Basic Information:

  VIRBase ID:  

HHID00005200

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          FGD4:  NM_001384132     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	FGD4
miRBase Accession/Entrez ID	MIMAT0000458	121512
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CMT4H//FRABP//ZFYVE6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FGD4	chr12:32703533(+) A-I      intronic chr12:32703520(+) A-I      intronic chr12:32691913(+) A-I      intronic chr12:32691909(+) A-I      intronic chr12:32691908(+) A-I      intronic chr12:32691894(+) A-I      intronic chr12:32691881(+) A-I      intronic chr12:32691877(+) A-I      intronic chr12:32763382(+) A-I      intronic chr12:32798453(+) A-I      3'UTR chr12:32763379(+) A-I      intronic chr12:32798472(+) A-I      3'UTR chr12:32763381(+) A-I      intronic chr12:32798477(+) A-I      3'UTR chr12:32798518(+) A-I      3'UTR chr12:32763354(+) A-I      intronic chr12:32763345(+) A-I      intronic chr12:32763335(+) A-I      intronic chr12:32747915(+) A-I      intronic chr12:32760290(+) A-I      intronic chr12:32760548(+) A-I      intronic chr12:32673450(+) A-I      intronic chr12:32731375(+) A-I      intronic chr12:32731373(+) A-I      intronic chr12:32731372(+) A-I      intronic chr12:32706836(+) A-I      intronic chr12:32726236(+) A-I      intronic chr12:32731509(+) A-I      intronic chr12:32731614(+) A-I      intronic chr12:32740554(+) A-I      intronic chr12:32740547(+) A-I      intronic chr12:32740466(+) A-I      intronic chr12:32740418(+) A-I      intronic chr12:32797973(+) A-I      3'UTR chr12:32798463(+) A-I      3'UTR chr12:32724334(+) A-I      intronic chr12:32691867(+) A-I      intronic chr12:32723125(+) A-I      intronic chr12:32691873(+) A-I      intronic chr12:32723120(+) A-I      intronic chr12:32723116(+) A-I      intronic chr12:32723096(+) A-I      intronic chr12:32723087(+) A-I      intronic chr12:32723081(+) A-I      intronic chr12:32723064(+) A-I      intronic chr12:32703559(+) A-I      intronic chr12:32703546(+) A-I      intronic chr12:32697244(+) A-I      intronic chr12:32697296(+) A-I      intronic chr12:32786818(+) A-I      intronic chr12:32786801(+) A-I      intronic chr12:32697314(+) A-I      intronic chr12:32697560(+) A-I      intronic chr12:32740508(+) A-I      intronic chr12:32784543(+) A-I      intronic chr12:32784539(+) A-I      intronic chr12:32740534(+) A-I      intronic chr12:32697647(+) A-I      intronic chr12:32743103(+) A-I      intronic chr12:32760537(+) A-I      intronic chr12:32760274(+) A-I      intronic chr12:32700299(+) A-I      intronic chr12:32700860(+) A-I      intronic chr12:32760232(+) A-I      intronic chr12:32700908(+) A-I      intronic chr12:32743111(+) A-I      intronic chr12:32743119(+) A-I      intronic chr12:32703592(+) A-I      intronic chr12:32784519(+) A-I      intronic chr12:32706919(+) A-I      intronic chr12:32708610(+) A-I      intronic chr12:32784503(+) A-I      intronic chr12:32745117(+) A-I      intronic chr12:32723452(+) A-I      intronic chr12:32783720(+) A-I      intronic chr12:32723456(+) A-I      intronic chr12:32723462(+) A-I      intronic chr12:32723469(+) A-I      intronic chr12:32723609(+) A-I      intronic chr12:32783702(+) A-I      intronic chr12:32723618(+) A-I      intronic chr12:32724210(+) A-I      intronic chr12:32750896(+) A-I      intronic chr12:32724211(+) A-I      intronic chr12:32754839(+) A-I      intronic chr12:32724242(+) A-I      intronic chr12:32783691(+) A-I      intronic chr12:32724243(+) A-I      intronic chr12:32724304(+) A-I      intronic chr12:32724309(+) A-I      intronic chr12:32783656(+) A-I      intronic chr12:32724317(+) A-I      intronic chr12:32774108(+) A-I      intronic chr12:32724924(+) A-I      intronic chr12:32724956(+) A-I      intronic chr12:32731605(+) A-I      intronic chr12:32731606(+) A-I      intronic chr12:32754840(+) A-I      intronic chr12:32731608(+) A-I      intronic chr12:32732042(+) A-I      intronic chr12:32732055(+) A-I      intronic chr12:32760632(+) A-I      intronic chr12:32732127(+) A-I      intronic chr12:32732164(+) A-I      intronic chr12:32760629(+) A-I      intronic chr12:32732212(+) A-I      intronic chr12:32732240(+) A-I      intronic chr12:32737976(+) A-I      intronic chr12:32760588(+) A-I      intronic chr12:32754928(+) A-I      intronic chr12:32738081(+) A-I      intronic chr12:32738793(+) A-I      intronic chr12:32739905(+) A-I      intronic chr12:32739929(+) A-I      