Detail Information

Basic Information:


  VIRBase ID:  

HHID00005041

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           BCL11B:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p BCL11B
miRBase
Accession/Entrez ID		 MIMAT0000458 64919
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ATL1//ATL1-alpha//ATL1-beta//ATL1-delta//ATL1-gamma//CTIP-2//CTIP2//hRIT1-alpha//IDDFSTA//IMD49//RIT1//ZNF856B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BCL11B
chr14:99651652(-) A-I      intronic
chr14:99716282(-) A-I      intronic
chr14:99652749(-) A-I      intronic
chr14:99716301(-) A-I      intronic
chr14:99716208(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BCL11B
chr14:99638569-99638570(-) m6A 3'UTR       26404942//27371828
chr14:99638617-99638618(-) m6A 3'UTR       26404942//27371828//22608085
chr14:99638660-99638661(-) m6A 3'UTR       26404942//27371828//22608085
chr14:99638677-99638678(-) m6A 3'UTR       26404942//27371828//22608085
chr14:99638699-99638700(-) m6A 3'UTR       26404942//27371828//22608085
chr14:99638776-99638777(-) m6A 3'UTR       24981863//26404942
chr14:99638800-99638801(-) m6A 3'UTR       24981863//26404942
chr14:99638818-99638819(-) m6A 3'UTR       24981863//26404942
chr14:99638840-99638841(-) m6A 3'UTR       24981863//26404942
chr14:99638851-99638852(-) m6A 3'UTR       24981863//26404942
chr14:99638879-99638880(-) m6A 3'UTR       24981863//26404942
chr14:99640320-99640321(-) m6A 3'UTR       25456834//24981863//27371828
chr14:99640449-99640450(-) m6A 3'UTR       25456834//24981863//27371828
chr14:99640559-99640560(-) m6A CDS       25456834//24981863//26404942//27371828
chr14:99640752-99640753(-) m6A CDS       25456834//24981863//27371828
chr14:99640899-99640900(-) m6A CDS       25456834//27371828//27773536
chr14:99641001-99641002(-) m6A CDS       24209618//25456834//24981863//27371828//27773536//22608085
chr14:99641094-99641095(-) m6A CDS       25456834//24981863//27371828//27773536
chr14:99641496-99641497(-) m6A CDS       25456834//27371828//27773536
chr14:99641869-99641870(-) m6A CDS       27371828
chr14:99641994-99641995(-) m6A CDS       27371828
chr14:99642087-99642088(-) m6A CDS       24981863//27371828
chr14:99642117-99642118(-) m6A CDS       24981863//27371828
chr14:99642195-99642196(-) m6A CDS       27371828
chr14:99642270-99642271(-) m6A CDS       27371828
chr14:99723815-99723816(-) m6A CDS//intron       27371828//27773536
chr14:99723947-99723948(-) m6A CDS//intron       25456834//27371828//27773536
chr14:99723953-99723954(-) m6A CDS//intron       25456834//27371828//27773536
chr14:99724028-99724029(-) m6A CDS//intron       24981863//27371828
chr14:99724043-99724044(-) m6A CDS//intron       24981863//27371828
chr14:99737540-99737541(-) m6A CDS       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
BCL11B
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: BCL11B

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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