Detail Information

Basic Information:


  VIRBase ID:  

HHID00005192

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           LYSMD3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p LYSMD3
miRBase
Accession/Entrez ID		 MIMAT0000458 116068
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LYSMD3
chr5:89820968(-) A-I      NonSyn:Lys->Glu
chr5:89820969(-) A-I      Syn:Gly->Gly
chr5:89820966(-) A-I      Syn:Lys->Lys
chr5:89820681(-) A-I      intronic
chr5:89820682(-) A-I      intronic
chr5:89820477(-) A-I      intronic
chr5:89816480(-) A-I      intronic
chr5:89816624(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LYSMD3
chr5:89814162-89814163(-) m6A 3'UTR       27773535
chr5:89814239-89814240(-) m6A 3'UTR       27773535
chr5:89814640-89814641(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr5:89814683-89814684(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr5:89814792-89814793(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:89814898-89814899(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:89814918-89814919(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:89814936-89814937(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:89814951-89814952(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:89814965-89814966(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:89815014-89815015(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr5:89815029-89815030(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr5:89815049-89815050(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr5:89815056-89815057(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr5:89815062-89815063(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr5:89815136-89815137(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr5:89815175-89815176(-) m6A CDS//intron       24284625//24981863//27773535//27371828//22608085
chr5:89815198-89815199(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr5:89815257-89815258(-) m6A 3'UTR//CDS//intron       24284625//27773535//22608085
chr5:89816208-89816209(-) m6A 3'UTR//intron       27773535//22608085
chr5:89816233-89816234(-) m6A 3'UTR//intron       27773535//22608085
chr5:89820932-89820933(-) m6A CDS       24284625//24981863//27773535//22608085
chr5:89820983-89820984(-) m6A CDS       24981863//27773535//27371828//22608085
chr5:89821020-89821021(-) m6A CDS       24981863//27773535//27371828//22608085
chr5:89822761-89822762(-) m6A 5'UTR//intron       27773535//27371828
chr5:89822784-89822785(-) m6A 5'UTR//intron       27773535//27371828
chr5:89825267-89825268(-) m6A 5'UTR       24981863//27371828
chr5:89825310-89825311(-) m6A 5'UTR       24981863//27371828
chr5:89825326-89825327(-) m6A 5'UTR       24981863//27371828
chr5:89825337-89825338(-) m6A 5'UTR       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
LYSMD3
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: LYSMD3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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