Basic Information:

  VIRBase ID:  

HHID00005136

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          SPIRE2:  NM_032451     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	SPIRE2
miRBase Accession/Entrez ID	MIMAT0000458	84501
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Spir-2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SPIRE2	chr16:89934062(+) A-I      intronic chr16:89905661(+) A-I      intronic chr16:89905629(+) A-I      intronic chr16:89898079(+) A-I      intronic chr16:89898088(+) A-I      intronic chr16:89905625(+) A-I      intronic chr16:89904538(+) A-I      intronic chr16:89904520(+) A-I      intronic chr16:89902319(+) A-I      intronic chr16:89903309(+) A-I      intronic chr16:89904507(+) A-I      intronic chr16:89907547(+) A-I      intronic chr16:89907549(+) A-I      intronic chr16:89934255(+) A-I      intronic chr16:89905635(+) A-I      intronic chr16:89910812(+) A-I      intronic chr16:89931621(+) A-I      intronic chr16:89905628(+) A-I      intronic chr16:89904512(+) A-I      intronic chr16:89911108(+) A-I      intronic chr16:89904684(+) A-I      intronic chr16:89904508(+) A-I      intronic chr16:89902397(+) A-I      intronic chr16:89903138(+) A-I      intronic chr16:89902396(+) A-I      intronic chr16:89902407(+) A-I      intronic chr16:89904509(+) A-I      intronic chr16:89934179(+) A-I      intronic chr16:89906930(+) A-I      intronic chr16:89910819(+) A-I      intronic chr16:89902441(+) A-I      intronic chr16:89923395(+) A-I      intronic chr16:89902368(+) A-I      intronic chr16:89904477(+) A-I      intronic chr16:89904708(+) A-I      intronic chr16:89902511(+) A-I      intronic chr16:89928739(+) A-I      intronic chr16:89898012(+) A-I      intronic chr16:89911107(+) A-I      intronic chr16:89904854(+) A-I      intronic chr16:89935231(+) A-I      intronic chr16:89905494(+) A-I      intronic chr16:89933777(+) A-I      intronic chr16:89932265(+) A-I      intronic chr16:89903352(+) A-I      intronic chr16:89932770(+) A-I      intronic chr16:89903382(+) A-I      intronic chr16:89902418(+) A-I      intronic chr16:89932434(+) A-I      intronic chr16:89902328(+) A-I      intronic chr16:89932326(+) A-I      intronic chr16:89907307(+) A-I      intronic chr16:89903282(+) A-I      intronic chr16:89937495(+) A-I      3'UTR chr16:89937351(+) A-I      3'UTR chr16:89934073(+) A-I      intronic chr16:89932116(+) A-I      intronic chr16:89934183(+) A-I      intronic chr16:89907319(+) A-I      intronic chr16:89898087(+) A-I      intronic chr16:89904547(+) A-I      intronic chr16:89932423(+) A-I      intronic chr16:89910716(+) A-I      intronic chr16:89903272(+) A-I      intronic chr16:89932762(+) A-I      intronic chr16:89910773(+) A-I      intronic chr16:89932913(+) A-I      intronic chr16:89902333(+) A-I      intronic chr16:89904439(+) A-I      intronic chr16:89932472(+) A-I      intronic chr16:89902533(+) A-I      intronic chr16:89910194(+) A-I      intronic chr16:89905630(+) A-I      intronic chr16:89897886(+) A-I      intronic chr16:89934276(+) A-I      intronic chr16:89933291(+) A-I      intronic chr16:89911053(+) A-I      intronic chr16:89932477(+) A-I      intronic chr16:89910490(+) A-I      intronic chr16:89933156(+) A-I      intronic chr16:89928717(+) A-I      intronic chr16:89932114(+) A-I      intronic chr16:89923403(+) A-I      intronic chr16:89932321(+) A-I      intronic chr16:89917338(+) A-I      intronic chr16:89904537(+) A-I      intronic chr16:89935178(+) A-I      intronic chr16:89904627(+) A-I      intronic chr16:89907521(+) A-I      intronic chr16:89934267(+) A-I      intronic chr16:89910613(+) A-I      intronic chr16:89931519(+) A-I      intronic chr16:89935010(+) A-I      intronic chr16:89910986(+) A-I      intronic chr16:89932806(+) A-I      intronic chr16:89923283(+) A-I      intronic chr16:89923199(+) A-I      intronic chr16:89903378(+) A-I      intronic chr16:89903324(+) A-I      intronic chr16:89907458(+) A-I      intronic chr16:89931476(+) A-I      intronic chr16:89907321(+) A-I      intronic chr16:89910677(+) A-I      intronic chr16:89923423(+) A-I      intronic chr16:89934275(+) A-I      intronic chr16:89932544(+) A-I      