Basic Information:

  VIRBase ID:  

HHID00005255

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          TRPM6:  NM_017662     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	TRPM6
miRBase Accession/Entrez ID	MIMAT0000458	140803
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHAK2//HMGX//HOMG//HOMG1//HSH

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRPM6	chr9:77384226(-) A-I      intronic chr9:77384194(-) A-I      intronic chr9:77384186(-) A-I      intronic chr9:77347940(-) A-I      intronic chr9:77433456(-) A-I      intronic chr9:77433315(-) A-I      intronic chr9:77361020(-) A-I      intronic chr9:77348707(-) A-I      intronic chr9:77467008(-) A-I      intronic chr9:77445633(-) A-I      intronic chr9:77384154(-) A-I      intronic chr9:77348613(-) A-I      intronic chr9:77384268(-) A-I      intronic chr9:77350014(-) A-I      intronic chr9:77408374(-) A-I      intronic chr9:77416245(-) A-I      intronic chr9:77445409(-) A-I      intronic chr9:77445479(-) A-I      intronic chr9:77443709(-) A-I      intronic chr9:77348706(-) A-I      intronic chr9:77401609(-) A-I      intronic chr9:77347947(-) A-I      intronic chr9:77348668(-) A-I      intronic chr9:77408383(-) A-I      intronic chr9:77480793(-) A-I      intronic chr9:77347944(-) A-I      intronic chr9:77443642(-) A-I      intronic chr9:77478664(-) A-I      intronic chr9:77443683(-) A-I      intronic chr9:77348730(-) A-I      intronic chr9:77408373(-) A-I      intronic chr9:77384200(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRPM6	chr9:77377633(-) A-I exon CDS    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRPM6	chr9:77339230-77339231(-) m6A 3'UTR       24981863//27773535 chr9:77339351-77339352(-) m6A 3'UTR       24981863 chr9:77339423-77339424(-) m6A 3'UTR       24981863 chr9:77339481-77339482(-) m6A 3'UTR       24981863//27773535 chr9:77339612-77339613(-) m6A CDS       24981863//27773535 chr9:77343161-77343162(-) m6A CDS       24981863 chr9:77377021-77377022(-) m6A CDS       24981863 chr9:77377038-77377039(-) m6A CDS       24981863 chr9:77377099-77377100(-) m6A CDS       24981863//27773535//22608085 chr9:77377122-77377123(-) m6A CDS       24981863//27773535//22608085 chr9:77377166-77377167(-) m6A CDS       24981863//27773535 chr9:77377199-77377200(-) m6A CDS       24981863//27773535 chr9:77377225-77377226(-) m6A CDS       24981863//27773535//22608085 chr9:77377244-77377245(-) m6A CDS       24981863//27773535//22608085 chr9:77377290-77377291(-) m6A CDS       24981863//27773535//22608085 chr9:77377333-77377334(-) m6A CDS       25456834//24981863//27773535//22608085 chr9:77377338-77377339(-) m6A CDS       25456834//24981863//27773535//22608085 chr9:77377380-77377381(-) m6A CDS       25456834//24981863//27773535//22608085 chr9:77377415-77377416(-) m6A CDS       25456834//24981863//27773535 chr9:77377445-77377446(-) m6A CDS       25456834//24981863//27773535 chr9:77377453-77377454(-) m6A CDS       25456834//24981863//27773535 chr9:77377458-77377459(-) m6A CDS       25456834//24981863//27773535 chr9:77377488-77377489(-) m6A CDS       25456834//24981863 chr9:77377508-77377509(-) m6A CDS       24981863 chr9:77377622-77377623(-) m6A CDS       24981863 chr9:77377672-77377673(-) m6A CDS       24981863 chr9:77377842-77377843(-) m6A CDS       24981863 chr9:77377959-77377960(-) m6A CDS       24981863 chr9:77377972-77377973(-) m6A CDS       24981863 chr9:77377990-77377991(-) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	TRPM6	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Membrane K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: TRPM6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).