Basic Information:

  VIRBase ID:  

HHID00005276

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          CAPN12:  NM_144691     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	CAPN12
miRBase Accession/Entrez ID	MIMAT0000458	147968
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAPN12	chr19:39231378(-) A-I      intronic chr19:39223061(-) A-I      intronic chr19:39223078(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAPN12	chr19:39229969(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAPN12	chr19:39220976-39220977(-) m6A 3'UTR       26404942//27773535//22575960 chr19:39220993-39220994(-) m6A 3'UTR       26404942//27773535//22575960 chr19:39221054-39221055(-) m6A 3'UTR       27773535 chr19:39221083-39221084(-) m6A 3'UTR       27773535 chr19:39221110-39221111(-) m6A 3'UTR//exon       27773535//27371828 chr19:39221210-39221211(-) m6A 3'UTR//exon       27773535//27371828 chr19:39221250-39221251(-) m6A 3'UTR//exon       27773535//27371828 chr19:39221307-39221308(-) m6A 3'UTR//exon       27773535 chr19:39221313-39221314(-) m6A 3'UTR//exon       27773535 chr19:39221607-39221608(-) m6A 3'UTR//CDS//exon       27371828 chr19:39221793-39221794(-) m6A 3'UTR//CDS//exon       27773535//27371828 chr19:39221833-39221834(-) m6A 3'UTR//CDS//exon       27773535//27371828 chr19:39221850-39221851(-) m6A 3'UTR//CDS//exon       27773535//27371828 chr19:39226219-39226220(-) m6A exon//intron       24981863 chr19:39226250-39226251(-) m6A exon//intron       27773535 chr19:39226274-39226275(-) m6A exon//intron       24981863//27773535 chr19:39227261-39227262(-) m6A exon//intron       27773535 chr19:39227303-39227304(-) m1A exon//intron       26863196 chr19:39227344-39227345(-) m6A exon//intron       27773535 chr19:39227425-39227426(-) m6A exon//intron       25456834//27773535 chr19:39227461-39227462(-) m6A exon//intron       25456834//27773535 chr19:39227481-39227482(-) m6A exon//intron       25456834 chr19:39227485-39227486(-) m6A exon//intron       25456834//27773535 chr19:39228016-39228017(-) m6A CDS       - chr19:39228025-39228026(-) m6A CDS       - chr19:39228263-39228264(-) m6A CDS       25456834 chr19:39228972-39228973(-) m6A CDS       25456834 chr19:39229099-39229100(-) m6A CDS       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	CAPN12	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: CAPN12

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).