Basic Information:

  VIRBase ID:  

HHID00004975

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          GRAMD1B:  NM_001286563     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	GRAMD1B
miRBase Accession/Entrez ID	MIMAT0000458	57476
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LINC01059

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	GRAMD1B	chr11: 123330093     chr11: 123330143     chr11: 123330112

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GRAMD1B	chr11:123470009(+) A-I      intronic chr11:123470003(+) A-I      intronic chr11:123470037(+) A-I      intronic chr11:123470061(+) A-I      intronic chr11:123469999(+) A-I      intronic chr11:123470084(+) A-I      intronic chr11:123470066(+) A-I      intronic chr11:123470077(+) A-I      intronic chr11:123470101(+) A-I      intronic chr11:123470112(+) A-I      intronic chr11:123492916(+) A-I      intronic chr11:123410108(+) A-I      intronic chr11:123460281(+) A-I      intronic chr11:123403900(+) A-I      intronic chr11:123409786(+) A-I      intronic chr11:123482893(+) A-I      intronic chr11:123487915(+) A-I      intronic chr11:123437219(+) A-I      intronic chr11:123488021(+) A-I      intronic chr11:123492846(+) A-I      intronic chr11:123428785(+) A-I      intronic chr11:123409473(+) A-I      intronic chr11:123486909(+) A-I      intronic chr11:123435937(+) A-I      intronic chr11:123463945(+) A-I      intronic chr11:123405426(+) A-I      intronic chr11:123423122(+) A-I      intronic chr11:123407003(+) A-I      intronic chr11:123409790(+) A-I      intronic chr11:123410226(+) A-I      intronic chr11:123420111(+) A-I      intronic chr11:123426174(+) A-I      intronic chr11:123402500(+) A-I      intronic chr11:123486951(+) A-I      intronic chr11:123402544(+) A-I      intronic chr11:123402665(+) A-I      intronic chr11:123402673(+) A-I      intronic chr11:123402692(+) A-I      intronic chr11:123410843(+) A-I      intronic chr11:123402697(+) A-I      intronic chr11:123403845(+) A-I      intronic chr11:123403931(+) A-I      intronic chr11:123403940(+) A-I      intronic chr11:123403941(+) A-I      intronic chr11:123405462(+) A-I      intronic chr11:123405475(+) A-I      intronic chr11:123409408(+) A-I      intronic chr11:123409589(+) A-I      intronic chr11:123409834(+) A-I      intronic chr11:123410109(+) A-I      intronic chr11:123410147(+) A-I      intronic chr11:123410152(+) A-I      intronic chr11:123410873(+) A-I      intronic chr11:123410908(+) A-I      intronic chr11:123411023(+) A-I      intronic chr11:123419347(+) A-I      intronic chr11:123419355(+) A-I      intronic chr11:123419598(+) A-I      intronic chr11:123419984(+) A-I      intronic chr11:123420129(+) A-I      intronic chr11:123420147(+) A-I      intronic chr11:123423112(+) A-I      intronic chr11:123426136(+) A-I      intronic chr11:123426137(+) A-I      intronic chr11:123426157(+) A-I      intronic chr11:123435870(+) A-I      intronic chr11:123435882(+) A-I      intronic chr11:123435930(+) A-I      intronic chr11:123436021(+) A-I      intronic chr11:123491088(+) A-I      intronic chr11:123491093(+) A-I      intronic chr11:123487943(+) A-I      intronic chr11:123435811(+) A-I      intronic chr11:123482102(+) A-I      intronic chr11:123434244(+) A-I      intronic chr11:123428872(+) A-I      intronic chr11:123423163(+) A-I      intronic chr11:123486776(+) A-I      intronic chr11:123492829(+) A-I      intronic chr11:123435773(+) A-I      intronic chr11:123407088(+) A-I      intronic chr11:123420075(+) A-I      intronic chr11:123410235(+) A-I      intronic chr11:123491006(+) A-I      intronic chr11:123407068(+) A-I      intronic chr11:123419445(+) A-I      intronic chr11:123490949(+) A-I      intronic chr11:123403859(+) A-I      intronic chr11:123410128(+) A-I      intronic chr11:123486777(+) A-I      intronic chr11:123493007(+) A-I      intronic chr11:123490950(+) A-I      intronic chr11:123435860(+) A-I      intronic chr11:123490924(+) A-I      intronic chr11:123410802(+) A-I      intronic chr11:123491132(+) A-I      intronic chr11:123411068(+) A-I      intronic chr11:123402679(+) A-I      intronic chr11:123409599(+) A-I      intronic chr11:123491005(+) A-I      intronic chr11:123425397(+) A-I      intronic chr11:123486932(+) A-I      intronic chr11:123482845(+) A-I      intronic chr11:123491084(+) A-I      intronic chr11:123420156(+) A-I      intronic chr11:123426519(+) A-I      intronic