Basic Information:

  VIRBase ID:  

HHID00005154

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          ZIC5:  NR_146224     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	ZIC5
miRBase Accession/Entrez ID	MIMAT0000458	85416
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZIC5	chr13:100615543-100615544(-) m6A 3'UTR       24981863 chr13:100615553-100615554(-) m6A 3'UTR       24981863 chr13:100615583-100615584(-) m6A 3'UTR       24981863 chr13:100616808-100616809(-) m6A 3'UTR       24981863 chr13:100616819-100616820(-) m6A 3'UTR       24981863 chr13:100617091-100617092(-) m6A 3'UTR       24284625//22608085 chr13:100617123-100617124(-) m6A 3'UTR       24284625//22608085 chr13:100617218-100617219(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr13:100617391-100617392(-) m6A 3'UTR       25456834//24981863//27773535//22608085 chr13:100617404-100617405(-) m6A 3'UTR       25456834//24981863//27773535//22608085 chr13:100617415-100617416(-) m6A 3'UTR       25456834//24981863//27773535//22608085 chr13:100617487-100617488(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr13:100617529-100617530(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr13:100617546-100617547(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085 chr13:100617563-100617564(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr13:100617581-100617582(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr13:100617658-100617659(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr13:100617683-100617684(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr13:100617695-100617696(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr13:100617811-100617812(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr13:100617845-100617846(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr13:100617870-100617871(-) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085 chr13:100618002-100618003(-) m6A CDS       24284625//27773535//22608085 chr13:100622629-100622630(-) m6A CDS       25456834 chr13:100623324-100623325(-) m6A CDS       25456834//24981863//27773536 chr13:100623342-100623343(-) m6A CDS       25456834//24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	ZIC5	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: ZIC5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).