Detail Information

Basic Information:


  VIRBase ID:  

HHID00004987

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           PCDH10:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p PCDH10
miRBase
Accession/Entrez ID		 MIMAT0000458 57575
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - OL-PCDH//PCDH19

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PCDH10
chr4:134104370(+) A-I      intronic
chr4:134104368(+) A-I      intronic
chr4:134104403(+) A-I      intronic
chr4:134104397(+) A-I      intronic
chr4:134104422(+) A-I      intronic
chr4:134104391(+) A-I      intronic
chr4:134112566(+) A-I      3'UTR
chr4:134092054(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PCDH10
chr4:134070502-134070503(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070519-134070520(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070551-134070552(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070565-134070566(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070611-134070612(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070620-134070621(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070626-134070627(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070636-134070637(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070682-134070683(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070777-134070778(+) Y 5'UTR       26075521
chr4:134070922-134070923(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070933-134070934(+) m6A 5'UTR       25456834//24981863//22608085
chr4:134070982-134070983(+) m6A 5'UTR       24981863//22608085
chr4:134071161-134071162(+) m6A 5'UTR       24981863//22608085
chr4:134071381-134071382(+) m6A CDS       25456834//24981863//22608085
chr4:134071425-134071426(+) m6A CDS       25456834//24981863//22608085
chr4:134071435-134071436(+) m6A CDS       25456834//24981863//22608085
chr4:134071475-134071476(+) m6A CDS       25456834//24981863//22608085
chr4:134071488-134071489(+) m6A CDS       25456834//24981863//22608085
chr4:134071502-134071503(+) m6A CDS       25456834//24981863//22608085
chr4:134071533-134071534(+) m6A CDS       25456834//24981863//22608085
chr4:134071540-134071541(+) m6A CDS       25456834//24981863//22608085
chr4:134071552-134071553(+) m6A CDS       25456834//24981863//22608085
chr4:134071596-134071597(+) m6A CDS       25456834//24981863//22608085
chr4:134071635-134071636(+) m6A CDS       25456834//24981863//22608085
chr4:134071671-134071672(+) m6A CDS       25456834//24981863//22608085
chr4:134071811-134071812(+) m6A CDS       25456834//24981863//22608085
chr4:134071863-134071864(+) m6A CDS       25456834//24981863//22608085
chr4:134072019-134072020(+) m6A CDS       25456834//24981863//22608085
chr4:134072079-134072080(+) m6A CDS       25456834//24981863//22608085
chr4:134072200-134072201(+) m6A CDS       25456834//24981863//22608085
chr4:134072221-134072222(+) m6A CDS       25456834//24981863//22608085
chr4:134072244-134072245(+) m6A CDS       25456834//24981863//22608085
chr4:134072289-134072290(+) m6A CDS       25456834//24981863//22608085
chr4:134072559-134072560(+) m6A CDS       25456834//24981863//22608085
chr4:134072574-134072575(+) m6A CDS       25456834//24981863//22608085
chr4:134072604-134072605(+) m6A CDS       25456834//24981863//22608085
chr4:134072718-134072719(+) m6A CDS       25456834//24981863//22608085
chr4:134072907-134072908(+) m6A CDS       25456834//24981863//22608085
chr4:134073044-134073045(+) m6A CDS       25456834//24981863//22608085
chr4:134073174-134073175(+) m6A CDS       25456834//24981863//22608085
chr4:134073189-134073190(+) m6A CDS       25456834//24981863//22608085
chr4:134073637-134073638(+) m6A CDS       22608085
chr4:134073651-134073652(+) m6A CDS       24981863//22608085
chr4:134073788-134073789(+) m6A CDS       24981863//22608085
chr4:134073834-134073835(+) m6A CDS       24981863//22608085
chr4:134073945-134073946(+) m6A CDS//intron       -
chr4:134075466-134075467(+) m6A CDS       24981863//22608085
chr4:134075502-134075503(+) m6A CDS       24981863//22608085
chr4:134084182-134084183(+) Cm CDS//exon       -
chr4:134084269-134084270(+) m6A CDS//exon       25456834
chr4:134084281-134084282(+) m6A CDS//exon       25456834
chr4:134084298-134084299(+) m6A CDS//exon       25456834
chr4:134084393-134084394(+) m6A CDS//exon       25456834//24981863
chr4:134084423-134084424(+) m6A CDS//exon       24981863//22608085
chr4:134111328-134111329(+) m6A 3'UTR//intron       24981863//22608085
chr4:134111467-134111468(+) m6A 3'UTR//intron       24981863//22575960//22608085
chr4:134111514-134111515(+) m6A 3'UTR//intron       24981863//22575960//22608085
chr4:134111523-134111524(+) m6A 3'UTR//intron       24981863//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
PCDH10
Cytosol HeLa-S3 cells     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: PCDH10

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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