chr11:123492914(+) A-I      intronic chr11:123426568(+) A-I      intronic chr11:123437363(+) A-I      intronic chr11:123437353(+) A-I      intronic chr11:123426571(+) A-I      intronic chr11:123409376(+) A-I      intronic chr11:123482021(+) A-I      intronic chr11:123406976(+) A-I      intronic chr11:123434320(+) A-I      intronic chr11:123487992(+) A-I      intronic chr11:123490926(+) A-I      intronic chr11:123407008(+) A-I      intronic chr11:123491017(+) A-I      intronic chr11:123410292(+) A-I      intronic chr11:123486217(+) A-I      intronic chr11:123437220(+) A-I      intronic chr11:123402683(+) A-I      intronic chr11:123492862(+) A-I      intronic chr11:123492953(+) A-I      intronic chr11:123409529(+) A-I      intronic chr11:123490981(+) A-I      intronic chr11:123403901(+) A-I      intronic chr11:123419998(+) A-I      intronic chr11:123492951(+) A-I      intronic chr11:123411008(+) A-I      intronic chr11:123407002(+) A-I      intronic chr11:123491067(+) A-I      intronic chr11:123488009(+) A-I      intronic chr11:123492903(+) A-I      intronic chr11:123425338(+) A-I      intronic chr11:123425164(+) A-I      intronic chr11:123409445(+) A-I      intronic chr11:123407049(+) A-I      intronic chr11:123425303(+) A-I      intronic chr11:123493005(+) A-I      intronic chr11:123409467(+) A-I      intronic chr11:123420020(+) A-I      intronic chr11:123467952(+) A-I      intronic chr11:123406962(+) A-I      intronic chr11:123492993(+) A-I      intronic chr11:123492833(+) A-I      intronic chr11:123409541(+) A-I      intronic chr11:123491062(+) A-I      intronic chr11:123460255(+) A-I      intronic chr11:123426498(+) A-I      intronic chr11:123420087(+) A-I      intronic chr11:123402684(+) A-I      intronic chr11:123425297(+) A-I      intronic chr11:123419458(+) A-I      intronic chr11:123403734(+) A-I      intronic chr11:123492841(+) A-I      intronic chr11:123405361(+) A-I      intronic chr11:123487950(+) A-I      intronic chr11:123406861(+) A-I      intronic chr11:123410110(+) A-I      intronic chr11:123425163(+) A-I      intronic chr11:123409532(+) A-I      intronic chr11:123405299(+) A-I      intronic chr11:123491200(+) A-I      intronic chr11:123409446(+) A-I      intronic chr11:123403899(+) A-I      intronic chr11:123426196(+) A-I      intronic chr11:123488171(+) A-I      intronic chr11:123435880(+) A-I      intronic chr11:123402625(+) A-I      intronic chr11:123402634(+) A-I      intronic chr11:123435967(+) A-I      intronic chr11:123491083(+) A-I      intronic chr11:123426559(+) A-I      intronic chr11:123492966(+) A-I      intronic chr11:123490982(+) A-I      intronic chr11:123488031(+) A-I      intronic chr11:123409360(+) A-I      intronic chr11:123486272(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GRAMD1B	chr11:123405361(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GRAMD1B	chr11:123325339-123325340(+) m6A exon       24981863 chr11:123325496-123325497(+) m6A 5'UTR//exon       24981863 chr11:123325531-123325532(+) m6A 5'UTR//exon       24981863 chr11:123430978-123430979(+) m6A 5'UTR//exon//intron       - chr11:123464823-123464824(+) m6A CDS//exon       - chr11:123474212-123474213(+) m6A CDS//exon       - chr11:123476096-123476097(+) m6A CDS//exon       24981863//26404942 chr11:123477428-123477429(+) m6A CDS//exon       - chr11:123477443-123477444(+) m6A CDS//exon       - chr11:123477461-123477462(+) m6A CDS//exon       - chr11:123484211-123484212(+) m6A CDS//exon       24284625 chr11:123484239-123484240(+) m6A CDS//exon       24284625 chr11:123484355-123484356(+) m6A CDS//exon       24284625 chr11:123485482-123485483(+) m6A CDS//exon       - chr11:123493220-123493221(+) m6A CDS//exon       24981863 chr11:123493313-123493314(+) m6A 3'UTR//exon       24981863 chr11:123493354-123493355(+) m6A 3'UTR//exon       24981863 chr11:123493531-123493532(+) m6A 3'UTR       - chr11:123493868-123493869(+) Cm 3'UTR       - chr11:123494332-123494333(+) m6A 3'UTR       - chr11:123494389-123494390(+) m6A 3'UTR       - chr11:123494422-123494423(+) m6A 3'UTR       - chr11:123497776-123497777(+) m6A 3'UTR       24981863 chr11:123497864-123497865(+) m6A 3'UTR       24981863 chr11:123497909-123497910(+) m6A 3'UTR       24981863 chr11:123498016-123498017(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	GRAMD1B	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: GRAMD1B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).