Basic Information:

  VIRBase ID:  

HHID00005010

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PLEKHA1:  NM_001377247     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PLEKHA1
miRBase Accession/Entrez ID	MIMAT0000458	59338
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TAPP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLEKHA1	chr10:124190740(+) A-I      3'UTR chr10:124190738(+) A-I      3'UTR chr10:124190737(+) A-I      3'UTR chr10:124190766(+) A-I      3'UTR chr10:124190776(+) A-I      3'UTR chr10:124190770(+) A-I      3'UTR chr10:124166494(+) A-I      intronic chr10:124177085(+) A-I      intronic chr10:124144365(+) A-I      intronic chr10:124159300(+) A-I      intronic chr10:124159286(+) A-I      intronic chr10:124144938(+) A-I      intronic chr10:124144374(+) A-I      intronic chr10:124142905(+) A-I      intronic chr10:124144999(+) A-I      intronic chr10:124144937(+) A-I      intronic chr10:124144311(+) A-I      intronic chr10:124179534(+) A-I      ncRNA chr10:124185117(+) A-I      ncRNA chr10:124144075(+) A-I      intronic chr10:124144951(+) A-I      intronic chr10:124145015(+) A-I      intronic chr10:124144392(+) A-I      intronic chr10:124144305(+) A-I      intronic chr10:124144998(+) A-I      intronic chr10:124142872(+) A-I      intronic chr10:124144259(+) A-I      intronic chr10:124142899(+) A-I      intronic chr10:124144973(+) A-I      intronic chr10:124138141(+) A-I      intronic chr10:124144978(+) A-I      intronic chr10:124144352(+) A-I      intronic chr10:124144934(+) A-I      intronic chr10:124144207(+) A-I      intronic chr10:124142975(+) A-I      intronic chr10:124144384(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLEKHA1	chr10:124175460-124175461(+) m6A CDS//exon       27773535 chr10:124189168-124189169(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr10:124189302-124189303(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189316-124189317(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189333-124189334(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189354-124189355(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189369-124189370(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189416-124189417(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189596-124189597(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	PLEKHA1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PLEKHA1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).