Basic Information:

  VIRBase ID:  

HHID00005002

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          CYP4F11:  NM_001128932     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	CYP4F11
miRBase Accession/Entrez ID	MIMAT0000458	57834
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CYPIVF11

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CYP4F11	chr19:16024127-16024128(-) m6A 3'UTR       24981863 chr19:16024147-16024148(-) m6A 3'UTR       24981863 chr19:16024197-16024198(-) m6A 3'UTR       24981863 chr19:16024215-16024216(-) m6A 3'UTR       24981863 chr19:16024221-16024222(-) m6A 3'UTR       24981863 chr19:16024251-16024252(-) m6A 3'UTR       24981863 chr19:16024305-16024306(-) m6A 3'UTR       24981863 chr19:16024377-16024378(-) m6A 3'UTR       24981863 chr19:16024384-16024385(-) m6A 3'UTR       24981863 chr19:16024440-16024441(-) m6A 3'UTR       24981863 chr19:16024496-16024497(-) m6A 3'UTR       24981863 chr19:16024501-16024502(-) m6A 3'UTR       24981863 chr19:16024551-16024552(-) m6A 3'UTR//CDS       24981863 chr19:16024583-16024584(-) m6A 3'UTR//CDS       24981863 chr19:16024613-16024614(-) m6A 3'UTR//CDS       24981863 chr19:16024625-16024626(-) m6A 3'UTR//CDS       24981863 chr19:16045106-16045107(-) m6A CDS       - chr19:16045559-16045560(-) m6A 5'UTR//intron       24981863 chr19:16045631-16045632(-) m6A 5'UTR//intron       24981863 chr19:16045666-16045667(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	CYP4F11	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: CYP4F11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).