Basic Information:

  VIRBase ID:  

HHID00005268

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PRIMA1:  NM_178013     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PRIMA1
miRBase Accession/Entrez ID	MIMAT0000458	145270
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRIMA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRIMA1	chr14:94224869(-) A-I      intronic chr14:94243791(-) A-I      intronic chr14:94191495(-) A-I      intronic chr14:94193785(-) A-I      intronic chr14:94243820(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRIMA1	chr14:94186976-94186977(-) m6A 3'UTR       25456834//24981863 chr14:94187004-94187005(-) m6A 3'UTR       25456834//24981863 chr14:94187058-94187059(-) m6A 3'UTR       25456834//24981863 chr14:94187122-94187123(-) m6A 3'UTR       25456834//24981863 chr14:94187595-94187596(-) m6A 3'UTR       25456834//24981863//27773536 chr14:94187649-94187650(-) m6A 3'UTR       25456834//24981863 chr14:94187689-94187690(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187717-94187718(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187735-94187736(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187756-94187757(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187773-94187774(-) m6A 3'UTR       25456834//24981863//22608085 chr14:94187805-94187806(-) m6A 3'UTR//CDS       25456834//24981863//22608085 chr14:94187888-94187889(-) m6A 3'UTR//CDS       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	PRIMA1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PRIMA1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).