170591982-170591983(+) m6A CDS//intron       24981863//22608085 chr2:170592145-170592146(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr2:170592232-170592233(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr2:170592480-170592481(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr2:170592571-170592572(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr2:170592725-170592726(+) m6A CDS//intron       24209618//22608085 chr2:170605983-170605984(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr2:170606016-170606017(+) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//22608085 chr2:170608096-170608097(+) m6A 3'UTR//intron       27773535 chr2:170608168-170608169(+) m6A 3'UTR//intron       27773535 chr2:170608183-170608184(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	KLHL23	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: KLHL23

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).