Basic Information:

  VIRBase ID:  

HHID00005272

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          RTN4RL1:  NM_178568     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	RTN4RL1
miRBase Accession/Entrez ID	MIMAT0000458	146760
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NgR3//NGRH2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RTN4RL1	chr17:1868584(-) A-I      intronic chr17:1868625(-) A-I      intronic chr17:1868624(-) A-I      intronic chr17:1868588(-) A-I      intronic chr17:1847888(-) A-I      intronic chr17:1873363(-) A-I      intronic chr17:1856921(-) A-I      intronic chr17:1903880(-) A-I      intronic chr17:1868150(-) A-I      intronic chr17:1885822(-) A-I      intronic chr17:1882623(-) A-I      intronic chr17:1867224(-) A-I      intronic chr17:1886621(-) A-I      intronic chr17:1856136(-) A-I      intronic chr17:1856664(-) A-I      intronic chr17:1916344(-) A-I      intronic chr17:1913967(-) A-I      intronic chr17:1855720(-) A-I      intronic chr17:1925696(-) A-I      intronic chr17:1873358(-) A-I      intronic chr17:1868193(-) A-I      intronic chr17:1886519(-) A-I      intronic chr17:1868207(-) A-I      intronic chr17:1925062(-) A-I      intronic chr17:1913949(-) A-I      intronic chr17:1882362(-) A-I      intronic chr17:1916226(-) A-I      intronic chr17:1925391(-) A-I      intronic chr17:1862913(-) A-I      intronic chr17:1913927(-) A-I      intronic chr17:1908957(-) A-I      intronic chr17:1855706(-) A-I      intronic chr17:1913944(-) A-I      intronic chr17:1904070(-) A-I      intronic chr17:1907473(-) A-I      intronic chr17:1895445(-) A-I      intronic chr17:1914506(-) A-I      intronic chr17:1872424(-) A-I      intronic chr17:1896280(-) A-I      intronic chr17:1866343(-) A-I      intronic chr17:1908931(-) A-I      intronic chr17:1916320(-) A-I      intronic chr17:1910100(-) A-I      intronic chr17:1886972(-) A-I      intronic chr17:1908547(-) A-I      intronic chr17:1904676(-) A-I      intronic chr17:1916228(-) A-I      intronic chr17:1872580(-) A-I      intronic chr17:1876564(-) A-I      intronic chr17:1876548(-) A-I      intronic chr17:1925713(-) A-I      intronic chr17:1909187(-) A-I      intronic chr17:1886586(-) A-I      intronic chr17:1913984(-) A-I      intronic chr17:1909980(-) A-I      intronic chr17:1908926(-) A-I      intronic chr17:1856249(-) A-I      intronic chr17:1873383(-) A-I      intronic chr17:1873528(-) A-I      intronic chr17:1913990(-) A-I      intronic chr17:1841736(-) A-I      intronic chr17:1908886(-) A-I      intronic chr17:1884634(-) A-I      intronic chr17:1873316(-) A-I      intronic chr17:1858669(-) A-I      intronic chr17:1882636(-) A-I      intronic chr17:1854779(-) A-I      intronic chr17:1885431(-) A-I      intronic chr17:1868337(-) A-I      intronic chr17:1883460(-) A-I      intronic chr17:1913671(-) A-I      intronic chr17:1924987(-) A-I      intronic chr17:1861431(-) A-I      intronic chr17:1883486(-) A-I      intronic chr17:1886833(-) A-I      intronic chr17:1854019(-) A-I      intronic chr17:1925719(-) A-I      intronic chr17:1903736(-) A-I      intronic chr17:1858632(-) A-I      intronic chr17:1914147(-) A-I      intronic chr17:1907120(-) A-I      intronic chr17:1925741(-) A-I      intronic chr17:1856996(-) A-I      intronic chr17:1886477(-) A-I      intronic chr17:1886412(-) A-I      intronic chr17:1868469(-) A-I      intronic chr17:1858652(-) A-I      intronic chr17:1868221(-) A-I      intronic chr17:1882688(-) A-I      intronic chr17:1860207(-) A-I      intronic chr17:1858647(-) A-I      intronic chr17:1916216(-) A-I      intronic chr17:1911500(-) A-I      intronic chr17:1858750(-) A-I      intronic chr17:1858844(-) A-I      intronic chr17:1876422(-) A-I      intronic chr17:1913506(-) A-I      intronic chr17:1883564(-) A-I      intronic chr17:1892922(-) A-I      intronic chr17:1893900(-) A-I      intronic chr17:1857041(-) A-I      intronic chr17:1910125(-) A-I      intronic chr17:1867215(-) A-I      intronic chr17:1866074(-) A-I      intronic chr17:1914080(-) A-I      intronic chr17:1868276(-) A-I      intronic chr17:1841843(-) A-I      intronic chr17:1908944(-) A-I      intronic chr17:1908964(-) A-I      intronic chr17:1908392(-) A-I      intronic chr17:1841733(-) A-I      intronic chr17:1883611(-) A-I      intronic chr17:1875596(-) A-I      intronic chr17:1913649(-) A-I      intronic chr17:1916261(-) A-I      intronic chr17:1882719(-) A-I      intronic chr17:1876534(-) A-I      intronic chr17:1842100(-) A-I      intronic chr17:1908368(-) A-I      intronic chr17:1902628(-) A-I      intronic chr17:1882749(-) A-I      intronic chr17:1868594(-) A-I      intronic chr17:1925042(-) A-I      intronic chr17:1908438(-) A-I      intronic chr17:1866324(-) A-I      intronic chr17:1866244(-) A-I      intronic chr17:1885548(-) A-I      intronic chr17:1841734(-) A-I      intronic chr17:1867616(-) A-I      intronic