Basic Information:

  VIRBase ID:  

HHID00005020

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          DMRTA2:  NM_032110     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	DMRTA2
miRBase Accession/Entrez ID	MIMAT0000458	63950
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DMRTA2	chr1:50883339-50883340(-) m6A 3'UTR       24981863 chr1:50883374-50883375(-) m6A 3'UTR       24981863 chr1:50883400-50883401(-) m6A 3'UTR       24981863 chr1:50883486-50883487(-) m6A 3'UTR       24981863 chr1:50883535-50883536(-) m6A 3'UTR       24981863 chr1:50883555-50883556(-) m6A 3'UTR       24981863 chr1:50883571-50883572(-) m6A 3'UTR       24981863 chr1:50883580-50883581(-) m6A 3'UTR       24981863 chr1:50884147-50884148(-) m6A 3'UTR       27773536 chr1:50884297-50884298(-) m6A 3'UTR       27773536 chr1:50884303-50884304(-) m6A 3'UTR       27773536 chr1:50884460-50884461(-) m6A CDS       27773536 chr1:50884714-50884715(-) m6A CDS       27773536 chr1:50884910-50884911(-) m6A CDS       27773536 chr1:50885138-50885139(-) m6A CDS       27773536 chr1:50885297-50885298(-) m6A CDS       27773536 chr1:50886682-50886683(-) m6A CDS       27773536 chr1:50886707-50886708(-) m6A CDS       27773536 chr1:50886930-50886931(-) m6A CDS       24981863//27773536 chr1:50887009-50887010(-) m6A CDS       27773536 chr1:50888923-50888924(-) m6A 5'UTR       24981863//27773536 chr1:50888957-50888958(-) m6A 5'UTR       27773536 chr1:50889044-50889045(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	DMRTA2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: DMRTA2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).