Basic Information:

  VIRBase ID:  

HHID00005169

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          MYADM:  NM_001290194     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	MYADM
miRBase Accession/Entrez ID	MIMAT0000458	91663
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SB135

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MYADM	chr19:54379054(+) A-I      3'UTR chr19:54378889(+) A-I      3'UTR chr19:54378893(+) A-I      3'UTR chr19:54378901(+) A-I      3'UTR chr19:54378902(+) A-I      3'UTR chr19:54378938(+) A-I      3'UTR chr19:54379013(+) A-I      3'UTR chr19:54379061(+) A-I      3'UTR chr19:54378943(+) A-I      3'UTR chr19:54378950(+) A-I      3'UTR chr19:54378953(+) A-I      3'UTR chr19:54379016(+) A-I      3'UTR chr19:54379024(+) A-I      3'UTR chr19:54379025(+) A-I      3'UTR chr19:54379038(+) A-I      3'UTR chr19:54379045(+) A-I      3'UTR chr19:54379048(+) A-I      3'UTR chr19:54379049(+) A-I      3'UTR chr19:54379053(+) A-I      3'UTR chr19:54374378(+) A-I      intronic chr19:54374442(+) A-I      intronic chr19:54375697(+) A-I      intronic chr19:54375726(+) A-I      intronic chr19:54375854(+) A-I      intronic chr19:54375900(+) A-I      intronic chr19:54376578(+) A-I      intronic chr19:54374251(+) A-I      intronic chr19:54374265(+) A-I      intronic chr19:54374275(+) A-I      intronic chr19:54374343(+) A-I      intronic chr19:54374374(+) A-I      intronic chr19:54375295(+) A-I      intronic chr19:54376002(+) A-I      intronic chr19:54375873(+) A-I      intronic chr19:54375793(+) A-I      intronic chr19:54375878(+) A-I      intronic chr19:54375292(+) A-I      intronic chr19:54376576(+) A-I      intronic chr19:54376587(+) A-I      intronic chr19:54376546(+) A-I      intronic chr19:54375500(+) A-I      intronic chr19:54375579(+) A-I      intronic chr19:54376447(+) A-I      intronic chr19:54375964(+) A-I      intronic chr19:54374437(+) A-I      intronic chr19:54376547(+) A-I      intronic chr19:54376016(+) A-I      intronic chr19:54374391(+) A-I      intronic chr19:54376368(+) A-I      intronic chr19:54374207(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MYADM	chr19:54371138-54371139(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr19:54372689-54372690(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr19:54373085-54373086(+) m6A 5'UTR//intron       24284625//24981863 chr19:54377186-54377187(+) m6A CDS       24284625//24981863 chr19:54377254-54377255(+) m6A CDS       24284625//24981863 chr19:54377323-54377324(+) m6A CDS       24284625//24981863//22575960 chr19:54377453-54377454(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr19:54377654-54377655(+) m6A CDS       24284625//24209618//24981863 chr19:54377753-54377754(+) m6A 3'UTR       24284625//24209618//24981863 chr19:54378168-54378169(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr19:54378306-54378307(+) m6A 3'UTR       24209618 chr19:54378866-54378867(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr19:54378903-54378904(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr19:54379001-54379002(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr19:54379007-54379008(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr19:54379083-54379084(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr19:54379093-54379094(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr19:54379129-54379130(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr19:54379146-54379147(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr19:54379172-54379173(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr19:54379310-54379311(+) m6A 3'UTR       24284625//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	MYADM	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: MYADM

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).