intronic chr16:89902495(+) A-I      intronic chr16:89931696(+) A-I      intronic chr16:89910878(+) A-I      intronic chr16:89932775(+) A-I      intronic chr16:89932296(+) A-I      intronic chr16:89910767(+) A-I      intronic chr16:89905631(+) A-I      intronic chr16:89932255(+) A-I      intronic chr16:89903202(+) A-I      intronic chr16:89932482(+) A-I      intronic chr16:89934122(+) A-I      intronic chr16:89902321(+) A-I      intronic chr16:89932887(+) A-I      intronic chr16:89931544(+) A-I      intronic chr16:89933483(+) A-I      intronic chr16:89910188(+) A-I      intronic chr16:89902327(+) A-I      intronic chr16:89911265(+) A-I      intronic chr16:89902484(+) A-I      intronic chr16:89910329(+) A-I      intronic chr16:89934132(+) A-I      intronic chr16:89907465(+) A-I      intronic chr16:89935142(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SPIRE2	chr16:89907574(+) A-I intron -    21960545 chr16:89907579(+) A-I intron -    21960545 chr16:89907598(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPIRE2	chr16:89884683-89884684(+) m6A exon       24284625//24981863//22608085 chr16:89884725-89884726(+) m6A exon       24284625//24981863//22608085 chr16:89884747-89884748(+) m6A exon       24284625//24981863//27773535//22608085 chr16:89884807-89884808(+) m6A exon       24284625//24981863//27773535//22608085 chr16:89884831-89884832(+) m6A exon       24284625//24981863//27773535//22608085 chr16:89884876-89884877(+) m6A exon       24284625//27773535//22608085 chr16:89884897-89884898(+) m6A exon       24284625//27773535//22608085 chr16:89888856-89888857(+) m6A exon//intron       24284625 chr16:89895148-89895149(+) m6A CDS//intron       24209618 chr16:89896462-89896463(+) Am intron       - chr16:89902732-89902733(+) m6A 3'UTR//intron       24284625 chr16:89902738-89902739(+) m6A 3'UTR//intron       24284625 chr16:89902775-89902776(+) m6A 3'UTR//intron       24284625 chr16:89912081-89912082(+) m6A 3'UTR//intron       24981863 chr16:89912119-89912120(+) m6A 3'UTR//intron       24981863 chr16:89912170-89912171(+) m6A 3'UTR//intron       24981863 chr16:89912176-89912177(+) m6A 3'UTR//intron       24981863 chr16:89913404-89913405(+) m6A 3'UTR//intron       24981863 chr16:89913415-89913416(+) m6A 3'UTR//intron       24981863 chr16:89916711-89916712(+) m6A 3'UTR//CDS//exon       24284625 chr16:89916751-89916752(+) m6A 3'UTR//CDS//exon       24284625 chr16:89916765-89916766(+) Gm 3'UTR//CDS//exon       - chr16:89916782-89916783(+) m6A 3'UTR//CDS//exon       24284625 chr16:89916838-89916839(+) m6A 3'UTR//CDS//exon       24284625 chr16:89920751-89920752(+) m6A 3'UTR//CDS//exon       24284625 chr16:89920769-89920770(+) m6A 3'UTR//CDS//exon       24284625 chr16:89920948-89920949(+) m1A 3'UTR//CDS//exon       26863196//26863410 chr16:89921021-89921022(+) m6A 3'UTR//CDS//exon       24284625 chr16:89921036-89921037(+) m6A 3'UTR//CDS//exon       24284625 chr16:89922017-89922018(+) m6A 3'UTR//CDS//exon       - chr16:89922037-89922038(+) m1A 3'UTR//CDS//exon       26863196 chr16:89925756-89925757(+) m6A CDS//exon       24284625 chr16:89927156-89927157(+) m6A CDS//exon       24284625 chr16:89927190-89927191(+) m6A CDS//exon       24284625 chr16:89928431-89928432(+) m6A exon//intron       24284625 chr16:89929596-89929597(+) m6A exon//intron       - chr16:89929605-89929606(+) m6A exon//intron       - chr16:89929718-89929719(+) m6A exon//intron       24284625//22608085 chr16:89929741-89929742(+) m6A exon//intron       22608085 chr16:89929757-89929758(+) m6A exon//intron       22608085 chr16:89929857-89929858(+) m6A exon//intron       24284625 chr16:89929983-89929984(+) m6A CDS//exon       24284625 chr16:89936000-89936001(+) m6A CDS//exon//intron       - chr16:89936058-89936059(+) m6A CDS//exon//intron       - chr16:89936080-89936081(+) m6A CDS//exon//intron       - chr16:89936632-89936633(+) m6A CDS//exon       24284625//24981863 chr16:89936662-89936663(+) m6A CDS//exon       24284625//24981863 chr16:89937559-89937560(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	SPIRE2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: SPIRE2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).