chr17:1865914(-) A-I      intronic chr17:1908914(-) A-I      intronic chr17:1886892(-) A-I      intronic chr17:1925718(-) A-I      intronic chr17:1876704(-) A-I      intronic chr17:1914141(-) A-I      intronic chr17:1864977(-) A-I      intronic chr17:1908902(-) A-I      intronic chr17:1866062(-) A-I      intronic chr17:1887774(-) A-I      intronic chr17:1871032(-) A-I      intronic chr17:1885543(-) A-I      intronic chr17:1842196(-) A-I      intronic chr17:1865760(-) A-I      intronic chr17:1871030(-) A-I      intronic chr17:1912606(-) A-I      intronic chr17:1886504(-) A-I      intronic chr17:1925673(-) A-I      intronic chr17:1842179(-) A-I      intronic chr17:1876400(-) A-I      intronic chr17:1884669(-) A-I      intronic chr17:1882765(-) A-I      intronic chr17:1876726(-) A-I      intronic chr17:1892964(-) A-I      intronic chr17:1908556(-) A-I      intronic chr17:1907154(-) A-I      intronic chr17:1908574(-) A-I      intronic chr17:1919412(-) A-I      intronic chr17:1842088(-) A-I      intronic chr17:1867203(-) A-I      intronic chr17:1893976(-) A-I      intronic chr17:1916315(-) A-I      intronic chr17:1856654(-) A-I      intronic chr17:1912537(-) A-I      intronic chr17:1865203(-) A-I      intronic chr17:1883327(-) A-I      intronic chr17:1864965(-) A-I      intronic chr17:1908974(-) A-I      intronic chr17:1862997(-) A-I      intronic chr17:1924372(-) A-I      intronic chr17:1903501(-) A-I      intronic chr17:1883496(-) A-I      intronic chr17:1875544(-) A-I      intronic chr17:1871207(-) A-I      intronic chr17:1883582(-) A-I      intronic chr17:1892410(-) A-I      intronic chr17:1886417(-) A-I      intronic chr17:1913708(-) A-I      intronic chr17:1881885(-) A-I      intronic chr17:1885637(-) A-I      intronic chr17:1866356(-) A-I      intronic chr17:1916170(-) A-I      intronic chr17:1909728(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RTN4RL1	chr17:1838156-1838157(-) m6A 3'UTR       25456834//27371828 chr17:1838176-1838177(-) m6A 3'UTR       25456834//27371828 chr17:1838197-1838198(-) m6A 3'UTR       25456834//27371828 chr17:1838258-1838259(-) m6A 3'UTR       25456834//27371828 chr17:1838288-1838289(-) m6A 3'UTR       27371828 chr17:1838541-1838542(-) m6A 3'UTR       27773535 chr17:1838828-1838829(-) m6A 3'UTR       25456834//27773535//22608085 chr17:1838852-1838853(-) m6A 3'UTR       25456834//27773535//22608085 chr17:1838885-1838886(-) m6A 3'UTR       25456834//27773535//22608085 chr17:1838917-1838918(-) m6A 3'UTR       27773535 chr17:1838931-1838932(-) m6A 3'UTR       27773535 chr17:1838943-1838944(-) m6A 3'UTR       27773535 chr17:1839129-1839130(-) m6A 3'UTR       24284625//27773535 chr17:1839171-1839172(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839199-1839200(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839377-1839378(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1839480-1839481(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1839545-1839546(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1839626-1839627(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839647-1839648(-) m6A 3'UTR       24284625//24981863//27773535//27371828//22608085 chr17:1839742-1839743(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085 chr17:1839786-1839787(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085 chr17:1839818-1839819(-) m6A CDS       24284625//25456834//24981863//27371828//22608085 chr17:1839893-1839894(-) m6A CDS       24284625//25456834//24981863//27371828//22608085 chr17:1839967-1839968(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1839979-1839980(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1839999-1840000(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr17:1840033-1840034(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:1840051-1840052(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:1840131-1840132(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840197-1840198(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840207-1840208(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840216-1840217(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840240-1840241(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085 chr17:1840342-1840343(-) m6A CDS       24284625//25456834//27371828//22608085 chr17:1840495-1840496(-) m6A CDS       24284625//27371828 chr17:1840516-1840517(-) m6A CDS       27371828 chr17:1840522-1840523(-) m6A CDS       27371828 chr17:1840757-1840758(-) m6A CDS       27371828 chr17:1840798-1840799(-) m6A CDS       27371828 chr17:1840858-1840859(-) m6A CDS       27371828 chr17:1840927-1840928(-) m6A CDS       27371828 chr17:1840951-1840952(-) m6A CDS       27371828 chr17:1841032-1841033(-) m6A CDS       24284625//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	RTN4RL1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: RTN4RL1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).