intronic chr12:32739948(+) A-I      intronic chr12:32760547(+) A-I      intronic chr12:32739954(+) A-I      intronic chr12:32739966(+) A-I      intronic chr12:32760544(+) A-I      intronic chr12:32740081(+) A-I      intronic chr12:32740094(+) A-I      intronic chr12:32740499(+) A-I      intronic chr12:32667469(+) A-I      intronic chr12:32667549(+) A-I      intronic chr12:32667886(+) A-I      intronic chr12:32667903(+) A-I      intronic chr12:32790409(+) A-I      intronic chr12:32787760(+) A-I      intronic chr12:32677271(+) A-I      intronic chr12:32677577(+) A-I      intronic chr12:32677620(+) A-I      intronic chr12:32682656(+) A-I      intronic chr12:32787714(+) A-I      intronic chr12:32682666(+) A-I      intronic chr12:32682670(+) A-I      intronic chr12:32754934(+) A-I      intronic chr12:32738794(+) A-I      intronic chr12:32665260(+) A-I      intronic chr12:32789320(+) A-I      intronic chr12:32786837(+) A-I      intronic chr12:32740429(+) A-I      intronic chr12:32737916(+) A-I      intronic chr12:32732050(+) A-I      intronic chr12:32738042(+) A-I      intronic chr12:32745060(+) A-I      intronic chr12:32738606(+) A-I      intronic chr12:32703456(+) A-I      intronic chr12:32669299(+) A-I      intronic chr12:32736137(+) A-I      intronic chr12:32774094(+) A-I      intronic chr12:32774054(+) A-I      intronic chr12:32786798(+) A-I      intronic chr12:32760280(+) A-I      intronic chr12:32737993(+) A-I      intronic chr12:32778356(+) A-I      intronic chr12:32786757(+) A-I      intronic chr12:32672035(+) A-I      intronic chr12:32700718(+) A-I      intronic chr12:32740442(+) A-I      intronic chr12:32723048(+) A-I      intronic chr12:32740560(+) A-I      intronic chr12:32731715(+) A-I      intronic chr12:32738589(+) A-I      intronic chr12:32683369(+) A-I      intronic chr12:32745073(+) A-I      intronic chr12:32738647(+) A-I      intronic chr12:32750920(+) A-I      intronic chr12:32780287(+) A-I      intronic chr12:32731673(+) A-I      intronic chr12:32723061(+) A-I      intronic chr12:32798601(+) A-I      3'UTR chr12:32798575(+) A-I      3'UTR chr12:32798471(+) A-I      3'UTR chr12:32798574(+) A-I      3'UTR chr12:32756882(+) A-I      intronic chr12:32740411(+) A-I      intronic chr12:32665293(+) A-I      intronic chr12:32732147(+) A-I      intronic chr12:32709973(+) A-I      intronic chr12:32682630(+) A-I      intronic chr12:32774053(+) A-I      intronic chr12:32752743(+) A-I      intronic chr12:32683374(+) A-I      intronic chr12:32723597(+) A-I      intronic chr12:32781581(+) A-I      intronic chr12:32732037(+) A-I      intronic chr12:32740425(+) A-I      intronic chr12:32750963(+) A-I      intronic chr12:32788825(+) A-I      intronic chr12:32750934(+) A-I      intronic chr12:32783678(+) A-I      intronic chr12:32732252(+) A-I      intronic chr12:32774131(+) A-I      intronic chr12:32723013(+) A-I      intronic chr12:32731699(+) A-I      intronic chr12:32722999(+) A-I      intronic chr12:32781477(+) A-I      intronic chr12:32665261(+) A-I      intronic chr12:32691095(+) A-I      intronic chr12:32743086(+) A-I      intronic chr12:32745040(+) A-I      intronic chr12:32731617(+) A-I      intronic chr12:32724224(+) A-I      intronic chr12:32703490(+) A-I      intronic chr12:32740065(+) A-I      intronic chr12:32665333(+) A-I      intronic chr12:32684027(+) A-I      intronic chr12:32773806(+) A-I      intronic chr12:32732261(+) A-I      intronic chr12:32779862(+) A-I      intronic chr12:32781478(+) A-I      intronic chr12:32774047(+) A-I      intronic chr12:32697410(+) A-I      intronic chr12:32723399(+) A-I      intronic chr12:32669330(+) A-I      intronic chr12:32674142(+) A-I      intronic chr12:32723643(+) A-I      intronic chr12:32783531(+) A-I      intronic chr12:32667860(+) A-I      intronic chr12:32740428(+) A-I      intronic chr12:32786878(+) A-I      intronic chr12:32783532(+) A-I      intronic chr12:32724941(+) A-I      intronic chr12:32779838(+) A-I      intronic chr12:32790423(+) A-I      intronic chr12:32780362(+) A-I      intronic chr12:32664326(+) A-I      intronic chr12:32740424(+) A-I      intronic chr12:32723031(+) A-I      intronic chr12:32674249(+) A-I      intronic chr12:32731730(+) A-I      intronic chr12:32724268(+) A-I      intronic chr12:32783507(+) A-I      intronic chr12:32731413(+) A-I      intronic chr12:32740559(+) A-I      intronic chr12:32778378(+) A-I      intronic chr12:32699272(+) A-I      intronic chr12:32724352(+) A-I      intronic chr12:32738045(+) A-I      intronic chr12:32740577(+) A-I      intronic chr12:32709984(+) A-I      intronic chr12:32779121(+) A-I      intronic chr12:32779915(+) A-I      intronic chr12:32752413(+) A-I      intronic chr12:32681599(+) A-I      intronic chr12:32750860(+) A-I      intronic chr12:32783670(+) A-I      intronic chr12:32740402(+) A-I      intronic chr12:32731371(+) A-I      intronic chr12:32671990(+) A-I      intronic chr12:32667546(+) A-I      intronic chr12:32737945(+) A-I      intronic chr12:32731500(+) A-I      intronic chr12:32745146(+) A-I      intronic chr12:32705490(+) A-I      intronic chr12:32783529(+) A-I      intronic chr12:32775007(+) A-I      intronic chr12:32783869(+) A-I      intronic chr12:32774133(+) A-I      intronic chr12:32697489(+) A-I      intronic chr12:32703422(+) A-I      intronic chr12:32750924(+) A-I      intronic chr12:32731625(+) A-I      intronic chr12:32703419(+) A-I      intronic chr12:32774150(+) A-I      intronic chr12:32738728(+) A-I      intronic chr12:32722989(+) A-I      intronic chr12:32738009(+) A-I      intronic chr12:32783867(+) A-I      intronic chr12:32736160(+) A-I      intronic chr12:32773794(+) A-I      intronic chr12:32740490(+) A-I      intronic chr12:32724310(+) A-I      intronic chr12:32749748(+) A-I      intronic chr12:32667532(+) A-I      intronic chr12:32745182(+) A-I      intronic chr12:32731409(+) A-I      intronic chr12:32738688(+) A-I      intronic chr12:32723100(+) A-I      intronic chr12:32731530(+) A-I      intronic chr12:32709605(+) A-I      intronic chr12:32740017(+) A-I      intronic chr12:32760469(+) A-I      intronic chr12:32779306(+) A-I      intronic chr12:32739960(+) A-I      intronic chr12:32783494(+) A-I      intronic chr12:32781471(+) A-I      intronic chr12:32783341(+) A-I      intronic chr12:32732110(+) A-I      intronic chr12:32677504(+) A-I      intronic chr12:32783785(+) A-I      intronic chr12:32691094(+) A-I      intronic chr12:32732161(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FGD4	chr12:32730471(+) A-I intron -    21960545 chr12:32780199(+) C-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FGD4	chr12:32552638-32552639(+) m6A 5'UTR       25456834 chr12:32734937-32734938(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863//22608085 chr12:32734954-32734955(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:32734995-32734996(+) m6A 5'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735044-32735045(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:32735059-32735060(+) m6A 5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:32735093-32735094(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:32735160-32735161(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735203-32735204(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735234-32735235(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735272-32735273(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr12:32735320-32735321(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735326-32735327(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735367-32735368(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735381-32735382(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr12:32735413-32735414(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085 chr12:32735434-32735435(+) m6A 3'UTR//exon//intron       25456834//24981863 chr12:32793276-32793277(+) m6A 3'UTR//CDS       25456834//24981863//22608085 chr12:32793295-32793296(+) m6A 3'UTR//CDS       25456834//24981863//22608085 chr12:32793333-32793334(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr12:32793343-32793344(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr12:32793392-32793393(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//22608085 chr12:32793442-32793443(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//22608085 chr12:32793467-32793468(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793478-32793479(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793504-32793505(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793518-32793519(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr12:32793594-32793595(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr12:32793676-32793677(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	FGD4	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: FGD4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).